Effect of cation–anion balance in feed on urine <scp>pH</scp> in rabbits in comparison with other species

Heer, F.; Dobenecker, Britta; Kienzle, Ellen

doi:10.1111/jpn.12653

Cited by 5 publications

(8 citation statements)

References 40 publications

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“…There could be strain differences in the absorption of dietary cations and anions from the gastrointestinal tract. The activity of carboanhydrase, the enzyme for renal H + excretion, plays a role in the potential change in urinary pH [4]. The possibility of strain differences in expression of this enzyme should be considered.…”

Section: Discussionmentioning

confidence: 99%

“…The diets were analyzed for minerals (Table 1) and the DCAB was calculated from these values using the following equation [1,3,4,6] Once a week, during the cage changing, spontaneous urination is known to occur [27,28]. This behavior was used to collect as much urine as possible per mouse without stressful or invasive manipulation.…”

Section: Feeding Trialmentioning

confidence: 99%

“…It has been shown in many species that the dietary cation anion balance (DCAB) influences acid base homeostasis and urine pH [1][2][3][4][5][6][7][8]. DCAB is calculated by adding the weighted amount of acidifying anions and alkalizing cations in the diet [5].…”

Section: Introductionmentioning

confidence: 99%

“…DCAB is calculated by adding the weighted amount of acidifying anions and alkalizing cations in the diet [5]. With the DCAB, the resulting urinary pH can be predicted with species-specific equations [1,[3][4][5][6][7][8][9]. In cats and dogs, modification of urine pH is used in nutritional urolith prevention by altering the solubility of concrement-forming mineral salts [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Strain and Diet on Urinary pH in Laboratory Mice

Böswald

Matzek

Kienzle

et al. 2021

Animals

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Acid base homeostasis and urine pH is influenced by the dietary cation anion balance (DCAB) in many species. Here, a negative DCAB acidifies the urine, while higher DCABs alkalize the urine. The dimension of the DCAB effect can be species-specific, because of differences in urine buffer systems. The aim of the present study was to describe the response of laboratory mice to diets with different DCAB. We used 8-week-old wildtype male mice of the C57Bl/6J inbred strain and CD1 outbred stock. Three groups (n = 15 animals/group) were formed and fed standard diet A for adaptation. For the 7-week feeding trial, mice were either kept on diet A (DCAB −7 mmol/kg dry matter (DM) or switched to diet B (246 mmol/kg DM) or C (−257 mmol/kg DM). Urine pH was measured weekly from a pooled sample per cage. There was a significant difference in the basal urine pH on diet A between C57Bl6/J and CD1 mice. The shift in urine pH was also significantly different between the two groups investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Feeding Trialmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Strain and Diet on Urinary pH in Laboratory Mice

Böswald

Matzek

Kienzle

et al. 2021

Animals

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“…The initial bene t of feeding a low-DCAD diet was reported by Block [2], who observed that treatment with − 172.3 (mmol/kg DM) DCAD could prevent hypocalcemia compared to a control DCAD of + 448.6 (mmol/kg DM). The DCAD level has been an important parameter in the process of formulating diets in recent years [3][4][5][6][7]. Studies have shown that diets with a lower DCAD could enhance the health and extend the economic life of transition mammary animals [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Reducing dietary cation–anion difference seldom affects rumen fermentation, cellulolytic bacteria populations, and microbiota in goats

