Effect of Celery (Apium Graveolens) on The Reduction of Blood Pressure: A Systematic Review

Abstract

Background: High blood pressure, also called hypertension, is one of the most common causes of early death in symptom-free adults. About 75 to 80% of the world population use herbal medicines for primary health care because of their better acceptability with human body and lesser side effects. Celery or Apium graveolens is a plant from the family of Apiaceae that has been used to lower blood preasure. This study aimed to review systematically the effect of Apium graveolens on the reduction of blood pressure. Subjects and Method: This was a systematic review. The theme of this study was the benefits of non-pharmacological treatment of celery extract in hypertensive experimental animal. A total of 6 articles were obtained from Science Direct, CINAHL, Pub Med, Elsevier (SCOPUS), and Pro Quest databases. Articles were specified based on inclusion and exclusion criteria. The inclusion criteria were articles published in English, time period around 2008 to 2018, quantitative study, non-duplicate articles published by Science direct, CINAHL, Pub Med, Elsevier (SCOPUS), and Pro Quest, and obligated to the objective of this study. Results: Celery extract had a significant effect to help lower the blood pressure in hypertension. The celery was extracted with ethanol, hexane, ethyl acetate, methanol, and pure water. All study were used laboratory experiments method with experimental animal. Most of them showed hypotensive effects through bradycardia and vasodilation from the administration of celery extract. Conclusion: Celery extract has a significant effect to help lower the blood pressure in experimental animal with hypertension.

Etnomedisin Obat Hipertensi di Kabupaten Kebumen

“…Jintem hitam sudah banyak dilakukan dilakukan uji klinik (Ahmad et al, 2013). Delima sudah dilakukan uji klinik tahap awal (Asgary et al, 2013) Ciplukan masih dalam tahap uji pre klinik (ishak, 2019) Belimbing wuluh masih dalam tahap uji pre klinik (Soncini et al (Ashraf et al, 2013) Alangalang sudah dilakukan uji pre klinik (Ruslin et al, 2013) Bunga Rosella sudah dilakukan uji klinik untuk hipertensi (Ritonga, 2017)(AbdelRahman & Shayoub, 2016 ; demikian juga seledri sudah dilakukan uji klinik untuk hipertensi (Marsita, 2019) (Kooti et al, 2014). Ubi jalar sudah banyak dilakukan uji pre klinik tetapi efek antihipertensi belum pernah di uji preklinik (Panda & Sonkamble, 2012).…”