Effect of ceramic filler content on the mechanical and thermal behaviour of poly-l-lactic acid and poly-l-lactic-co-glycolic acid composites for medical applications

Damadzadeh, Behzad; Jabari, Hamideh; Skrifvars, Mikael; Airola, Karri; Moritz, Niko; Vallittu, Pekka K.

doi:10.1007/s10856-010-4110-9

Cited by 59 publications

(50 citation statements)

References 21 publications

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“…Composite scaffolds are in general a combination of biomaterials. For example, a combination of ceramic and polymer scaffold [13] or a combination of ceramic, synthetic polymer and natural polymer biomaterials [14]. Since natural biomaterials lack the required mechanical strength, a collagen and nano-hydroxyapatite-based scaffold with adequate mechanical strength having high porosity and interconnected pore structure is a valid model [15].…”

Section: Scaffoldsmentioning

confidence: 99%

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

Bhattacharya¹,

Ghayor²,

Weber³

2016

Transfus Med Hemother

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2500 years ago, Hippocrates realized that bone can heal without scaring. The natural healing potential of bone is, however, restricted to small defects. Extended bone defects caused by trauma or during tumor resections still pose a huge problem in orthopedics and cranio-maxillofacial surgery. Bone tissue engineering strategies using stem cells, growth factors, and scaffolds could overcome the problems with the treatment of extended bone defects. In this review, we give a short overview on bone tissue engineering with emphasis on the use of adipose tissue-derived stem cells and small molecules.

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Section: Scaffoldsmentioning

confidence: 99%

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

Bhattacharya¹,

Ghayor²,

Weber³

2016

Transfus Med Hemother

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“…This would be due to the strong hydrophobicity and low degradability of PLLA. The extra methyl group in the PLLA repeating unit reduces its molecular affinity to water and leads to slow hydrolysis [30]. Therefore, the penetration of TBS into the composite is very slow and it takes a long time for the particles embedded in the PLLA matrix to be exposed to TBS.…”

Section: Ion Release Behaviormentioning

confidence: 99%

“…PLLA and PDLLG belong to the family of linear aliphatic polyesters, which are often used to prepare bioactive composites. The extra methyl group in the PLLA repeating unit reduces its molecular affinity to water and leads to a slow degradation [30]. PDLLG with its higher fraction of glycolide units is likely to hydrate and swell faster than PLLA and also to degrade faster [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Dissolution behavior of Mg/Si-doped vaterite particles in biodegradable polymer composites

Zhou¹,

Kasuga²

2018

Express Polym. Lett.

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Abstract. Tuning the ion release ability of bioactive materials is one of the key factors for bone repair and regeneration. Calcium (Ca 2+ ), magnesium (Mg 2+ ), and silicate ions were reported to enhance the activity of bone-forming cells. In this work, the dissolution behavior of magnesium-and silicate-doped calcium carbonate (vaterite), denoted as MgSiV, embedded in three kinds of biodegradable polymers in Tris buffer solutions (TBS) were examined to find an effective ion releasing system. Poly(L-lactic acid) (PLLA) and poly(D,L-lactide-co-glycolide) (PDLLG, lactide:glycolide = 75:25 or 50:50; denoted as PDLLG75 and PDLLG50, respectively) were chosen as the matrix polymers. The Mg 2+ and silicate ions were released rapidly within 3 d of soaking. Continuous release of Ca 2+ ions from the composites induced the formation of aragonite on the film surfaces in the presence of Mg 2+ ions. The amount of ions released from the MgSiV-PLLA composite was lesser than those released from the PDLLG-based composites. The fast degradation of PDLLG50 induced a decrease in the pH of TBS. The MgSiV-PDLLG75 composite exhibited a rapid release of Mg 2+ ions, a continuous release of Ca 2+ ions, and a controlled release of silicate ions with no reduction in the pH of TBS. Such release phenomena are caused by the formation of pathways for ion release, originating from the water uptake ability of PDLLG75.

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“…Despite the fact that there are a few reports dealing with the influence of filler content or preparation conditions on the properties of PLLA and its nanocomposites, data on the joint effects of these factors on composites based on PLLA and calcium phosphate ceramics intended for use in orthopedic applications are quite limited . Therefore, the intention of this work was to give a wide and complex depiction regarding the combined influence of the initial preparation conditions and filler content on the structure, crystallinity and thermal properties of PLLA and HAp/PLLA nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

The influence of the preparation conditions and filler content on thermal properties of poly-l -lactide and hydroxyapatite/poly-l -lactide nanocomposite

Miličević

Suljovrujić

2017

Polym. Int.

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Poly‐l‐lactide (PLLA) and hydroxyapatite/poly‐l‐lactide (HAp/PLLA) are two widely used biomaterials for three‐dimensional scaffolds, drug release matrices and implantable medical devices for reparation of bone tissue; diversity in the initial preparation and filler content has a significant influence on different properties such as morphology and crystallinity, thus playing a considerable role in most of these applications. For this reason, PLLA and HAp/PLLA samples with a large difference in crystallinity (from below 20% to over 70%) and filler content (up to 86 wt% of HAp nanoparticles with an average diameter of 80 nm) were prepared and consequent dissimilarities in morphology, crystallinity and thermal properties were investigated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), wide angle X‐ray diffraction (WAXD) measurements and Fourier transform infrared (FTIR) spectroscopy. Special attention was devoted to analyzing data obtained from thermal measurements. A three‐phase model was employed in order to describe the heat capacity step decline in the nanocomposite; the evolution in different polymer fractions, the crystalline fraction and the mobile and rigid amorphous fractions, with filler content was determined. © 2017 Society of Chemical Industry

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Effect of ceramic filler content on the mechanical and thermal behaviour of poly-l-lactic acid and poly-l-lactic-co-glycolic acid composites for medical applications

Cited by 59 publications

References 21 publications

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

Dissolution behavior of Mg/Si-doped vaterite particles in biodegradable polymer composites

The influence of the preparation conditions and filler content on thermal properties of poly-l -lactide and hydroxyapatite/poly-l -lactide nanocomposite

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