Effect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C

Abstract

To examine the efficacy of a cognitive-behavioral intervention (CBT) to prevent depression among methadone maintenance patients undergoing antiviral treatment for hepatitis C (HCV), 29 patients beginning HCV treatment were randomized to CBT or standard care (SC). Study participants did not meet criteria for major depressive disorder at the time of study recruitment. CBT did not result in less depression-related antiviral treatment failure, better adherence to antiviral treatment, or better HCV RNA outcomes. There were no significant treatment group differences on depressive symptoms over time. The CBT group did display a greater and more consistent decline in both BDI-II and HAM-D scores over time (d=.85 on the BDI-II; d=.72 on the HAM-D).

The Effectiveness of Nursing Intervention Program on Emotional Distress, Self-Efficacy, and Liver Enzymes Among Hepatitis C Virus Patients Undergoing Antiviral Treatment Therapy (Sovaldi Medication)

“…The reference [36] mentioned that; "sever anxiety is a very common side effects in clinical trial in 30% or more of patients and if patients are aware that medications predispose them to anxiety and learn how to deal with it, they can control anxiety more effectively". These were consistent with the results of the present study which revealed that there was a highly statistically significant improvement of emotional distress as regarding to (anxiety) at 0.024 post program than preprogram in which the percentage of patients who have no anxiety preprogram (42%) increase to 60% and also the patient who have mild anxiety reduced from 30% to 20% and moderate anxiety reduced from 28% to 10% post program than before the program; this could be as a result of stress management training session which taught them to control anxiety, to express negative feeling, and to cope more effectively with stress.…”

HIV transmission from drug injectors to partners who do not inject, and beyond: Modelling the potential for a generalized heterosexual epidemic in St. Petersburg, Russia

“…Non-IDUs who form partnerships with IDUs are called PIDUs (non-injecting partners of IDUs); other non-IDUs are PPIDUs. Following current treatment and cessation rates in Russia, IDUs in our model do not cease injecting and female PIDUs may begin injecting while with a male IDU partner (Butler, 2003; Krupitsky et al, 2006; Torban et al, 2011). Full details of the network model are in Supplementary Material.…”

Understanding clinical risk decision making regarding development of depression during interferon-alpha treatment for hepatitis-C: A qualitative interview study

“…Furthermore, many patients are reluctant to take psychoactive medication, particularly given an often prolonged history of drug abuse. Other treatment options include psychiatric interventions which have been suggested to reduce depressive symptoms (Farber et al, 2005, Neri et al, 2010 and cognitive behavioural therapy which has been successfully used to prevent the development of depression during treatment (Ramsey et al, 2011). Given that prophylactic treatment with antidepressants is not an option for all patients and that preventative interventions are not commonly offered, it is important for nursing staff to be able to detect the development of IFN-α-induced-depression in order to provide patients with the correct support.…”