Effect of Carbohydrate-Enriched Drink Compared to Fasting on Hemodynamics in Healthy Volunteers. A Randomized Trial

Abstract

Fasting prior to surgery can cause dehydration and alter hemodynamics. This study aimed to determine the impact of a carbohydrate-enriched drink (NutriciaTM Pre-op®) on selected hemodynamical parameters, measured in a non-invasive manner. We enrolled 100 healthy volunteers and measured their weight, height, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), thoracic fluid content (TFC), thoracic fluid index (TFCI), stroke volume (SV), stroke volume variation (SVV), stroke index (SI), cardiac output (CO), cardiac index (CI), heather index (HI), systolic time ration (STR), systemic time ratio index (STRI), systemic vascular resistance (SVR), and systemic vascular resistance index (SVRI) by a Niccomo™ device, implementing the impedance cardiography (ICG) method. Measurements were performed at the beginning of the study, and after 10 h and 12 h. We randomly allocated participants to the control group and the pre-op group. The pre-op group received 400 mL of Nutricia™ preOp®, as suggested in the ERAS guidelines, within 10 h of the study. Student’s t-test or the Mann–Whitney U test were used to compare the two groups, and p < 0.05 was considered significant. We did not observe any changes in hemodynamical parameters, blood pressure, and heart rate between the groups. We have proven that carbohydrate-enriched drink administration did not have a significant impact on the hemodynamical parameters of healthy volunteers.

Perioperative carbohydrate loading in patients undergoing one-day surgery. A systematic review of randomized controlled trials

“…Usually artificially flavoured water was used for this purpose. Given the fact that the carbohydrate-rich drink affects neither hydration [24] nor hemodynamic parameters [25], nor causes significant metabolic changes, any beneficial findings could be associated with a psychosomatic effect. However carbohydrates have been proven not to alter mood in any significant way in healthy adults [26].…”

Increased thoracic fluid content is associated with higher risk for pneumonia in patients undergoing maintenance hemodialysis

“…With the development of new hardware and computational algorithms, impedance cardiography (ICG) is becoming more accurate and may provide a noninvasive alternative to hemodynamic monitoring [ 5 , 6 ]. Among the parameters monitored by ICG, thoracic fluid content (TFC) is an indicator for the assessment of changes in chest fluid volume [ 7 ].…”