Effect of carvacrol on hepatic marker enzymes and antioxidant status in <scp>d</scp>‐galactosamine‐induced hepatotoxicity in rats

Balakrishnan, Arun; Al‐Numair, Khalid S.; Veeramani, Chinnadurai; Pugalendi, Kodukkur Viswanathan

doi:10.1111/j.1472-8206.2009.00721.x

Cited by 77 publications

(73 citation statements)

References 43 publications

(56 reference statements)

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“…In diabetic animals, the lesions of the pancreas and liver are decreased after CAR exposure (Akkol et al 2009;Ezhumalai et al 2014). And CAR is shown to be the effective antioxidant in protecting the D-galactosamine-induced lipid peroxidation of the erythrocytes, liver and kidney membranes (Aristatile et al 2009). CAR also depicts a preventive effect on leukocyte migration (in vivo and in vitro) and shows anti-inflammatory effects in respirator system.…”

Section: Discussionmentioning

confidence: 99%

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

et al. 2015

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Acute pancreatitis (AP) is considered as major problem around the world and the incidence of AP is increasing. Carvacrol (CAR), a monoterpenic phenol, has good antioxidant activity. This in vivo study was designed to evaluate whether CAR provide protection against AP that developed by pancreas injury. The rats were randomised into groups to receive (I) no therapy; (II) 50 lg/kg cerulein at 1 h intervals by four intraperitonally (i.p.) injections; (III) 50, 100 and 200 mg/kg CAR by one i.p. injection; and (IV) cerulein plus CAR after 2 h of cerulein administration. 12 h later, serum samples were obtained to assess pancreatic function, the lipase and amylase values. The oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as malondialdehyde (MDA) and changes in main tissue antioxidant enzyme levels including SOD, CAT and GSH-PX. Histopathological examination was performed using scoring systems. Additionally, oxidative DNA damage was determined by measuring the increases of 8-hydroxy-deoxyguanosine (8-OH-dG) formations. We found that the increasing doses of CAR decreased AP-induced MDA and 8-OH-dG levels. Moreover, the pancreas antioxidant enzyme activities were higher than that of the rats in the AP group when compared to the AP plus CAR group. In the treatment groups, the lipase and amylase were reduced. Besides, histopathological findings in the pancreatic tissue were alleviated (p \ 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to pancreas.

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Section: Discussionmentioning

confidence: 99%

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

et al. 2015

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“…phase I enzymes, such as 7-ethoxycoumarin-O-deethylase (ECOD) and phase II enzymes, such as GST and quinone reductase (QR). Study of Aristatile et al [82] was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on d-galactosamine (D-GalN) -induced hepatotoxicity and oxidative damage in male albino Wistar rats. D-GalN hepatotoxic rats exhibited elevation in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase and lipidperoxidative markers such as thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides.…”

Section: Mutagenicity Anti-mutagenicity and Dna-protective Effectsmentioning

confidence: 99%

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Slameñová¹,

Horváthová²

2013

neo

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Flowers, berries, leaves, barks and roots of different plants have been used through the ages as a source of flavor in food and perfume preparations. The volatiles responsible for the flavor of botanicals can be extracted from the plant material as "essential oils" (EOs), called also volatile oils or ethereal oils. The term essential is intended to indicate that the oil is the fragrant essence of the plant from which it is extracted. EOs are constituted by hydrocarbons (monoterpenes and sesquiterpenes) and oxygenated compounds (alcohols, esters, ethers, aldehydes, ketones, lactones, phenols and phenol ethers). Of the numerous groups of naturally occurring compounds examined so far terpenes are known as fragrances and flavoring agents. The data reported in this review including the data obtained in our laboratory show that many of EOs exhibit a range of biological activities inclusive of antioxidative, anti-mutagenic and anti-carcinogenic activities. Most of them belong to phytochemicals with chemopreventive potential. On the other hand some herbal products can cause serious adverse effects. A complex research of toxic, genotoxic, anti-mutagenic and anti-carcinogenic effects of EOs is therefore very important.

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“…The antioxidants that can eliminate toxic side effects of chemotherapy can provide the use of higher and more effective doses of the anticancer drugs (Simone et al 2007). Carvacrol (Car) possesses a wide variety of pharmacological properties such as hepatoprotective (Aristatile et al 2009), antiinflammatory (Hajhashemi et al 2002), antioxidant (Yanishlieva et al 1999), antitumour (Evangelou et al 1997;Ipek et al 2005), antimutagenic (Ipek et al 2005) antimicrobial (Shelef 1983), antibacterial and antiviral activities (Sokmen 2004). Car also inhibits liposome phospholipid peroxidation and has a higher antioxidant (AO) activity than various syntethic antioxidants (Baser 2008).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Çetik

Ayhancı

Şahıntürk

2015

Braz. arch. biol. technol.

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Effect of carvacrol on hepatic marker enzymes and antioxidant status in d‐galactosamine‐induced hepatotoxicity in rats

Cited by 77 publications

References 43 publications

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

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