Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite

Safarzadeh, Marjan; Chee, Chin Fei; Ramesh, S.

doi:10.1016/j.ceramint.2022.03.076

Cited by 14 publications

(11 citation statements)

References 35 publications

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“…Table 2 shows the weight loss of the developed calcium carbonate cements compared with that of the apatitic cement in solution as reported in the literature. 56 As expected, the weight losses of calcium carbonate cements prepared in the present work were superior to those of apatitic materials 56,57 after their immersion in the SBF solution.…”

Section: Resultssupporting

confidence: 80%

On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

et al. 2023

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Section: Resultssupporting

confidence: 80%

On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

et al. 2023

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“…The EDS analysis confirmed the presence of HA in these irregular spherical substances. It is likely that the PBS/HA and MPBS/THA scaffolds were attacked by the SBF solution, which resulted in an ion exchange reaction that promoted HA formation. , …”

Section: Resultsmentioning

confidence: 99%

“…It is likely that the PBS/HA and MPBS/ THA scaffolds were attacked by the SBF solution, which resulted in an ion exchange reaction that promoted HA formation. 42,43 Additionally, after the PBS/HA and MPBS/THA scaffolds were immersed in the SBF solution for 27 days, the Ca/P ratio of the irregular spherical substances on the surfaces decreased with increasing HA and MHA content (Figure 4). This was mainly due to release of some calcium ions (Ca 2+ ) in the HA and THA components of the PBS/HA and MPBS/THA scaffolds, which resulted in an ion exchange reaction with protons (H + ) in the SBF solution, thereby reducing the Ca/P ratio.…”

Section: Analysis Of Calcium and Phosphate Deposits On Scaffold Sampl...mentioning

confidence: 99%

Three-Dimensionally Printed Scaffolds of Crab Shell-Derived Calcium Hydroxide, Beef Bone-Derived Hydroxyapatite, and Poly(butylene succinate) Composites

Wang

2023

ACS Appl. Polym. Mater.

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Recycled beef bones (BBs) and crab shells (CSs) were processed into natural derivatives. Through innovative design, these natural derivatives were then combined with biopolymers to create a type of ecofriendly filament suitable for three-dimensional (3D) printing of scaffolds for bone regeneration. The BBs and CSs were thermally processed to produce BB-derived hydroxyapatite (HA) and CS-derived calcium hydroxide (TCS), respectively. Maleic anhydride-modified poly(butylene succinate) (MPBS), HA, and TCS were combined and fabricated into composite filaments, which were then transformed into scaffolds using 3D printing technology. The structure and antibacterial behavior of the obtained composite scaffolds were studied. Alone, PBS showed no bacterial inhibition. A mixture of HA and TCS (THA) was added to MPBS to form a MPBS/THA composite material, which significantly improved the functional properties of cell proliferation and antibacterial effect. The calcium hydroxide content of TCS was responsible for the antibacterial effect. The MPBS/THA composites were porous and displayed enhanced osteoblast proliferation in vitro. The surfaces of the various PBS/HA and MPBS/THA composites showed elevated levels of calcium and phosphorus compounds when exposed to simulated body fluids. Calcium and phosphate ions were rapidly deposited on PBS/HA and MPBS/THA composite scaffolds in osteoblasts according to the cell mineralization assay. Our findings indicate great potential for PBS/HA and MPBS/THA composite scaffolds in bone tissue engineering applications.

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“…Further, TNC surfaces prepared by pre-calcification are known to exhibit excellent bioactivity in SBF [ 47 ]. The HA crystal structure formed on the surface continued to absorb and grow both calcium and phosphate in SBF [ 48 ]: 10Ca 2+ (aq) + 6PO 4 3− (aq) + 2OH − (aq) ↔ Ca 10 (PO 4 ) 6 (OH) 2(s) . Through these reactions, it was confirmed in Figure 5 C that the TiO 2 peak was reduced in all the GH−TNC groups, and that the crystallization of HA was accelerated.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants

et al. 2022

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The gingerols and shogaols derived from ginger have excellent antibacterial properties against oral bacteria. However, some researchers have noted their dose-dependent potential toxicity. The aim of this study was to enhance the biofunctionality and biocompatibility of the application of ginger to dental titanium screws. To increase the amount of coating of the n-hexane-fractionated ginger on the titanium surface and to control its release, ginger was loaded in different concentrations in a photo-crosslinkable GelMA hydrogel. To improve coating stability of the ginger hydrogel (GH), the wettability of the surface was modified by pre-calcification (TNC), then GH was applied on the surface. As a result, the ginger fraction, with a high content of phenolic compounds, was effective in the inhibition of the growth of S. mutans and P. gingivalis. The GH slowly released the main compounds of ginger and showed excellent antibacterial effects with the concentration. Although bone regeneration was slightly reduced with the ginger-loading concentration due to the increased contents of polyphenolic compounds, it was strongly supplemented through the promotion of osteosis formation by the hydrogel and TNC coating. Finally, we proved the biosafety and superior biofunctionalities the GH−TNC coating on a Ti implant. However, it is recommended to use an appropriate concentration, because an excessive concentration of ginger may affect the improved biocompatibility in clinical applications.

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Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite

Cited by 14 publications

References 35 publications

On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

Three-Dimensionally Printed Scaffolds of Crab Shell-Derived Calcium Hydroxide, Beef Bone-Derived Hydroxyapatite, and Poly(butylene succinate) Composites

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants

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