Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis

Farooq, Assim Oday; Mohammed, Nadia H.

doi:10.32947/ajps.v22i1.825

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The processes of inflammation and edema were also examined by measuring joint circumference using the following equation (4,25) :…”

Section: Ankle Joint Circumferencementioning

confidence: 99%

“…Annual incidence and prevalence rates for RA are 3 cases per 10,000 people and 1%, respectively, on a global scale (3) . In Iraq, it was observed an increase in RA incidence from 1.60 % in 2001 to 3.02% in 2011 (4) . The dysregulated synthesis of citrullinated proteins in RA joints is referred to as RA citrulline which is one of the crucial steps in the autoimmune response (5) .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Docetaxel on Matrix Metalloproteinase 1 Expression in Freund’s Adjuvant Induced Arthritis

Alghulami,

Ghaith A. Jasim,

Suzan Yousif Jasim

2024

IJPS

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Rheumatoid arthritis is an autoimmune disorder that affects the synovial joints. It lead to inflammatory changes occur in synovial tissue, cartilage, bone, and, less frequently, extra-articular structures. Docetaxel, is an anti-neoplastic drug. Methotrexate is a treatment for early-stage rheumatoid arthritis but have 30% failure in treatment within the first year due to resistance or side effects. Matrix metalloproteinase 1 is the proteinase primarily in charge of the irreversible degradation of cartilage, bone, and tendons in the joints, which are induced by cytokines. This study aims to evaluate the effects of docetaxel and methotrexate on Matrix metalloproteinase 1 in the structure of the induced arthritis joints. Methods: To induce the disease, complete Freund's adjuvant is injected subcutaneously into rats. From the 40 male Wister rats, five groups of eight were formed. The control group is composed of non-diseased rats. The second group is induced by complete Freund's adjuvant and 0.5 ml of normal saline was administered intraperitoneally to both the control and induction groups. After being induced by complete Freund's adjuvant, the third group is administered 1 mg/kg/ on alternate day of Docetaxel based on a preliminary experiment. The fourth group is induced and given 1 mg/kg/week of Methotrexate intraperitoneally. The fifth group receives a half dose of Methotrexate and Docetaxel simultaneously. Serum level of Anti Cyclical citrullinated Peptide Antibody, tissue homogenate level of tumor necrosis factor-alpha, knee joint circumference and Immunohistochemical of Matrix metalloproteinase 1 measurements were applied. Results: Significant decreased in the Serum level of Anti-Cyclic citrullinated Peptide Antibody, tissue homogenate level of tumor necrosis factor-alpha & Knee joint circumference in the Docetaxel group. significant lowering in the expression of Matrix metalloproteinase 1 immunoreactivities in Docetaxel and Methotrexate groups with almost absent spots of positive reaction with the matrix of synovial tissue, hyaline cartilage & articular surface. Conclusion: This study showed that Docetaxel may have anti-arthritic effect through their significant lowering expression of Matrix metalloproteinase 1 immunoreactivities.

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“…The processes of inflammation and edema were also examined by measuring joint circumference using the following equation (4,25) :…”

Section: Ankle Joint Circumferencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Docetaxel on Matrix Metalloproteinase 1 Expression in Freund’s Adjuvant Induced Arthritis

Alghulami,

Ghaith A. Jasim,

Suzan Yousif Jasim

2024

IJPS

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“…An increased risk of cardiovascular disease and a shorter life expectancy is also linked to RA [3] . It has a global yearly incidence and prevalence rate of 3 cases per 10,000 persons and 1%, respectively [4] .The prevalence of RA in Babylon is about 3% in Iraq [5] . Citrullination is a post-translational modification performed by the calciumdependent peptidyl-arginine-deiminase (PAD), which converts positively charged arginine to neutral citrulline [6] .…”

Section: Introductionmentioning

confidence: 99%

Histopathological evaluation of docetaxel effects in treatment of rheumatoid arthritis induced in rat model

Omar Mustafa Alghulami,

Ghaith A. Jasim,

Suzan Yousif Jasim**

2023

AJPS

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Rheumatoid arthritis is an immune-mediated condition that affects synovial joints. Synovial tissue, cartilage, bone, and less frequently extra-articular structures which in turn experience inflammatory changes. Paclitaxel's semi-synthetic equivalent, docetaxel, is an anti-neoplastic drug. Methotrexate is a treatment for early RA and may have a mildly negative impact on peptidyl arginine deiminase type 4 fluorescence test. However, 30% of patients fail to complete treatment within the first year due to resistance or side effects. The synovial membrane of Rheumatoid arthritis patient infiltrated with macrophages and neutrophils that express peptidyl arginine deiminase type 4 which their effect in rheumatoid arthritis pathogenesis lies in the generation of citrullinated neoepitopes that are Anti cyclic citrullinated peptide antibodies-targeted. The purpose of this study: was to assess the anti-inflammatory effects of docetaxel and methotrexate on the joint structure. Methods: Five groups of eight rats were formed from the 40 male Wister rats. Complete Freund’s adjuvant was injected subcutaneously into rats to induce the disease. The first group is control group which was the only group consists of (healthy untreated) rats. Second group was received complete Freund’s adjuvant. 0.5ml of ordinary saline was intraperitoneally administered to both the control and induction groups. Based on a preliminary experiment, the third group was given intraperitoneally 1 mg/kg/on alternative day docetaxel. The fourth group was given intraperitoneally 1 mg/kg/week of Methotrexate. Fifth group was given a half dose of both Methotrexate and docetaxel concurrently. Arthritis index was measured and Knee joint was histopathological examined. Results: significant Arthritis Index decrease in docetaxel group (p≤0.05). Significant lowering Histometric scoring (p≤0.05) in docetaxel, and Methotrexate group (cellular hyperplasia, formation of granulation tissue, infiltration of leukocytes, destroying of cartilage and intensity of erosion & Articular cartilage thickness) level in rats induced arthritis. Conclusion: This study showed that docetaxel may have anti-arthritic effects through their significant lowering Histometric scoring(p≤0.05).

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Evaluating the docetaxel effect in an animal model of polyarthritis

Alghulami,

Jasim,

Jasim

2024

Inflammopharmacol

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Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis

Cited by 3 publications

References 17 publications

Effect of Docetaxel on Matrix Metalloproteinase 1 Expression in Freund’s Adjuvant Induced Arthritis

Effect of Docetaxel on Matrix Metalloproteinase 1 Expression in Freund’s Adjuvant Induced Arthritis

Histopathological evaluation of docetaxel effects in treatment of rheumatoid arthritis induced in rat model

Evaluating the docetaxel effect in an animal model of polyarthritis

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