Effect of Chewing Tobacco on Hematological Parameters in Bikaner City Population

Kumar, Dr Devendra

doi:10.18535/jmscr/v5i2.87

Cited by 10 publications

(11 citation statements)

References 17 publications

(16 reference statements)

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“…Insufficient pulmonary function in SLT consumers may impart a necessity of stimulating erythropoiesis for fulfilling the oxygen demands of the body. Thus the increase in PCV and Hb levels following such increase in erythrocyte production is quite awaited [8]. Decreases in total RBC, PT, Hb, and PCV levels were seen in SLT users when compared to nonusers and were statistically significant in the present study.…”

Section: Discussionsupporting

confidence: 47%

“…Tobacco is the dried and processed leaves of the plant Nicotiana tobacum that is widely cultivated and commercially grown in many countries of the world [8]. SLT contains three to four times more nicotine than that delivered by a cigarette and it stays for a longer time in the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

“…SLT products modulate the metabolic pattern in a robust way and escalate the risk of systemic inflammation such as RBC morphology modulation, polycythemia vera, and cardiovascular diseases. Indeed chromosomal instability resulting from SLT is most often studied in lymphocytes from peripheral blood [4, 8, 9].…”

Section: Introductionmentioning

confidence: 99%

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Smokeless Tobacco and Its Adverse Effects on Hematological Parameters: A Cross-Sectional Study

Shukla

Khaitan

Gupta

et al. 2019

Advances in Preventive Medicine

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Background. Smokeless tobacco (SLT) as a drug substance has been used throughout the world although it has dangerous effects on human health. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, increased apoptosis, and red blood cell (RBC) membrane damage. Therefore, the present study was undertaken to evaluate the adverse effects of SLT on hematological parameters and establish a correlation between them. Materials and Methods. A total of 100 subjects (50 SLT users and 50 nonusers) were selected for the study. Complete demographic data and history were taken and clinical examination was done to evaluate any oral mucosal changes. Venous blood samples were taken to analyze the hematological parameters. Results. Significant changes were observed in the complete blood profile in SLT users when compared to nonusers. All the hematological parameters had a negative correlation with form of SLT except for total leucocyte count which had a positive correlation. Conclusion. The current study confers an imperative role into SLT mediated effects on a complete hemogram and might be beneficial in spreading awareness against its usage. It also serves as a forewarning alarm among the population consuming SLT as an alternative to smoking tobacco.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smokeless Tobacco and Its Adverse Effects on Hematological Parameters: A Cross-Sectional Study

Shukla

Khaitan

Gupta

et al. 2019

Advances in Preventive Medicine

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“…Smokeless tobacco substances make the metabolic pattern modular strongly and increase the risk of systemic inflammation, for instance cardiac diseases, polycythemia vera, and modulation of RBC morphology. 9 Until now, very few studies 10 have identified the adverse effects on inflammatory markers (acute phase proteins) and blood profiles of the various forms of smokeless tobacco consumption and its proven correlation. A research deficit has been observed with respect to the interaction of SLT with CRP as well as hematological parameters in a population consuming SLT where rationally, SLT is highly prevalent and oral cancer and other systemic diseases are growing at an alarming rate.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

et al. 2021

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Objective: To investigate the changes in levels of C-reactive protein (CRP) and hematological parameters among smokeless tobacco (SLT) users. Methods: A comparative cross-sectional study was conducted at the community level in the coastal districts of Sindh province namely Badin, Thatta, and Sujawal from January 2017 to December 2019. The CRP and hematological parameters were evaluated by well-established methods among SLT and non-SLT users. Results: There was a statistically significant difference between SLT users (mean CRP = 0.77) versus non-users (mean CRP = 0.18), p = <0.001. Among hematological parameters, white blood cells (SLT users median = 7.85 versus non-SLT users median = 8.50, p = 0.004), monocytes (SLT users median = 6.00 versus non-SLT users median = 6.00, p = 0.001) and erythrocyte sedimentation rate (SLT users median = 15.00 versus non-SLT users median = 10.00, p = 0.006) showed statistically significant difference. Conclusions: Significantly elevated CRP was observed in SLT users similarly hematological parameters also showed changes. WBCs, monocytes and ESR were significantly deranged among SLT users. Further studies looking into long term effects of these changes would be helpful. doi: https://doi.org/10.12669/pjms.37.4.3841 How to cite this:Memon SM, Kumar N, Atta-Ur-Rahman A, Syed BM. Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3841 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…In another previous study (Kumar et al, 2017) observed that Hb, RBC and WBC count were signi icantly increased, whereas; lymphocytes, monocytes and platelet count were signi icantly decreased in tobacco chewers as compared to controls. The indings of Ukoha indicated that chronic tobacco consumption might put the body at some risk of adverse hematological and haemostatic conditions (Ukoha et al, 2012).…”

Section: Resultsmentioning

confidence: 77%

Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

Thorat

Joshi

Wingkar

2021

ijrps

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The present study was aimed to evaluate the effect of Vitamin C (VC) supplementation on hematological parameters in Smokeless Tobacco (ST) chewers. A total of 338 subjects aged between 31 to 60 years (168 ST chewers and 170 ST non-chewers) participated in the present study. ST chewers were further divided into 3 subgroups with respect to ST chewing duration in years. Subjects of both the groups were examined at the baseline study and after 45 days of supplementation of 1 g of Vitamin C (VC) for hematological parameters. WBC count (p=0.04), granulocytes % (p=0.0007), HCT (p=0.01) and MCV (p=0.04) were significantly increased whereas, monocytes % (p=0.002) and platelet count (p<0.0001) were significantly decreased in ST chewers as compared to controls. After supplementation of VC, WBC count (p<0.001) and granulocytes % (p<0.0001) were significantly decreased and lymphocytes % (p=0.008), monocytes % (p<0.0001), RBC count (p=0.01) and Hb content (p=0.006) were significantly increased in ST chewers as compared to their baseline values. In conclusion, the use of ST had deleterious effects on hematological parameters; however, supplementation of 1 g of VC showed protective effects on hematological parameters.

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Effect of Chewing Tobacco on Hematological Parameters in Bikaner City Population

Cited by 10 publications

References 17 publications

Smokeless Tobacco and Its Adverse Effects on Hematological Parameters: A Cross-Sectional Study

Smokeless Tobacco and Its Adverse Effects on Hematological Parameters: A Cross-Sectional Study

Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

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