Effect of Chlorpromazine on Serum Growth-Hormone Concentration in Man

Sherman, Lawrence; Kim, Sooseng; Benjamin, Fred; Kolodny, Howard D.

doi:10.1056/nejm197101142840203

Cited by 77 publications

(10 citation statements)

References 14 publications

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“…Thus, phentolamine blocks the secretion of HGH in response both to hypoglycaemia [5], and to dopamine [10], and propranolol may allow an increased secretion of HGH presumably by withdrawal of an inhibitory mechanism [5,6], Chlorpromazine is thought to act at a hypothalamic level, and has been shown both in rats and man to suppress GH response to hypoglycaemia [4,11], It has been shown to have an a-blocking effect in the CNS and may have other types of action antagonising catecholamines as well. It is probably important that chlor promazine, although rapidly absorbed and distributed, does not achieve high brain concentrations compared to other organs [12].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is no evidence from this study that a single dose of chlorpromazine 50 mg taken orally had any effect on the response of HGH to L-dopa. Sherman et al [11] showed that chlorpromazine 25 mg taken four times daily for seven days reduced but did not abolish the HGH response to insulin hypoglycaemia. Acute studies have been less clear cut.…”

Section: Discussionmentioning

confidence: 99%

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Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

et al. 1973

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

et al. 1973

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“…Further evidence for neural regulation of GH secretion is provided by the experiments of Takahashi and others (mentioned above) who find increased GH levels during stage 3 and 4 sleep. Short-term administration of chlorpromazine in man decreases fasting HGH and attenuates the GH response to insulin-induced hypoglycemia (148).…”

Section: Evidence For Neural Control Of Growth Hormone Secretionmentioning

confidence: 99%

Psychologic and Neural Regulation of Growth Hormone Secretion

Brown

Reichlin

1972

Psychosomatic Medicine

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A wide variety of stressful stimuli, both physical and psychologic, cause GH discharge in both man and monkey in a manner reminiscent of the changes in ACTH secretion under similar circumstances. The hypothalamus appears to mediate acute changes in GH release as evidenced by the finding that basal hypothalamic or infundibular lesions and pituitary stalk section blocked the acute GH response to hypoglycemia in rat, monkey and man. Changes in GH release in hypoglycemia, prolonged fasting and exercise after meals are related to caloric homeostasis. GH elevation, after stressful stimuli, may produce metabolic effects related to caloric requirements and has protective effects on tissues. The mechanisms for growth hormone release and adrenal corticoid activation are independent since dissociation of these two responses is found after a variety of stimuli in man and monkey. Growth hormone and adrenal discharge appear to have specific independent psychologic correlates.With the development of the sensitive radioimmunoassay for growth hormone (GH) in human plasma (1-5), detailed experimental studies on growth hormone regulation became possible for the first time (6). A number of findings based on preimmunoassay data (7-9) were confirmed, such as blockade of growth hormone release by hypothalamic lesions and increased release of GH in starvation. In a few instances, previous inferences were not validated. Whereas it had been assumed that

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“…Sher man el al. [17] found that CPZ blunted the rise in hGH produced by insulin hypoglycemia. There was a significant difference in basal hGH, but basal levels were so low -4 ng/ml without CPZ and 2 ng/ml with CPZ -that it is evident that biologically significant secretion was not oc curring either before or after CPZ.…”

Section: Discussionmentioning

confidence: 99%

Effect of Perphenazine on Secretory Patterns of Growth Hormone in the Rat

Redmond¹

1980

Neuroendocrinology

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A nonstressful frequent sampling technique was employed to determine the effect of perphenazine, 5 mg/kg on spontaneous secretion of rat growth hormone (rGH). The drug blocked secretion almost entirely for at least 3, but no more than 22 h. These results suggest a role for dopamine and/or norepinephrine as stimulatory neurotransmitters for spontaneous rGH secretory episodes. They further suggest that experimental or therapeutic use of phenothiazines might produce functional GH deficiency.

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Effect of Chlorpromazine on Serum Growth-Hormone Concentration in Man

Cited by 77 publications

References 14 publications

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

Psychologic and Neural Regulation of Growth Hormone Secretion

Effect of Perphenazine on Secretory Patterns of Growth Hormone in the Rat

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