Effect of carvacrol essential oils on immune response and inflammation-related genes expression in broilers challenged by lipopolysaccharide

Liu, Shu Dong; Song, Minho; Wang, Yun; Lee, J.H.; Kim, H.B.; Cho, J.H.

doi:10.3382/ps/pey575

Cited by 64 publications

(45 citation statements)

References 24 publications

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“…Furthermore, carvacrol application dampened intestinal pro-inflammatory immune responses upon C. jejuni infection as indicated by less abundance of T and B lymphocytes in the mucosa and lamina propria of both, the large and the small intestines and lower concentrations of pro-inflammatory mediators including TNF and IL-6 in the intestinal tract and further, in the MLN draining the infected intestines. These results are supported by recent in vitro studies showing that carvacrol treatment of both, stimulated dendritic cells and macrophages resulted in less distinct TNF and IFN-γ secretion [51], whereas carvacrol could down-regulate lipopolysaccharide (LPS) induced expression of pro-inflammatory cytokines such as TNF and IL-6 in broilers [52].…”

Section: Discussionsupporting

confidence: 61%

Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model

et al. 2020

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Background: The prevalence of human infections with the zoonotic pathogen Campylobacter jejuni is rising worldwide. Therefore, the identification of compounds with potent anti-pathogenic and anti-inflammatory properties for future therapeutic and/or preventive application to combat campylobacteriosis is of importance for global health. Results of recent studies suggested carvacrol (4-isopropyl-2-methylphenol) as potential candidate molecule for the treatment of campylobacteriosis in humans and for the prevention of Campylobacter colonization in farm animals. Results:To address this in a clinical murine infection model of acute campylobacteriosis, secondary abiotic IL-10 −/− mice were subjected to synthetic carvacrol via the drinking water starting 4 days before peroral C. jejuni challenge. Whereas at day 6 post-infection placebo treated mice suffered from acute enterocolitis, mice from the carvacrol cohort not only harbored two log orders of magnitude lower pathogen loads in their intestines, but also displayed significantly reduced disease symptoms. Alleviated campylobacteriosis following carvacrol application was accompanied by less distinct intestinal apoptosis and pro-inflammatory immune responses as well as by higher numbers of proliferating colonic epithelial cells. Remarkably, the inflammation-ameliorating effects of carvacrol treatment were not restricted to the intestinal tract, but could also be observed in extra-intestinal organs such as liver, kidneys and lungs and, strikingly, systemically as indicated by lower IFN-γ, TNF, MCP-1 and IL-6 serum concentrations in carvacrol versus placebo treated mice. Furthermore, carvacrol treatment was associated with less frequent translocation of viable C. jejuni originating from the intestines to extra-intestinal compartments. Conclusion: The lowered C. jejuni loads and alleviated symptoms observed in the here applied clinical murine model for human campylobacteriosis highlight the application of carvacrol as a promising novel option for both, the treatment of campylobacteriosis and hence, for prevention of post-infectious sequelae in humans, and for the reduction of C. jejuni colonization in the intestines of vertebrate lifestock animals.

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Section: Discussionsupporting

confidence: 61%

Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model

et al. 2020

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“…Nevertheless, with reference to our hypothesis, AA may favour lipolysis in the adipose tissue resulting in decreased plasma concentration of cholesterol and may exert an indirect change in lipids profile in plasma and consequently in tissues (Pucci, Chiovato, & Pinchera, 2000). Liu et al (2019) reported that AA activates AMPKα, which in turn upregulates the expression of lipid oxidation genes in the liver leading to decreased fat accumulation. Hepatic toxicity is characterized by a rise in serum ALT and AST activities as liver damage biomarker enzymes.…”

Section: Discussionmentioning

confidence: 74%

“…Satureja khuzistanica, an herbaceous aromatic and medicinal plant belonging to the Lamiaceae family, is potentially a favourite candidate for the same purpose (Khosravinia, 2015(Khosravinia, , 2016. Carvacrol is well known for antioxidant (Lahmar, Akcan, Chekir-Ghedira, & Estévez, 2018), anti-inflammatory (Liu et al, 2019) and immunomodulatory (Alagawany, El-Hack, Farag, Tiwari, & Dhama, 2015;Hashemipour, Kermanshahi, Golian, & Veldkamp, 2013) properties based on the results of the several in vitro and in vivo studies. Carvacrol is well known for antioxidant (Lahmar, Akcan, Chekir-Ghedira, & Estévez, 2018), anti-inflammatory (Liu et al, 2019) and immunomodulatory (Alagawany, El-Hack, Farag, Tiwari, & Dhama, 2015;Hashemipour, Kermanshahi, Golian, & Veldkamp, 2013) properties based on the results of the several in vitro and in vivo studies.…”

