Effect of Captopril on Pulmonary Artery Pressure Following Corrective Surgery for Tetralogy of Fallot

Abstract

Systolic PAP is elevated following the complete surgical repair of TOF. Increased circulating ET-1 may be responsible for the elevation of PAP. Captopril treatment prevents postsurgical increases in systolic PAP and circulating ET-1.

Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease

“…Echocardiography was conducted as previously described (14). Imaging was performed using a HP 5500 system (Koninklijke Philips Electronics N.V.; Eindhoven, The Netherlands).…”

Prognostic Values of Serum Tenascin-C in Patients with Ischaemic Heart Disease and Heart Failure

“…Echocardiography was conducted as previously described [15]. Imaging was performed using a HP 5500 system.…”

Effect of Prostaglandin E1on Pulmonary Arterial Hypertension Following Corrective Surgery for Congenital Heart Disease

“…All our patients had significant preoperational PAH and ventricular dysfunction before the surgery due to late presentation, a situation which is common in this inland Chinese community. 14 Even with preoperational pharmacological management of PAH and subsequent surgical correction of congenital cardiac defect, residual PAH persisted in all patients. The residual PAH may be due to a number of reasons, such as vasoconstriction, proliferative and obstructive remodeling of the pulmonary vessel wall, inflammation, or thrombosis.…”

“…Captopril (0.3-0.5 mg/kg/d) was the drug of choice in our department because of its low cost and proven effect on pulmonary hypertension. 14 In the PGE 1 group, intravenous infusion of PGE 1 was immediately commenced in addition to captopril and loop diuretics. In the first 3 months following surgery, PGE 1 was intravenously administered daily (200 mg/d, continuous infusion over 10-12 hours) for 10 consecutive days each month.…”