Effect of carbon tetrachloride on gonadal physiology in male rats

Kalla, N.R.; Bansal, M. P.

doi:10.1159/000144399

Cited by 15 publications

(11 citation statements)

References 2 publications

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“…Marked histopathological damages such as necrosis, degeneration, desquamation, disorganisation, reduction in germinal cells, spermatogenic arrest, multinuclear syncytial cell formation and significant decreases in diameters of ST, GCLT and Johnsen's testicular score were determined in CCl 4 group as compared to the control group in this study. Similar findings including exfoliation of the germinal epithelium, depletion and degeneration of germ cells, shrinkage of the tubules, vacuolisation of germinal epithelium and meiotic arrest have been reported following long‐term (from 20 days to 16 weeks) CCl 4 administration in rats (Kalla & Bansal, ; Horn et al ., ; Khan & Ahmed, ; Khan, ; Yüce et al ., ). Apoptosis is known to be a programmed cell death for controlling the spermatogonial population within the testis.…”

Section: Discussionsupporting

confidence: 79%

“…In addition, as the testis, prostate (Jiang et al ., ), epididymis (Hudson et al ., ) and germ cells (Liu et al ., ) contain CYP isozymes, it is possible that CCl 4 causes oxidative damage in lipids of these tissues and cells (Abraham et al ., ). Acute or chronic CCl 4 administration has been reported to cause morphological, structural and functional damages in reproductive system through oxidative toxicity in male laboratory animals (Kalla & Bansal, ; Horn et al ., ; Manjrekar et al ., ; Khan & Ahmed, ; Abdou et al ., ; Khan, ; Yüce et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin attenuates carbon tetrachloride-induced testicular damage in rats

et al. 2013

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This study was conducted to investigate the effect of quercetin on carbon tetrachloride (CCl4 )-induced sperm damages, testicular apoptosis and oxidative stress in male rats. Group 1 served as control, group 2 was treated with only quercetin, group 3 was treated with only CCl4 and group 4 received CCl4 + quercetin. All administrations were performed by gavage and maintained for 10 weeks. CCl4 administration caused significant decreases in absolute and relative reproductive organ weights, sperm motility, concentration and testicular glutathione peroxidase (GSH-Px) and catalase (CAT) activities, and significant increases in lipid peroxidation (LPO) level, abnormal sperm rate and testicular apoptotic cell index, along with some histopathological damages when compared to the control group. However, administration of CCl4 together with quercetin provided statistically significant improvements in LPO level, abnormal sperm rate, the degree of histopathological lesions and testicular apoptotic cell index when compared to only CCl4 group. In addition, improvements observed in absolute and relative weights of reproductive organs, sperm motility and concentration, and testicular GSH-Px and CAT activities in group 4 were statistically insignificant when compared to only CCl4 group. In conclusion, quercetin has antiperoxidative effect, and its oral administration attenuates the CCl4 -induced some damages in male reproductive organs and cells by decreasing the LPO.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Quercetin attenuates carbon tetrachloride-induced testicular damage in rats

et al. 2013

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“…However, short-term administration (10-15 days) of CCl 4 has no significant adverse effect on testicular structure (Castilla-Cortazar et al, 2004;Kalla and Bansal, 1975), but it alters hematotesticular barrier (Castilla-Cortazar et al, 2004). Similarly, prominent histopathological damages such as necrosis, degeneration, desquamation, disorganization, reduction in germinal cells, spermatogenic arrest, and significant decreases in diameters of ST, GCLT, and Johnsen's testicular score were determined in CCl 4 group as compared to the control group in this study.…”

Section: Discussionmentioning

confidence: 71%

Ameliorating effect of pomegranate juice consumption on carbon tetrachloride-induced sperm damages, lipid peroxidation, and testicular apoptosis

et al. 2013

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The aim of this study was to investigate whether pomegranate juice (PJ) consumption has an ameliorating effect on carbon tetrachloride (CCl4)-induced sperm damages and testicular apoptosis associated with the oxidative stress in male rats. The study comprised of four groups (groups 1-4). Group 1 received olive oil + distilled water daily; group 2 was treated with 5 ml/kg PJ + olive oil daily; group 3 was treated with 0.25 ml/kg CCl4 dissolved in olive oil, weekly + distilled water daily; and group 4 received weekly CCl4 + daily PJ. All administrations were performed by gavage and maintained for 10 weeks. CCl4 administration caused significant decreases in body and reproductive organ weights, sperm motility, concentration and testicular catalase activity, significant increases in malondialdehyde (MDA) level, and abnormal sperm rate and apoptotic index along with some histopathological damages when compared with the control group. However, significant ameliorations were observed in absolute weights of testis and epididymis, all sperm quality parameters, MDA level, apoptotic index, and testicular histopathological structure following the administration of CCl4 together with PJ when compared with group given CCl4 only. In conclusion, PJ consumption ameliorates the CCl4-induced damages in male reproductive organs and cells by decreasing the lipid peroxidation.