Section: Mirderikvandi Et Almentioning

confidence: 99%

“…This medicinal herb contains up to 4.5% essential oils comprising up to 94 per cent of a phenolic monoterpene known as carvacrol, an explicit characteristic which caused to plant be described as a bioreactor of carvacrol by Khosravinia (2016). Carvacrol is well known for antioxidant (Lahmar, Akcan, Chekir-Ghedira, & Estévez, 2018), anti-inflammatory (Liu et al, 2019) and immunomodulatory (Alagawany, El-Hack, Farag, Tiwari, & Dhama, 2015;Hashemipour, Kermanshahi, Golian, & Veldkamp, 2013) properties based on the results of the several in vitro and in vivo studies.…”

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confidence: 99%

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Independent and combined effects of Satureja khuzistanica essential oils and acetic acid on prevalence and intensity of fatty liver syndrome in broiler chickens

Mirderikvandi

Khosravinia

Kavan

2019

Animal Physiology Nutrition

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Two hundred fifty two male Ross 308 broiler chicks were raised to examine the effects of Satureja khuzistanica essential oils (SkEO; 0, 200, 300, 400, 500 and 600 mg/bird/day) administrated via oral gavage and dietary supplementation of acetic acid (AA; 0 or 20 g/kg) in a 6 × 2 factorial fashion using a complete randomized block design with seven replicates of three birds each. In Day 34 of age, liver fat percentage decreased by increasing SkEO levels in a quadratic trend (p < .05). Oral gavag of 200 and 300 mg of SkEO decreased AST activity by 16.67% and 16.94%, respectively, compared with the control birds (p < .05). In Day 38 of age, liver percentage was greater by 0.37% in the birds received 400 mg SkEO than those given 500 mg (p < .05). Liver fat percentage decreased in the birds fed the acidified diet and received 300 and 500 mg SkEO as well as in the birds offered 200 and 400 mg of SkEO and fed non‐acidified diet than those received acidified diet with no SkEO administration (p < .05). Prevalence of score zero for hepatocytic vacuolations and necrosis was 80.00% and 42.42% in the birds receiving 600 mg SkEO respectively. Median for relative frequency of scores for hepatocytic vacuolations and hepatocytic necrosis was lesser in the birds received SkEO by oral gavage compared with that of control birds (p < .05). In conclusion, administration of SkEO via oral gavage reduced liver fat in broiler chicken but no consistent dosage could be verified as the effective dosage for all ages concerned. The acidified diet per se showed no evident effect on liver fat at all ages considered. The SkEO × AA interaction exhibited promising but unreliable effects on liver colour score in market age (42 days).

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“…In addition, dietary EEO linearly increased serum catalase activity although statistical significance was not reached. Dietary EO or their combinations have been known to increase antioxidant markers in naïve chickens or those challenged with lipopolysaccharide [42], Clostridium perfringens [43], Eimeria [26] or Salmonella spp. [44].…”

Section: Discussionmentioning

confidence: 99%

Dietary Encapsulated Essential Oils Improve Production Performance of Coccidiosis Vaccine-challenged Broiler Chickens

Lee¹,

Kim²,

Kim³

et al. 2020

Preprint

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The present study was conducted to evaluate encapsulated essential oils as an alternative anticoccidial in coccidiosis vaccine challenged broiler chickens. A total of 600 day-old male broiler chicks were provided with no-added corn-soybean meal-based control diet or diets that contained either salinomycin or EO at 60 and 120 mg per kg of diet. On day 21, half of the control groups were orally challenged with a coccidiosis vaccine at 25 times higher than the recommended vaccine dose. During 22 to 28 days (i.e., one-week post coccidiosis vaccine challenge), the challenged chickens had decrease (P < 0.05) in body weight gain and feed intake but increase in feed conversion ratio compared with the non-challenged, naïve control chickens. However, dietary EO significantly counteracted (P < 0.05) coccidiosis vaccine-induced depression in body weight gain and feed intake. Increasing dietary EO linearly decreased (P < 0.05) the concentrations of the volatile fatty acids. Dietary SAL and EO affected gut morphology in chickens at 20 days posthatch. Increasing dietary EO linearly (P = 0.073) increased serum catalase activity. Collectively, our study shows that dietary EO increased coccidiosis vaccine-induced growth depression and altered gut physiology in broiler chickens.

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Effect of carvacrol essential oils on immune response and inflammation-related genes expression in broilers challenged by lipopolysaccharide

Cited by 64 publications

References 24 publications

Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model

Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model

Independent and combined effects of Satureja khuzistanica essential oils and acetic acid on prevalence and intensity of fatty liver syndrome in broiler chickens

Dietary Encapsulated Essential Oils Improve Production Performance of Coccidiosis Vaccine-challenged Broiler Chickens

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