Effect of Carnitine on Cutaneous Wound Healing in Immunosuppressed Rats

Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

“…Looking at the hydroxyproline levels in the tissues that had been treated with L-carnitine, it was determined that a dose of 100 mg/kg L-carnitine significantly increases the hydroxyproline in tissues. This result is in agreement with the study that was conducted by Akkus et al [23].…”

“…As the result of this study, L-carnitine was found to have positive effects on wound healing speed and on tensile strength of the wound in rats. Akkus et al [23] also found that, when compared to the control groups, due to the increase in hydroxyproline levels related to carnitine treatment, there was a significant increase in tensile strength of the wounds created on the back of rats that were immunosuppressed through chronic steroid administration.…”

“…In literature, many research studies have investigated the effect of topical insulin administration [18], epidermal growth factor [19], fibroblast growth factor, vitamin E [20,21], selenium [22], and taurine [16] on the healing process of tissue defects that have been created in oral mucosa and on oxidative stress. There are also other research studies that have examined the effects of Lcarnitine on the healing of defects developed on the skin [1,[23][24][25][26]. However, in our survey of the literature to date, there have been no research studies published that have investigated the effects of L-carnitine on the wound healing in oral mucosa.…”

“…The administration of antioxidants is effective in decreasing the levels of reactive oxygen types [23]. Many studies propose that vitamin E and L-carnitine have an antioxidant effect and that they sweep free radicals away [5,6,21,[27][28][29][30].…”

A novel composition for in vitro and in vivo regeneration of skin and connective tissues

“…Carnitine supplementation may help to restore the energy deficiency caused by chronic steroid administration in the wound . l ‐Carnitine is an amino acid derivative found in high‐energy demanding tissues.…”