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“…It has been reported that long‐term CCl 4 administration (from 20 days to 16 weeks) leads to severe damage to the spermatogenic cycle such as exfoliation of the germinal epithelium, depletion and degeneration of germ cells, shrinkage of the tubules, vacuolisation of germinal epithelium and meiotic arrest (Kalla & Bansal, ; Horn et al ., ; Khan & Ahmed, ; Khan, ). However, short‐term administration (10–15 days) of CCl 4 has no marked adverse effect on testicular structure (Kalla & Bansal, ; Castilla‐Cortazar et al ., ), but it alters hematotesticular barrier (Castilla‐Cortazar et al ., ). Similarly, prominent histopathological damages such as necrosis, degeneration, desquamation, disorganisation, reduction in germinal cells, spermatogenic arrest and marked decreases in diameters of ST, GCLT and Johnsen's testicular score were determined in CCl 4 group only as compared to the control group herein.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the existence of some CYP genes in the male reproductive organs, CCl 4 causes usually oxidative damage to the lipids and proteins of the reproductive tissues (Abraham et al ., ). It has been reported that acute or chronic CCl 4 administration to adult male rats causes increments in testicular tissue LPO level (Abraham et al ., ; Fadhel & Amran, ; Khan & Ahmed, ; Soliman & Fahmy, ; Khan, ), sperm abnormalities and testicular tissue DNA fragmentation (Abdou et al ., ; Khan, ); reductions in weights of body and testes (Castilla‐Cortazar et al ., ; Manjrekar et al ., ; Khan & Ahmed, ), sperm count and motility (Khan, ) and antioxidant enzymes (Khan & Ahmed, ; Soliman & Fahmy, ; Khan, ); degeneration in testicular histologic structure (Kalla & Bansal, ; Castilla‐Cortazar et al ., ; Horn et al ., ; Khan & Ahmed, ); and disturbances in steroid and gonadotropin hormones (Castilla‐Cortazar et al ., ; Khan & Ahmed, ; Khan, ).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system

et al. 2013

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In this study, it was aimed to investigate the likelihood of detrimental effects of carbon tetrachloride (CCl4 ) on male reproductive system through oxidative stress mechanism and also protective effects of cinnamon bark oil (CBO). For this purpose, 28 healthy male Wistar rats were divided into four groups, seven rats in each. Group 1 received only olive oil daily; group 2 was treated with 100 mg kg(-1) CBO daily; group 3 was treated with only 0.25 ml kg(-1) CCl4 weekly; and group 4 received weekly CCl4 + daily CBO. All administrations were made by intragastric catheter and maintained for 10 weeks. Body and reproductive organ weights, sperm characteristics, testicular oxidative stress markers and testicular apoptosis were examined. CCl4 administration caused significant decreases in body and reproductive organ weights, testicular catalase (CAT) activity, sperm motility and concentration, and significant increases in lipid peroxidation (LPO) level, abnormal sperm rate and apoptotic index along with some histopathological damages compared with the control group. However, significant improvements were observed in absolute weights of testis and epididymis, all sperm quality parameters, LPO level, apoptotic index and testicular histopathological structure following the administration of CCl4 together with CBO when compared to group given CCl4 only. The findings of this study clearly suggest that CBO has protective effect against damages in male reproductive organs and cells induced by CCl4 .

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Effect of carbon tetrachloride on gonadal physiology in male rats

Cited by 15 publications

References 2 publications

Quercetin attenuates carbon tetrachloride-induced testicular damage in rats

Quercetin attenuates carbon tetrachloride-induced testicular damage in rats

Ameliorating effect of pomegranate juice consumption on carbon tetrachloride-induced sperm damages, lipid peroxidation, and testicular apoptosis

Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system

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