Yang

Tian

Jian

et al. 2020

Preprint

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Background: Dietary cation–anion difference (DCAD) has been receiving increased attention in recent years; however, information on the rumen fermentation, cellulolytic bacteria populations, and microbiota of goats fed a low-DCAD diet is less. This study aimed to evaluate the feasibility of feeding a low-DCAD diet for goats with emphasis on rumen fermentation parameters, cellulolytic bacteria populations and microbiota. Growth performance, urine pH, and plasma metabolites were also analyzed as well. Materials and method: Eighteen goats were randomly allocated to 3 treatments with six replicates of each treatment and 1 goat per replicate. Animals were fed diets with varying DCAD levels at +338 (High DCAD; HD), +152 (Control; CON), and −181 (Low DCAD; LD). This study includes 15-d experimental period and 30-d adaption period. Results: The DCAD level did not affect the rumen fermentation parameters including pH, buffering capability, acetic acid, propionic acid, butyric acid, total volatile fatty acids, and ratio of acetic acid/propionic acid (P > 0.05). The 4 main ruminal cellulolytic bacteria populations including Fibrobacter succinogenes, Ruminococcus flavefaciens, Butyrivibrio fibrisolvens and Ruminococcus albus did not differ from DCAD treatments (P > 0.05). The DCAD levels did not affect bacterial richness and diversity indicated by the indices Chao, Ace and Simpson and Shannon, respectively (P > 0.05). Both weighted UniFrac and unweighted UniFrac showed no difference in the composition of rumen microbiota for CON, HD and LD (P > 0.05). At the phylum level, Bacteroidetes was the predominant phylum followed by Firmicutes, Synergistetes, Proteobacteria, Spirochaetae, and Tenericutes, and they showed no difference (P > 0.05) in relative abundances except for Firmicutes, which was higher in HD and LD compared to CON (P < 0.05). At the genus level, relative abundance of 11 genera were not affected by DCAD treatments (P > 0.05). Level of DCAD had no effect (P > 0.05) on growth performance including dry matter intake, average net gain, average daily gain, and feed conversion ratio; and nutrients digestibility of crude protein, neutral detergent fiber, acid detergent fiber, and organic matter (P > 0.05). Urine pH in LD was lower than HD and CON (P < 0.05). LD resulted in higher plasma calcium than HD and CON (P < 0.05) but not for other plasma metabolites (P > 0.05). Conclusion: We conclude that, with regard to the great importance of rumen fermentation, these results suggest that reducing DCAD is unharmful for rumen status and provide the feasibility of feeding a low-DCAD to goats.

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Digestibility of crude nutrients and minerals in C57Bl/6J and CD1 mice fed a pelleted lab rodent diet

Böswald,

Matzek,

Popper

2024

Sci Rep

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In laboratory animals, there is a scarcity of digestibility data under non-experimental conditions. Such data is important as basis to generate nutrient requirements, which contributes to the refinement of husbandry conditions. Digestibility trials can also help to identify patterns of absorption and potential factors that influence the digestibility. Thus, a digestibility trial with a pelleted diet used as standard feed in laboratory mice was conducted. To identify potential differences between genetic lines, inbred C57Bl/6 J and outbred CD1 mice (n = 18 each, male, 8 weeks-old, housed in groups of three) were used. For seven days, the feed intake was recorded and the total faeces per cage collected. Energy, crude nutrient and mineral content of diet and faecal samples were analyzed to calculate the apparent digestibility (aD). Apparent dry matter and energy digestibility did not differ between both lines investigated. The C57Bl/6 J mice had significantly higher aD of magnesium and potassium and a trend towards a lower aD of sodium than the mice of the CD1 outbred stock. Lucas-tests were performed to calculate the mean true digestibility of the nutrients and revealed a uniformity of the linear regression over data from both common laboratory mouse lines. The mean true digestibility of crude nutrients was > 90%, except for fibre, that of the minerals ranged between 66 and 97%.

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Effect of cation–anion balance in feed on urine pH in rabbits in comparison with other species

Cited by 5 publications

References 40 publications

Influence of Strain and Diet on Urinary pH in Laboratory Mice

Influence of Strain and Diet on Urinary pH in Laboratory Mice

Reducing dietary cation–anion difference seldom affects rumen fermentation, cellulolytic bacteria populations, and microbiota in goats

Digestibility of crude nutrients and minerals in C57Bl/6J and CD1 mice fed a pelleted lab rodent diet

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