Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes.

Abstract

International statistics indicate that there is a close correlation between the consumption of saturated fats (dairy fats and meat fats) and the mortality from coronary heart disease (CHD), and this conception has been confirmed by many epidemiological studies. Such studies alone, however, cannot prove the existence of a cause-and-effect relationship between these two variables; dietary intervention trials are needed. The Finnish Mental Hospital Study was such a trial, conducted in two hospitals near Helsinki in 1959--1971. Practically total replacement of dairy fats by vegetable oils in the diets of these hospitals was followed by a substantial reduction in the mortality of men from CHD. Total mortality also appeared to be reduced. As to the causes of death other than CHD, none was significantly influenced by dietary change. This was also true for malignant neoplasms. To alleviate the burden of CHD on public health, many investigators have recommended important changes in the quantity and quality of dietary fats.

Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects

“…Nutrition-related epidemiological associations have shown significant direct correlations between dairy fat consumption and cardiovascular outcomes (Turpeinen, 1979;Renaud & de Lorgeril, 1989;Artaud-Wild et al, 1993). Of particular interest are the comments regarding cheese that appear to differentiate its effect on plasma cholesterol from other high-fat dairy foods.…”

“…The epidemiological association between national consumption of butter fat and cardiovascular mortality has been advanced as a key reason for reducing intake of full-cream dairy fat (Artaud-Wild et al, 1993). Earlier Turpeinen (1979) had also demonstrated a strong correlation (r ¼ 0.75) between dairy fat consumption in 22 countries and mortality from coronary heart disease (CHD). However, the possibility that not all full-cream fat dairy products influence plasma cholesterol identically has been rarely investigated.…”

The Community-Based Strategy to Prevent Coronary Heart Disease: Conclusions from the Ten Years of the North Karelia Project

“…All these studies indicated that a few factors-notably smoking, elevated serum cholesterol, and elevated blood pressure-predict a major part of subsequent CHD risk, inde pendent of other potential factor studied. Results from basic biochemical studies, as well as results from a few experimental and quasi-experimental studies on the different risk factors, have also long been available: for smoking cessation (8), for cholesterol-lowering diets (62), and for blood pressure treatment (63).…”

Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i> and <i>Peristrophe bicalyculata</i> in Alloxan-Induced Diabetic Rats

“…Coronary heart disease (CHD) is a major cause of morbidity and mortality worldwide. Epidemiological, genetic, laboratory animal and metabolic ward studies have provided evidence linking high blood cholesterol with atherosclerosis and CHD [23] [24]. While cholesterol is believed to be chiefly implicated in the relationship, serum triacylglycerols may also play a role [25].…”