Effect of cerivastatin on peripheral capillary permeability to albumin and peripheral nerve function in diabetic rats

Rosuvastatin positively changes nerve electrophysiology in diabetic rats

“…In addition, in our model, nerve conduction velocities became markedly reduced only after 6 months of diabetes, due to the protection of neural growth during maturation [20,21]. This was shown using the same model in which we previously reported a trend towards an improvement in peripheral nerve conduction after short-term treatment with cerivastatin [15].…”

“…We have already reported a significant association between an increase in capillary filtration and peripheral neuropathy in diabetic patients [12], which is consistent with the role of endoneurial swelling in the decrease in peripheral nerve conduction [15]. The beneficial effect of rosuvastatin on the latency of only the fastest sensory fibres suggests that these fibres are more prone to endoneurial swelling and may be influenced favourably by treatment that is able to normalize capillary permeability.…”

“…Moreover, in electrophysiological technique, CMAP amplitude is recorded only on the muscle (18) painful myopathy and muscle weakness have been described during statin treatment in the presence or absence of associated neuropathy [23,24]. In our previous study, diabetic rats treated by high doses of cerivastatin were affected by muscle weakness [15]. In addition, attention has already been drawn to the occurrence of muscle toxicity without an increase in CPK levels [25].…”

“…Similarly, in rats with early STZ-induced diabetes, short-term treatment by cerivastatin partly prevents impairment of peripheral nerve conduction [15]. Some recent data also suggest that the beneficial effects of statins might result from restoration of vasa nervorum [8].…”

“…In this respect, we have recently shown that cerivastatin and rosuvastatin may prevent the increase in peripheral Capillary Filtration of Albumin (CFA) in rats with early STZ-induced diabetes [15,16]. This effect appeared to be independent of blood pressure and lipid changes [16].…”