EFFECT OF Cayratia trifolia L (Domin) EXTRACT ON REDUCED EXPRESSION OF MATRIX METALLOPROTEINASE-9 (MMP–9) AND VASCULAR ENDOTHELIAL GROWTH FACTOR –A (VEGF-A) IN WHITE RATS WITH BREAST CANCER

Dewi, Devi Cynthia; Sudiana, I Ketut

doi:10.20473/fmi.v52i1.5206

Cited by 3 publications

(2 citation statements)

References 9 publications

(10 reference statements)

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“…The interleukin-6 (IL-6) can activate JAK and increase STAT3 then increase VEGF expression, thereby, increasing angiogenesis. (Dewi et al, 2017) The interleukin-6 (IL-6) can also activate the Erk ½ cascade and decrease the protein E-cadherin. So, it affects the cohesion of cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Interleukin-6 serum levels in metastatic breast cancer and non-metastatic breast cancer

Adhiatma

Ali

Ghoib

2022

ijhs

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Introduction: This study has investigated the correlation between IL-6 serum levels with distant metastatic breast cancer incidence. Methods: We recruited female breast cancer patients at Dr. Soetomo General Hospital from March until May 2022. The sample was divided into 2 groups that consist Metastatic Breast Cancer (MBC) and non-MBC. After the stage, the IL-6 serum levels were measured. The study design was an observational analytic study, comparative analytics by comparing IL-6 serums levels in both groups: MBC and non-MBC. Results: Sixty patients, with the Non-Specific type being the common histopathology type found in this study (85%). We found 29 patients with metastases and 31 patients without metastases. Overall analyses identify Patient with high IL-6 serum levels had a 2.54 times higher chance of having a metastasis than patients with low IL-6 serum levels (95% CI = 1.39-4.63). Conclusions: Subjects with IL-6 serum levels >15.495 pg/mL had a higher risk for incidence of metastatic. The IL-6 serum levels may be a potential biomarker to predict metastases in breast cancer patients.

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Section: Resultsmentioning

confidence: 99%

Interleukin-6 serum levels in metastatic breast cancer and non-metastatic breast cancer

Adhiatma

Ali

Ghoib

2022

ijhs

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“…Pemberian ekstrak etanol C. trifolia selama 4 minggu berturut-turut mampu menurunkan ekspresi Matrixmetalloproteinase-9 (MMP-9) dan Vascular Endothelial Growth Factor (VEGF), yang merupakan protein yang memicu pertumbuhan jaringan darah baru sehingga kanker mampu tumbuh dan menyebar luas di dalam tubuh. Menurunnya ekspresi kedua protein tersebut menyebabkan perkembangan dan penyebaran kanker dapat dihambat [36].…”

Section: Antiangiogenesisunclassified

Galing (Cayratia trifolia L.): Sebuah Kajian Biologi, Fitokimia, dan Aktivitas Farmakologi

Feriadi¹,

Muhtadi²,

Barliana³

2019

Pharmauho

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Galing (Cayratia trifolia L.) merupakan salah satu tumbuhan liar yang mayoritas terdapat di Asia Tenggara, termasuk Indonesia. Galing secara empiris telah banyak digunakan untuk mengobati berbagai macam penyakit. Hampir semua bagian dari tumbuhan galing dapat dimanfaatkan sebagai obat tradisional. Beberapa penelitian telah dilakukan untuk membuktikan aktivitas farmakologis dari tumbuhan galing. Oleh karena itu, tinjauan ini bertujuan untuk menyajikan informasi mengenai tumbuhan galing, baik secara biologi, fitokimia maupun aktivitas farmakologisnya.Kata kunci: Herbal, galing, Cayratia trifolia, obat tradisional, farmakologi

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Potential of Curcumin-Quercetin Loaded Nanostructured Lipid Carriers as Oral Squamous Cell Carcinoma Adjuvant Therapy by Downregulating AKT/PI3K Signaling Pathway

Nugraha

Yudianto

Anwar

et al. 2022

RJPT

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Introduction: Oral squamous cell carcinoma (OSCC) is an oral epithelial neoplasm with worldwide prevalence of 95% among all oral malignancies. Therapy of OSCC include radiation, chemotherapy, and surgery but causes subsequent cell death, ineffective long-term therapy, and infection risk at surgical site. Curcumin-quercetin is flavonoid derived from Curcuma longa and Allium cepa that can induce apoptosis and inhibit cells metastasis. Combination of curcumin-quercetin has low solubility hence encapsulated by nanoparticle is necessary. Nanostructured lipid carriers (NLCs) can enhance loading capacity and improve stability of curcumin-quercetin, biocompatible, and enhance site-specific targeting efficiency. Administration of combination of curcumin-quercetin loaded nanostructured lipid carrier by injection targeting OSCC cell. Purpose: To analyze the potency of curcumin-quercetin loaded NLCs as OSCC therapy by downregulating AKT/PI3K signaling pathway. Discussion: Curcumin-quercetin loaded NLCs are injected into the body then reach the target cells. This combination later would be encapsulated releasing curcumin-quercetin. Curcumin-quercetin suppresses the AKT/PI3K signaling pathway which is considered as strong cell cycle inductor, inhibitor of pro-apoptotic proteins expression, and has a pivotal role in OSCC metastasis. Inhibition of the pathway decreases the expression of cyclin A/D/E and manifests in the G1/G2/M phase arrest. This condition accompanied by p53 and FOXO-1 expression leads to apoptosis. Downregulating of this pathway decreases NF-kB expression then the expression of MMP-2/9 is lowered and manifests in inhibition of extracellular matrix degradation. This condition leads to migration and metastasis inhibition. Conclusion: Curcumin-quercetin loaded NLCs is potential for OSCC therapy by downregulating AKT/PI3K signalling pathway.

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EFFECT OF Cayratia trifolia L (Domin) EXTRACT ON REDUCED EXPRESSION OF MATRIX METALLOPROTEINASE-9 (MMP–9) AND VASCULAR ENDOTHELIAL GROWTH FACTOR –A (VEGF-A) IN WHITE RATS WITH BREAST CANCER

Cited by 3 publications

References 9 publications

Interleukin-6 serum levels in metastatic breast cancer and non-metastatic breast cancer

Interleukin-6 serum levels in metastatic breast cancer and non-metastatic breast cancer

Galing (Cayratia trifolia L.): Sebuah Kajian Biologi, Fitokimia, dan Aktivitas Farmakologi

Potential of Curcumin-Quercetin Loaded Nanostructured Lipid Carriers as Oral Squamous Cell Carcinoma Adjuvant Therapy by Downregulating AKT/PI3K Signaling Pathway

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