Effect of Citalopram in Combination  with Omega-3 on Depression in Post- menopausal Women: A Triple Blind  Randomized Controlled Trial

Masoumi, Seyedeh Zahra; Kazemi, Farideh; Tavakolian, Samira; Rahimi, Alireza; Oshvandi, Khodayar; Soltanian, Ali Reza

doi:10.7860/jcdr/2016/19487.8597

Cited by 10 publications

(14 citation statements)

References 20 publications

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“…Finally, we found only one RCT study exploring the combined effect of n-3 LCPUFAs and SSRI (citalopram) for the treatment of 60 postmenopausal depressed women (aged 45–65 years old) [ 74 ]. This is a triple-blind randomized controlled trial where the control group received 20 mg citalopram plus a placebo, whereas the intervention group received 20 mg citalopram and 1 g of n-3 LCPUFAs for a week.…”

Section: Resultsmentioning

confidence: 99%

N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms

Ciappolino

Mazzocchi

Enrico

et al. 2018

IJMS

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Depression is one of the most important health problems worldwide. Women are 2.5 times more likely to experience major depression than men. Evidence suggests that some women might experience an increased risk for developing depression during “windows of vulnerability”, i.e., when exposed to intense hormone fluctuations, such as the menopause transition. Indeed, this period is associated with different symptoms, including vasomotor, depressive, and cognitive symptoms, which have all been shown to worsen as women approach menopause. Even though hormonal therapy represents the most effective treatment, side effects have been reported by several studies. Therefore, an increased number of women might prefer the use of alternative medicine for treating menopausal symptoms. N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are included among these alternative treatments. We here provide a review of studies investigating the effects of n-3 LCPUFAs on hot flashes and depressive and cognitive disorders in menopausal women. The reported results are scattered and heterogeneous. In conclusion, a beneficial role of n-3 LCPUFAs in hot flashes, and depressive and cognitive symptoms related to menopausal transition is still far from conclusive.

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Section: Resultsmentioning

confidence: 99%

N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms

Ciappolino

Mazzocchi

Enrico

et al. 2018

IJMS

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“…The same authors [51] reported that a diet with high n-6:n-3 PUFA ratios is associated in the elderly with an elevated risk of depression and inflammatory diseases. Only trends regarding to depression could be seen in 60 females aged 45-65 in a triple blind design study of PUFA supplementation in combination with citalopram [52]. A placebo-controlled study on shift workers (n = 136) demonstrated reduced BDI scores in all groups, including placebo [53,54].…”

Section: Other Supplementsmentioning

confidence: 99%

“…As a natural source of PUFA, fish oil, combined with a Mediterranean diet, also had a positive effect on depression [60]. Administration of supplements like DHA, PUFA, and fish oil showed a positive effect therapeutical approach, inflammatory factors, pathophysiology, and pathoetiology of depression [49][50][51][52][53][54][55][56][57][58][59][60].…”

Section: Other Supplementsmentioning

confidence: 99%

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review

Hoffmann

Emons

Brunnhuber³

et al. 2019

Pharmacopsychiatry

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Introduction Dietary supplements are very widely used in the general population and there is a growing market for them, which is against the recommendations of the German Society for Nutrition. There is some evidence that dietary supplements are useful additions in the treatment of psychiatric disorders. This review is an overview of available practical knowledge regarding the use of supplements in psychiatric treatment. In particular, the review focused on the diagnosis of depression and anxiety in terms of supplement treatment. Methods This is a narrative review of the evidence regarding supplements for treating anxiety and depression. We searched PubMed to 2018. Two reviewers screened the citations and abstracted the data. Phytopharmaceutical attends and animal-based data were excluded. Results There are strong indications regarding the impact of supplements on the selected psychiatric disorders, but at this time, there only a few randomized clinical studies available, so evidence for these findings is quite low. However, it must be noted that there are strong hints for a relationship between vitamin D level and depression. Furthermore, various supplements have got potentially an influence on the characteristics of depression. Discussion This review summarizes the current knowledge about supplements when used for some psychiatric conditions, but the data does not provide compelling evidence in any direction. There are only indications that there is an influence of supplements on psychiatric diseases. In support of this, there is further need for high-quality studies in this field. Reviews on other diagnoses, such as schizophrenia and dementia, will be part of further work.

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“…In cognitive behavioral approach, attention is paid to sex education that Iranian couples need and do not obtain by a reliable method. [27,28] According to the mentioned issues, it is determined that, in the culture of Iranian society, paying attention to cognitive factors is highly important to resolve sexual problems, dysfunction, and dissatisfaction and neglecting them leads to a decrease in therapeutic purposes. Cognitive-behavioral family therapy training causes the couples to be equipped with skills necessary for marital life and generalizes these teachings to other levels of marital and social levels of life.…”

Section: Discussionmentioning

confidence: 99%

The effect of cognitive behavioral consultation on marital quality among women

Garousian¹,

Khani²,

Shayan³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Marital quality reflects the individual's total evaluation of marital relationship. The present study was carried out to examine the effect of cognitive behavioral consultation on marital quality among women. Aims and Objectives: The present study was a randomized clinical two-group trial which was carried out using a pre-test and post-test design on 198 qualified women who had referred to the selected healthcare centers in Hamadan in 2016. Materials and Methods: The intervention participants received four 2-h sessions of cognitive behavioral consultation. Demographic information questionnaire and marital quality scale were completed by the two groups before and after the intervention. To analyze the collected data, independent samples t-test, covariance analysis, or change analysis were employed using SPSS 21.0 software. Results: The mean age in the control group and the intervention group was 23.58 ± 7.54 and 35.04 ± 7.91 years, respectively. Covariance analysis was utilized to examine the marital quality scores. In this analysis, after the variables of age, marital quality score of agreement and satisfaction before the intervention and income status were modified, the total marital quality score experienced a significant change in all dimensions (P < 0.05), and the mean scores increased remarkably. Moreover, according to the cutoff point of the dimensions, the scores of all dimensions increased remarkably and the proportion of individuals with high marital quality before and after the intervention changed significantly (P < 0.05). Conclusion: Due to the role of sexual relations in stabilizing marriage, cognitive behavioral consultation was effective in improving marital quality, especially after agreement, and can be used in healthcare centers to improve the relationship between couples and reduce divorce statistics.

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Effect of Citalopram in Combination with Omega-3 on Depression in Post- menopausal Women: A Triple Blind Randomized Controlled Trial

Abstract: Using omega-3, can reduce the severity of depression in post-menopausal women.

Cited by 10 publications

References 20 publications

N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms

N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review

The effect of cognitive behavioral consultation on marital quality among women

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