Chemical carcinogenesis in the Syrian golden hamster:A review

Homburger, F.

doi:10.1002/1097-0142(196902)23:2<313::aid-cncr2820230209>3.0.co;2-m

Cited by 30 publications

(13 citation statements)

References 94 publications

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“…In a series of publications since 1950, Kirkman and his co-workers have described that simultaneous administration of estrogens and androgens to Syrian hamsters effectively induces lieomyomas and lieomyosarcomas in the uterus of females and in the epididymal tail and adjacent ductus deferens of males [200][201][202][203][204][205][206][207][208][209]. The female animals also exhibit extensive endometrial hyperplasia [201].…”

Section: Uses Of Androgens In Womenmentioning

confidence: 86%

“…The female animals also exhibit extensive endometrial hyperplasia [201]. The hamsters receiving either estrogen or androgen alone do not develop these tumors, at least at the same time period, although androgen-treated animals develop papillary adenoma of uterus occasionally [202]. Simultaneous administration of androgen and estrogen to Syrian hamsters of either sex also induces malignant basal cell chaetepithelioma in the flank organs (scent glands) of the skin; this organ consists of many large sebaceous glands, hair follicles, and baskets of melanocytes around the growth cycles of the hair follicles [202;207;209-211].…”

Section: Uses Of Androgens In Womenmentioning

confidence: 93%

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Mechanisms for c-myc Induced Mouse Mammary Gland Carcinogenesis and for the Synergistic Role of TGF(alpha) in the Process

Liao¹

2001

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructior's, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and ABSTRACT (Maximum 200 Words)This project aims to elucidate the cell cycle basis on which c-myc oncogene induces mammary carcinogenesis and transforming growth factor o (tgfcx) promotes the process. Conduction of this training project will help the P.1. to develop his career in breast cancer research. Data obtained so far have shown that c-myc transgenic mammary tumors may develop specific foci that are more aggressive than their adjacent tumor areas and thus represent a second stage of tumor progression. c-Myc may induce E2F1 and cyclin A2 to initiate the tumor development, whereas overexpression of cyclins DI and E may occur as later events to promote tumor progression to a more aggressive phenotype. TGFcc may enhance c-Myc-induced mammary carcinogenesis by inducing cyclin DI and facilitating the loss of pRB expression, resulting in an earlier development of more aggressive tumors in tgfa/c-myc double transgeneic mice, compared to the c-myc tumors. These findings in the transgenic animals may have relevance to human breast cancer. INTRODUCTION:This subject of study aims to elucidate the cell cycle basis on which c-myc oncogene initiates mammary carcinogenesis and transforming growth factor (X (tgfa) promotes the process. Conduction of this training project will help the P.I., Dr. Dezhong Liao, to develop his career in breast cancer research. This research project has four tasks, each of which is consisted of two parts, i.e. in vivo studies with transgenic mice and in vitro studies with cultured cells. The four tasks are: "* Task 1. Study whether expression of E2F1 and cyclin A2 is induced to mediate mammary cancer formation in c-myc mice. (Months 1-15). "* Task 2. Investigate whether c-myc initially suppresses cyclin DI expression, but overexpression of cyclins DI and E occurs as later events to facilitate progression of tumors to faster growing phenotypes. (Months 1-15) "* Task 3. Study the mechanisms and the roles of overexpression of cyclins DI and E in mammary carcinogenesis in TGFc/c-myc mice. . "* Task 4. Investigate the mechanisms for the loss of pRB during mammary carcinogenesis in myc and TGFcu/c-myc mice. BODY:1. In vivo animal experiments on the cell cycle basis of c-myc-induced, tgfu.-enhanced mouse mammary carcinogenesis: We have actually started the project since this proposal was submitted to DOD in June of 1999, about one year earlier than the time when the award was started. During the past two years, ...

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Section: Uses Of Androgens In Womenmentioning

confidence: 86%

Section: Uses Of Androgens In Womenmentioning

confidence: 93%

Mechanisms for c-myc Induced Mouse Mammary Gland Carcinogenesis and for the Synergistic Role of TGF(alpha) in the Process

Liao¹

2001

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“…The development of an ideal animal model for cancer initiation and progression has been reviewed specially regarding the chemically induced oral cancer (21) (22,23) . Salley et al, (24 ) was the first to successfully induce squamous cell carcinoma in the hamster cheek pouch by painting (polycyclic hydrocarbon 9, 10 dimethyl-1, 2, benzanthracene (DMBA) dissolved in benzene or acetone.…”

Section: Discussionmentioning

confidence: 99%

Concordant VS. Discordant Xeno Cardiac Transplantation; The past, the present and future Trends

Sadeghi

2016

IJB

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There is a huge waiting list for recipient of heart for people in need of, yet the pool of donors are limited to less than 10% of all brain death cases coming out of road accidents. NHSA reports 2700 Transplants were harvested out of 55000 road accident brain deaths in 2014. A country (China) expects a record number of transplant this year mainly harvested from executed prisoners (world number one in execution followed by IRAN), despite a new ban applied this year (The south China Morning Post). So one of the most exciting donor pool which also is very close genetically to Human being is Baboon, in which we will try to reignite interest in research and development for farming and harvesting their organs for use in people in need of Cardiac Transplant.

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“…The final stage of carcinogenesis is the clinical manifestation of the lesion as a result of an intermediate phase called the progression stage. This process is characterized microscopically by an inflammatory reaction, hyperplasia and finally cellular dysplasia, progressing until the lesion is macroscopically evident (31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Carcinogenic Potential of Bleaching Agents in a DMBA Induction-model.

2000

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Chemical carcinogenesis in the Syrian golden hamster:A review

Cited by 30 publications

References 94 publications

Mechanisms for c-myc Induced Mouse Mammary Gland Carcinogenesis and for the Synergistic Role of TGF(alpha) in the Process

Mechanisms for c-myc Induced Mouse Mammary Gland Carcinogenesis and for the Synergistic Role of TGF(alpha) in the Process

Concordant VS. Discordant Xeno Cardiac Transplantation; The past, the present and future Trends

Evaluation of the Carcinogenic Potential of Bleaching Agents in a DMBA Induction-model.

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