Effect of Ceftriaxone on Isolated Smooth, Cardiac Muscles and Neuromuscular Junctions

Elsayed, Mohamed L.; Elkomy, Ashraf Ahmed; Aboubakr, Mohamed

doi:10.5455/ijavms.20110601104655

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…These obtained results were similar to the fact that cefeperazone in vivo enhanced the ileal motility in guinea pigs at 62.5 and 125 mg/kg, respectively, and promoted gastrointestinal propulsion of barium sulfate meal in mice at 1000 mg/kg and in vitro enhanced slightly the motility of isolated rabbit's gastrointestinal tract at 0.001 g/mL [ 15 ]. Also these findings were similar to the fact that the spontaneous motility of smooth muscle in situ was temporarily increased with 800 mg/kg cefminox when administered intravenously and in upper doses [ 16 , 17 ]. In contrast, cefadroxil had no effects on the isolated smooth muscle organs and the passage of charcoal meal in mice [ 18 ].…”

Section: Discussionsupporting

confidence: 78%

Some Pharmacodynamic Aspects of Cefepime

Elsayed

Elkomy

Elbadawy

2013

Journal of Pharmaceutics

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Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

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Section: Discussionsupporting

confidence: 78%

Some Pharmacodynamic Aspects of Cefepime

Elsayed

Elkomy

Elbadawy

2013

Journal of Pharmaceutics

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“…Whereas, in high dose treated groups (400 mg of CPFX ® /kg/day), necrosis of pancreatic tissue was observed after 7 days of administration. Elsayed et al (2013) studied the effect of CPFX ® on isolated smooth and cardiac muscles and as well as neuromuscular junctions and conclude that CPFX ® acts directly to induce neuromuscular blockade and scarcely possess pharmacological properties which might be leading to sever adverse reaction in clinical use. Moreover, functional and structural damage of rat submandibular and parotid glands was also reported in acute experiments following application of CPFX® and ofloxacin as single intraperitoneal injection at doses of 20, 40, and 80 mg/kg (Abdollahi & Isazadeh, 2001; Abdollahi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The Prospective Effect of Cinnamon and Chia on Submandibular Salivary Glands After Ciprofloxacin Administration in Albino Rats (Histological, Histochemical, and Ultrastructural Study)

Abd-Elmonsif

El-Zainy

Rabea

et al. 2022

Microscopy and Microanalysis

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Ciprofloxacin (CPFX®) is potent fluoroquinolone but has severe side effects. Cinnamon (CIN) and chia seeds are potent antioxidants. The current work aimed to compare the effect of CIN extract and chia seeds on CPFX®-treated submandibular salivary glands (SMGs). Thirty-two male albino rats were divided into four groups: Group 1: received saline. Group 2: received CPFX®. Group 3: received CIN extract after 4 h of CPFX® administration. Group 4: received ground chia seeds after 4 h of CPFX® administration. After 10 days, histological, histochemical, and ultrastructural examinations were done. Different examinations illustrated normal features of SMG in Groups 1 and 3. Group 2 showed degenerative signs. Group 4 showed normal features in some areas. Statistical results illustrated that Group 2 had highest mean vacuolation area%. Highest mean of PAS optical density (OD) was for Group 2. Concerning mercuric bromophenol blue stain OD; Group 1 showed highest mean OD. CPFX® has the deteriorative effect on SMG structure and ultrastructure. It leads to increased levels of glycosaminoglycans (GAGs) and decreased levels of total proteins. CIN extract showed more ameliorative effect compared to chia seeds.

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Effect of Ceftriaxone on Isolated Smooth, Cardiac Muscles and Neuromuscular Junctions

Cited by 2 publications

References 7 publications

Some Pharmacodynamic Aspects of Cefepime

Some Pharmacodynamic Aspects of Cefepime

The Prospective Effect of Cinnamon and Chia on Submandibular Salivary Glands After Ciprofloxacin Administration in Albino Rats (Histological, Histochemical, and Ultrastructural Study)

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