Effect of Cigarette Smoke Tar on the Hamster Pouch

Moore, Condict; Miller, Allison

doi:10.1001/archsurg.1958.01280230126020

Cited by 12 publications

(1 citation statement)

References 9 publications

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“…The cheek-poueh model has been used to examine the effeets of whole eigarette smoke and eigarette smoke condensates (Kreshover & Salley 1957, Tahah et al 1957, Moore & Miller 1958, Kendriek 1964. No tumours resulted from these experiments.…”

Section: ) Co-carcinogetiesismentioning

confidence: 99%

Animal models of infra‐oral chemical carcinogenesis: A review

Eveson

1981

J Oral Pathology Medicine

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Early attempts to induce malignant oral tumours were largely unsuccessful, us the oral mucosa is considerably more resistant to the actions of chemical carcinogens than skin. The first consistent success came when strong carcinogens were applied to the hamster cheek pouch. This model remains the most popular for studies of intra‐oral carcinogenesis and is discussed at length. The advantages and disadvantages are critically reviewed. The models of intra‐oral carcinogenesis in extra‐pouch sites in the hamster, mouse, rat and nonhuman primates arc considered. The possible reasons for the relative resistance of oral mucosa to chemical carcinogens are discussed, particularly in relation to portals of entry and saliva. Finally, the relative merits of the more popular models of intra‐oral carcinogenesis are briefly discussed.

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Section: ) Co-carcinogetiesismentioning

confidence: 99%

Animal models of infra‐oral chemical carcinogenesis: A review

Eveson

1981

J Oral Pathology Medicine

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The Effect of Cigarette-Smoke Condensate on Hamster Tissues

Moore¹,

Christopherson²

1962

Arch Surg

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Chemical carcinogenesis in the Syrian golden hamster:A review

Homburger¹

1969

Cancer

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The author reviews the literature since 1939 on carcinogenesis in hamsters. He analyzes Syrian hamster response to chemical carcinogens in comparison to the responses of other species, stressing interesting facets of the response of the hamster. It is his hypothesis that most contradictory observations made in the study of chemical carcinogenesis in random‐bred hamsters may be explained by genetic differences and that the study of this response in inbred pedigreed hamster lines will yield much information. The author believes that some correlation to the response of man to chemical carcinogens might be defined from such studies.

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Effect of Cigarette Smoke Tar on the Hamster Pouch

Cited by 12 publications

References 9 publications

Animal models of infra‐oral chemical carcinogenesis: A review

Animal models of infra‐oral chemical carcinogenesis: A review

The Effect of Cigarette-Smoke Condensate on Hamster Tissues

Chemical carcinogenesis in the Syrian golden hamster:A review

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