Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes

Tarhzaoui, K.; Valensi, P.; Boulakia, Francine Cohen; Lestrade, R.; Albertini, Jean-Paul; Béhar, A.

doi:10.1016/j.diabres.2008.01.005

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…). There were 18 studies on mice , 61 on rats , and 41 on rabbits . This corresponds to 66 (55%) prospective controlled trials and 54 (45%) randomized controlled trials (RCTs).…”

Section: Resultsmentioning

confidence: 99%

Most appropriate animal models to study the efficacy of statins: a systematic review

Pecoraro

Moja

Dall’Olmo

et al. 2014

Eur J Clin Investigation

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“…). There were 18 studies on mice , 61 on rats , and 41 on rabbits . This corresponds to 66 (55%) prospective controlled trials and 54 (45%) randomized controlled trials (RCTs).…”

Section: Resultsmentioning

confidence: 99%

Most appropriate animal models to study the efficacy of statins: a systematic review

Pecoraro

Moja

Dall’Olmo

et al. 2014

Eur J Clin Investigation

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“…The improvement in sensory nerve conduction during rosuvastatin treatment has been shown to be associated with an improvement in nerve blood flow [22] and restoration of vasa nervorum [8] In our model of rats with early induced diabetes, rosuvastatin prevents the increase in peripheral capillary filtration of albumin independently from blood pressure and lipid changes [16]. We have already reported a significant association between an increase in capillary filtration and peripheral neuropathy in diabetic patients [12], which is consistent with the role of endoneurial swelling in the decrease in peripheral nerve conduction [15].…”

Section: Discussionmentioning

confidence: 96%

“…In this respect, we have recently shown that cerivastatin and rosuvastatin may prevent the increase in peripheral Capillary Filtration of Albumin (CFA) in rats with early STZ-induced diabetes [15,16]. This effect appeared to be independent of blood pressure and lipid changes [16].…”

mentioning

confidence: 96%

Rosuvastatin positively changes nerve electrophysiology in diabetic rats

Tarhzaoui¹,

Valensi²,

Léger³

et al. 2009

Diabetes Metabolism Res

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“…(2003) first demonstrated that rosuvastatin treatment improved endothelium‐dependent NO‐mediated relaxations in aortae of streptozotocin‐induced diabetic mice. Recently, rosuvastatin has been shown to normalize endothelial function of aortae in streptozotocin‐induced diabetic rats (Schafer et al ., 2007; Tarhzaoui et al ., 2008). Treatment with simvastatin preserved endothelial function in large and small coronary vessels of high cholesterol‐fed pigs (Wilson et al ., 2001).…”

Section: Discussionmentioning

confidence: 99%

Rosuvastatin improves endothelial function in db/db mice: role of angiotensin II type 1 receptors and oxidative stress

Tian¹,

Wong²,

et al. 2011

British J Pharmacology

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BACKGROUND AND PURPOSEHMG-CoA reductase inhibitors, statins, with lipid-reducing properties combat against atherosclerosis and diabetes. The favourable modulation of endothelial function may play a significant role in this effect. The present study aimed to investigate the cellular mechanisms responsible for the therapeutic benefits of rosuvastatin in ameliorating diabetes-associated endothelial dysfunction. EXPERIMENTAL APPROACHTwelve-week-old db/db diabetic mice were treated with rosuvastatin at 20 mg·kg -1 ·day -1 p.o.for 6 weeks. Isometric force was measured in isolated aortae and renal arteries. Protein expressions including angiotensin II type 1 receptor (AT1R), NOX4, p22 phox , p67 phox , Rac-1, nitrotyrosine, phospho-ERK1/2 and phospho-p38 were determined by Western blotting, while reactive oxygen species (ROS) accumulation in the vascular wall was evaluated by dihydroethidium fluorescence and lucigenin assay. KEY RESULTSRosuvastatin treatment of db/db mice reversed the impaired ACh-induced endothelium-dependent dilatations in both renal arteries and aortae and prevented the exaggerated contractions to angiotensin II and phenylephrine in db/db mouse renal arteries and aortae. Rosuvastatin reduced the elevated expressions of AT1R, p22 phox and p67 phox , NOX4, Rac1, nitrotyrosine and phosphorylation of ERK1/2 and p38 MAPK and inhibited ROS production in aortae from db/db mice. CONCLUSIONS AND IMPLICATIONSThe vasoprotective effects of rosuvastatin are attributed to an increase in NO bioavailability, which is probably achieved by its inhibition of ROS production from the AT1R-NAD(P)H oxidase cascade. AbbreviationsAng II, angiotensin II; AT1R, angiotensin II type 1 receptor; DHE, dihydroethidium; eNOS, endothelial NOS; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; L-NAME, N G -nitro-L-arginine methyl ester; RAAS, renin-angiotensin-aldosterone system; ROS, reactive oxygen species; SNP, sodium nitroprusside BJP British Journal of Pharmacology

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Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes

Cited by 7 publications

References 39 publications

Most appropriate animal models to study the efficacy of statins: a systematic review

Most appropriate animal models to study the efficacy of statins: a systematic review

Rosuvastatin positively changes nerve electrophysiology in diabetic rats

Rosuvastatin improves endothelial function in db/db mice: role of angiotensin II type 1 receptors and oxidative stress

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