Effect Of Captopril On Paracetamol Induced Nephrotoxicity In Rats :, Histological Study

The Impact of Black Seeds and Sidr Honey on paracetamol Induced Nephropathy in Adult Male Albino Rats, a Histological, Immunohistochemical & Ultrastructural study

“…In H&E stained sections of Paracetamol injected group (GII), obvious distortion in the structure of the kidney tissue was observed in renal corpuscles as well as proximal convoluted tubules which is in agreement with Al-Shaikh et al 36 &Pathan et al 37 That was explained by that in high dose of paracetamol the reactive oxidative metabolite of paracetamol is accumulated which is removed by glutathione leading to depletion of both cytoplasmic and mitochondrial glutathione and accumulation of free radicals, lipid peroxidation, malondialdehyde elevation and consequently nephrotoxicity. 38,39 In the present study, renal cortex of (GII) revealed dilated congested blood vessels, eosinophilic exudate and mononuclear cellular infiltrations in between the renal corpuscles and tubules, similar results were obtained by Afroz et al 40 & Lim et al 41 In Hematoxylin and Eosin stained sections of GIII (protective group) showed nearly normal histological structure of both Malpighian renal corpuscle and proximal convoluted tubules compared with the control one.…”

“…Which is in accordance to Mousavi et al 20 &Abdallah et al 21 Al-Shaikh et al 36 explained the main intracellular mechanisms that lead to apoptosis is reactive oxygen species (ROS) and peroxy-nitrite formation, triggering the release of intramembranous proteins, chromatin condensation and DNA fragmentation through formation of pores in the outer mitochondrial membrane are the causative mechanisms for mitochondrial dysfunction, decreased membrane permeability and membrane potential with decreased production of energy.…”