Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

Zghari, Oussama; Rezqaoui, Ayoub; Ouakki, Sihame; Lamtai, Mouloud; Chaibat, Jihane; Mesfioui, Abdelhalem; Hessni, Aboubaker El; Rifi, El Housseine; Essamri, Azzouz; Ouichou, Ali

doi:10.4236/jbbs.2018.84012

Cited by 29 publications

(18 citation statements)

References 25 publications

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“…Our results showed that AlCl3 (in ADM group) impaired short term working memory, where spontaneous alternation behaviour (SAP) was reduced. This result supported with Xing et al (2018) and Zghari et al (2018) found that exposure of rat and mice to Al or AlCl3 and D-galactose reduced spontaneous alternation percentage in Y-maze test. While treatment with GS and MO enhanced the reduced SAP and this were in agreement with Kim et al (2017) and Omotoso et al (2018) who reported that red ginseng and ginsenoside moringa olifera increased alternation percent in Y-maze.…”

Section: Discussionsupporting

confidence: 84%

Ginseng and Moringa Olifera Ameliorated Cognitive Impairments Induced by Aluminium Chloride In Albino Rat

Abdelghany¹,

Khalil²,

Azeem³

et al. 2019

Adv. Anim. Vet. Sci.

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A dequate learning capability is essential for survival and social adaptation of human, animals and birds. Young animals must learn many things rapidly such as escaping from predators (Heckman, 2007). Hence, learning impairment by neurodegenerative disease such as Alzheimer's disease (AD) may threaten animal life. Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disorder which characterized by learning and memory impairments which caused by diminished level of acetylcholine, reduced biogenic amines, increased oxidative stress and antioxidant enzyme disturbance. In addition it characterized pathologically by brain size reduction, degeneration and death of hippocampal neurons, aggregations of senile amyloid plaques and tau proteins (Dobhal et al., 2013; Yin et al., 2013; Haider et al., 2014). Several In vivo studies were performed to assess the potential role of metals in the pathogenesis of AD, where an increase in aluminium (Al3+) and other metals concentrations were detected in several brain areas of rats administered aluminium chloride for six months (Fattoretti et al., 2004).

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Section: Discussionsupporting

confidence: 84%

Ginseng and Moringa Olifera Ameliorated Cognitive Impairments Induced by Aluminium Chloride In Albino Rat

Abdelghany¹,

Khalil²,

Azeem³

et al. 2019

Adv. Anim. Vet. Sci.

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“…A dose of 1 mg/kg CuCl 2 showed maximum anxiety-like and depression-like symptoms as compared to controls. The Cu effects observed in our study are similar to numerous heavy metals (Cd, Al and Ni)[7] [8][10].…”

supporting

confidence: 81%

“…Exposure to metals from environment, which are highly neurotoxic and have no other biological functions, such as aluminum (Al), lead (Pb) and cadmium (Cd), has long been debated as a potential environmental risk factor for mood disorders [7] [8]. However, nowadays, people are mainly focusing on biologically important metals such as copper (Cu), because their imbalance is related to a profound physiological alteration including the central nervous system (CNS) [9] [10].…”

Section: Introductionmentioning

confidence: 99%

Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

Lamtai¹,

Ouakki²,

Zghari³

et al. 2019

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As both deficiency and excess of copper (Cu) can be harmful, dysregulation in its homeostasis has been connected with various neurological disorders. The present study was undertaken to examine whether Cu chronic administration can induce alterations of affective behavior especially anxiety and depression levels in male and female rats. Twenty-four rats, for each gender, divided in control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or CuCl 2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. Results demonstrated that Cu administered chronically, exerts an anxiogenic effect in rats. In the OFT, Cu decreases the TCA and NRC parameters without modifying the locomotor activity represented by the NTS parameter. With regard to EPM, Cu decreases TOA and EOA parameters without modifying the TAE parameter. A significant increase in depression-like symptoms was also exhibited by Cu treated rats (p < 0.001). A dose of 1 mg/kg CuCl 2 showed maximum anxiety-like and depression-like symptoms as compared to controls as well as from the other two doses indicating dose-dependent effects of chronic Cu administration. Overall, these results suggest that intoxication with Cu has potentially deleterious effects on brain as reflected in behavioral dysfunctions such as depression and anxiety.

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“…The comportmental studies showed that chronic and sub chronic exposure to Aluminum causes an increased immobility time of rats in the forced swimming test; reflecting the depressed state of animal. This state is due to the reduction of serotonin level in central serotoninergic system [30], in cortex [9], hippocampus, striatum, and spinal cord brain regions of rat pups following oral exposure to Al 31 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Aluminium and Aqueous extract of Rosmarinus officinalis on rat Brain: Impact on Neurobehavioral and Histological study

Lahouel

Kharoubi

Boussadia

et al. 2020

J. Drug Delivery Ther.

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'Rosmarinus officilnalis' is a plant used in Mediterranean diet and traditional medicine, possessing various antioxidant and cytoprotective bioactivities. In this study, we investigated the potential neuroprotective efficacy of aqueous Rosemary extract (AER) against neurotoxicity induced by Aluminum (Al), in terms of behavioral, biochemical and histological aspects in young rats. an intraperitoneal injection of Al, at the weekly dose of 60mg/Kg was given to the animals. A treatment of 150mg/Kg/day of AER was administered by gavage over periods of 6 or 12weeks. Al caused intense changes over time in body and brain weight, increase in neurological disorders such as depression, anxiety, and deficiency in memory skills. Results show also disturbances in locomotors activity, with a significant inhibition of AchE and increase LDH activity compared to control. Additionally, Al induced structural damages in the cerebral cortex, and the CA1 region of hippocampus. However, treatment with AER resulted in improved depression and anxiety state, locomotors activity and restored memory skills. Results show that AER increase the AchE activity and decreased neuronal loss in the cerebral cortex and the CA1 region of hippocampus with the 6weeks treatment but induced disruption and structural modification of brain tissue after the 12 weeks treatment. The Aqueous extract of Rosemary possess a neuroprotector and corrective effect against neurological alterations induced by Aluminum, but when administered over a long period of time, the extract can cause a no beneficial effect and morphologic modifications in cerebral tissue and behavior test. Keywords: Rosmarinus officinalis, Aluminum, neuro-behavior, brain structure.

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Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

Cited by 29 publications

References 25 publications

Ginseng and Moringa Olifera Ameliorated Cognitive Impairments Induced by Aluminium Chloride In Albino Rat

Ginseng and Moringa Olifera Ameliorated Cognitive Impairments Induced by Aluminium Chloride In Albino Rat

Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

Effect of Aluminium and Aqueous extract of Rosmarinus officinalis on rat Brain: Impact on Neurobehavioral and Histological study

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