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Hyptis verticillata is a medicinal plant reported to possess strong antioxidant activity growing in the American continent with no evidence of its cultivation in Nigeria. The present study was designed to investigate the phytocompounds present in n-hexane extract of the leaves of H. verticillata cultivated in Calabar, Cross River State, Nigeria. The phytochemicals found in relatively high amounts were flavonoids (19.67±1.53%), phenols (13.20±0.40 mg/g) and saponins (7.17±1.04%). Others including phytates (0.42±0.76 mg/g), cyanogenic glycosides (3.80±0.20%) and oxalates (2.01±0.09%) were present in low concentrations. The GC-MS (gas chromatography-mass spectrometry) analysis of the extract revealed fifteen bio-active compounds, mainly hydrocarbons, fatty acid esters and alcohols. The most predominant compounds were, 9,12,15-octadecatrienoic acid, 2,3-bis(acetyloxy) propyl ester (18.17%), 5-cholestene-3-ol, 24-methyl-(17.48%), 1-iodo-2-methylnonane (10.89%), glycerol 1,2-dipalmitate (8.19%), 1-pentadecene (5.18%), 1-hexadecene (4.80%) and methyl-14-methylpentadecanoate (4.76%). The chemical profile of H. verticillata grown in Nigeria is akin to that in the West, hence may serve for similar aromatic and medicinal purposes.

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In this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in allxoan-induced diabetic rats were investigated. Fifty four (54) adult male albino Wistar rats weighing between 140 -180 g were shared into 5 parallel groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group consisted of 6 rats. Groups 2 -5 were made diabetic using alloxan (

Aims: The effects of quercetin and Emilia sonchifolia on the lipid profile in Cadmium chloride induced oxidative stress were investigated in this study Methodology: Twenty-four (24) male albino Wistar rats aged 5-6 weeks old and weighing 100-170g were divided into four groups of six rats each; consisting of normal control group, CdCl2 untreated group, QE treated group and ES treated group. In the initial phase of the experiment called the induction phase, Group 1 being the NC group received distilled water orally and the rest of the experimental groups were orally administered CdCl2 at a dose level of 5mg/kg b.w/day for 21 days.  In the next phase of the experiment called the treatment phase Group 1 and 2 being the NC and CdCl2 untreated groups respectively, were orally administered 0.07ml of 2% tween80. Group 3 being QE treated group was administered quercetin at a dose level of 20mg/kg b.w/day + 0.07ml of 2% tween80. Group 4 being ES treated group was administered Emilia sonchifolia at a dose level of 575.8mg/kg b.w/day + 0.07ml of 2% tween80 for 28 days. After the treatment period of 28 days, the animals were fasted overnight, anesthetized and sacrificed. Whole blood was collected for biochemical assay. Results: Results showed that cadmium decreased body weight and significantly  increased serum levels of TG, TC, LDL-C and VLDL-C across the treatment  groups. Conclusion: Marked positive response were observed following treatment with quercetin and Emilia sonchifolia in all treated groups thus suggesting the hypolipidemic activities of quercetin and Emilia sonchifolia in cadmium induced oxidative stress.