Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease

Abstract

The aim of this study was to evaluate the correlation between levels of serum high-mobility group box-1 (HMGB1) and high-sensitivity C-reactive protein (hs-CRP) and cardiac troponin I in patients with coronary artery disease. The levels of serum HMGB1, hs-CRP and cardiac troponin I were measured in 98 patients with coronary artery disease and in 30 healthy subjects. The correlation between serum HMGB1 levels and hs-CRP and cardiac troponin I levels was analyzed. Serum HMGB1 levels in patients with coronary artery disease were higher compared with those in healthy volunteers (63.5±15.29 vs. 21.98±4.33 μg/l; P<0.01). Serum HMGB1 levels in patients with acute myocardial infarction were higher compared with those in patients with unstable and stable angina pectoris (77.53±6.86 vs. 63.67±8.6 and 44.39±9.01 μg/l, respectively; both P<0.01). The levels of HMGB1 were positively correlated with hs-CRP and cardiac troponin I levels (r=0.657 and 0.554, respectively; both P<0.01) in patients with coronary artery disease. In conclusion, serum HMGB1 levels were elevated in patients with coronary artery disease, particularly in those with acute myocardial infarction. The levels of HMGB1 were correlated with the levels of hs-CRP and cardiac troponin I.

The Role of Inflammation in Myocardial Infarction

“…Specific research on the cardiovascular system is still inconclusive. An interesting finding was that levels of HMGB1 in serum of MI patients are correlated with CRP and Troponin I levels [313]. Furthermore, Xu et al showed that HMGB1 plays a major role in I/R injury by working via TNF-α and the JNK signaling pathway, implying that the blockade of HMGB1 could yield cardioprotective effects [314].…”

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

“…12,32) Previous studies have shown that HMGB1 functions as a pro-inflammatory cytokine in certain cardiovascular diseases, and it was related to the severity of coronary artery disease. 33,34) Yao, et al demonstrated that myocardial expression of HMGB1 significantly increased in rats with acute MI. 35) High serum levels of HMGB1 may cause cardiac inflammation and left ventricular dysfunction after MI.…”

Protection of intravenous HMGB1 on myocardial ischemia reperfusion injury

“…The first 40 peptide segments of B-box can induce the production of TNF-α and IL-6 [4]. As a pro-inflammation cytokine, HMGB1 takes an important role in many cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injuries, heart failure and myocardial infarction [5][6][7][8][9]. Recently, several studies showed that exogenous administration of HMGB1 after myocardial infarction or acute global I/R leads to the recovery of left ventricular function through the regeneration of cardiomyocytes.…”