Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials

Jamali, Navid; Jalali, Mohammad; Saffari-Chaleshtori, Javad; Samare-Najaf, Mohammad; Samareh, Ali

doi:10.1016/j.dsx.2020.01.009

Cited by 25 publications

(28 citation statements)

References 34 publications

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“…Inconsistent with our study, a systematic review & clinical trials meta-analysis for type 2 diabetes patients no significant effect of cinnamon supplementation on the B.M.I. 16 . Also another systematic review of clinical trials & meta-analysis Cinnamon supplementation cannot improve B.M.I.…”

Section: Effects On Bmisupporting

confidence: 83%

“…Another study of Randomized controlled trials found that adding cinnamon, magnesium, and chromium supplements to honey of kanuka type was accompanied by weight reduction 15 . Though cinnamon supplementation caused alterations in the weight, the result changes were statistically insignificant of that systematic review and meta-analysis of clinical trials stud 16 . Another systematic review and meta-analysis of clinical trials found that cinnamon intake had no beneficial changes on anthropometric parameters 17 .…”

Section: Effect On Weightmentioning

confidence: 87%

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Effect of cinnamon on blood sugar and anthropometric measurement in type two diabetes patients

Sadiq¹,

Abid²,

Jasim³

et al. 2021

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There is some emerging evidence that suggests certain supplements help lower blood sugar levels. One of these is cinnamon, which exhibits characteristics that mimic insulin, such as the activity of biologically active substances to activate insulin receptor kinase, increasing glucose uptake, autophosphorylation of the insulin receptor, and glycogen synthase activity. To assess the effect of the cinnamon substance on lowering fasting blood sugar, modifying body weight, body mass index (B.M.I.), and waist circumference in type two diabetics. A randomized controlled intervention clinical trial. The study was conducted on 60 patients with type II diabetes mellitus; the study followed both gender patients for four weeks. The contributors were allocated randomly into a group that receives 2 g/d cinnamon substance (intervention group), and a group without cinnamon substance is given (control group). Fasting plasma glucose (F.P.G.) and anthropometrics measurement at the beginning (beforehand cinnamon supplementation and 4week at the end of the study duration). After 4 weeks of cinnamon taken, serum F.P.G. levels significantly improved (P≤0.0001). Anthropometric measurements (weight, height, B.M.I.) were reduced significantly (change mean ≤ P=0.001) for all. The Present study disclosed that supplementation of 2 gm cinnamon improves F.P.G. and has a good role in anthropometric indices (weight, waist circumference, B.M.I.).

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Section: Effects On Bmisupporting

confidence: 83%

Section: Effect On Weightmentioning

confidence: 87%

Effect of cinnamon on blood sugar and anthropometric measurement in type two diabetes patients

Sadiq¹,

Abid²,

Jasim³

et al. 2021

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“…Cinnamon at present is considered one of the markets like a prophylactic supplement for insulin resistance, for metabolic syndrome, hyperlipidemia and arthritis ( Rafehi et al, 2012 , Medagama, 2015 ). Supplementation which contains cinnamon may significantly decrease all of DBP and SBP in people with type 2 diabetes ( Akilen et al, 2013a , Akilen et al, 2013b , Sengsuk et al, 2016 , Jamali et al, 2020 ). Intake cinnamon prevents biosynthesis as well as esterification all of triacylglycerol and cholesterol in healthy rats ( Lopes et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Addition Oats (Avena sativa) and Cinnamon on Cookies and their Biological Effects on Rats Treated with Cirrhosis by CCL4

Aly

Zaky

Mahmoud

et al. 2021

Saudi Journal of Biological Sciences

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“…The findings are consistent with several systematic reviews conducted on single herbs as well as Ayurveda as a whole system. ( Hardy et al, 2001 ; Yeh et al, 2003 ; Shekelle et al, 2005 ; Nahas and Moher, 2009 ; Shojaii et al, 2011 ; Sridharan et al, 2011 ; Suksomboon et al, 2011 ; Akilen et al, 2012 ; Allen et al, 2013 ; Gibb et al, 2015 ; Namazi et al, 2019 ; Peter et al, 2019 ; Jalali et al, 2020 ; Jamali et al, 2020 ) It should be noted that the majority of these Ayurvedic medicines are already in use in many countries, and many are used as dietary ingredients such as spices or foods. In many countries, Ayurvedic medicines are available over-the-counter (which includes online shopping) and are considered as dietary supplements.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3), Boswellia serrata Roxb. (−0.5; −0.7 to −0.4), Gynostemma pentaphyllum (Thunb.) Makino (−1; −1.5 to −0.6), Momordica charantia L. (−0.3; −0.4 to −0.1), Nigella sativa L. (−0.4; −0.6 to −0.1), Plantago ovata Forssk. (−0.9; −1.4 to −0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5), Trigonella foenum-graecum L. (−0.6; −0.9 to −0.4), and Urtica dioica L. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.

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Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials

Cited by 25 publications

References 34 publications

Effect of cinnamon on blood sugar and anthropometric measurement in type two diabetes patients

Effect of cinnamon on blood sugar and anthropometric measurement in type two diabetes patients

The Impact of Addition Oats (Avena sativa) and Cinnamon on Cookies and their Biological Effects on Rats Treated with Cirrhosis by CCL4

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

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