Effect of Captopril on Doxorubicin-Induced Nephrotoxicity in Normal Rats

Mansour, Mahmoud A.; El‐Kashef, Hassan A.; Al‐Shabanah, Othman A.

doi:10.1006/phrs.1998.0432

Cited by 46 publications

(36 citation statements)

References 21 publications

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“…Thus, moderate changes in GFR may not be detected by serum Cr levels or BUN. In this study, DOX-injected rats showed low plasma Alb levels, corroborating previous studies reporting hypoalbuminemia in DOX-treated rats [40,41].…”

Section: Discussionsupporting

confidence: 92%

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Oğuz¹,

Beytur²,

Sarihan³

et al. 2016

CIM

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Purpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats.Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined.Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage.Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.

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Section: Discussionsupporting

confidence: 92%

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Oğuz¹,

Beytur²,

Sarihan³

et al. 2016

CIM

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“…Although the relative kidney weight was not changed in the doxorubicin group, yet the serum urea and creatinine levels as well as urea/creatinine ratio were increased (Table 2). Doxorubicin-induced nephrotoxicity was previously reported by many authors in laboratory animals (Badary et al, 2000;Buranakarl et al, 2008;Injac et al, 2008;Mansour et al, 1999). In the present study, the significant elevation in the relative liver weight of rats treated with aloin could be explained due to increased hepatic glycogen synthesis and storage and/or blockage in glycogen utilization.…”

Section: Discussionsupporting

confidence: 70%

Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities

Esmat

Said

Khalil

2014

Pharmaceutical Biology

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Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against different murine and human tumors has been reported. Objective: In the present study, the impact of repeated aloin treatment at its maximum tolerated dose on serum levels of lipid profile, some elements, iron status and kidney function, compared with doxorubicin (a cardiotoxic anthracycline and inhibitor of erythropoiesis), was assessed. Materials and methods: Rats were treated with a single dose of doxorubicin (30 mg/kg body weight, intraperitoneal) or aloin (50 mg/kg body weight, intramuscular) twice weekly over 2 weeks. Results: Acute doxorubicin treatment elevated serum levels of triacylglycerols (59.90%), total cholesterol (42.29%), cholesteryl esters (54.75%), low density lipoprotein-cholesterol (230.16%), very low density lipoprotein-cholesterol (56.42%), urea (287.53%), and creatinine (85.38%), whereas serum high density lipoprotein-cholesterol, sodium, and calcium levels were reduced (44.61, 9.61, and 9.76%, respectively), as compared with controls. In contrast, aloin treatment showed insignificant changes in all the aforementioned parameters. Both doxorubicin and aloin induced erythropoiesis impairment demonstrated by a reduction in blood hemoglobin concentration. While aloin treatment elevated serum iron level (30.28%), doxorubicin treatment reduced serum levels of iron (51.47%) and percent transferrin saturation (55.21%), and in contrast, increased serum total iron binding capacity (34.85%). The chelating affinities of iron-aloin and -doxorubicin complexes, which contain bidentate iron-binding moieties, have been shown in the infrared spectra. Discussion and conclusion: The non-cardiotoxic effect of aloin treatment was due to its non-atherogenic and iron-chelating activities, which might also contribute in part to its anti-proliferative activity.

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“…A graded degeneration in the tubular lining epithelial cells of the nephrons and glomerulus was observed, with cisplatin producing most severe apoptotic and necrotic changes in the nephrons followed by doxorubicin and gentamicin when compared to normal control kidneys. The in vivo nephrotoxicity models using Swiss albino mice showed increase in serum biochemical parameters, namely urea, creatinine and uric acid as reported in the literature 20,29 . The histopathological observations showed an increase in the severity of nephron degeneration with a minimum in gentamicin-treated mice, followed by doxorubicin-treated group and a maximum in cisplatin-treated animals.…”

Section: Discussionsupporting

confidence: 63%

Development of a New <i>in Ovo</i> Model for the Assessment of Nephrotoxicity and its Comparison with an Existing <i>in Vivo</i> Model

Das¹,

Sasmal²,

Mazumder³

et al. 2017

Current Science

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In this study, the chick embryo model has been used as an alternative to the mammalian model for assessing nephrotoxicity. Resemblance of the chick embryo to mammals in having metanephric kidney has prompted us to explore the possibility of using this system for the assessment of kidney toxicity caused mainly by nephrotoxic drugs, namely gentamicin, cisplatin and doxorubicin. Fertilized hens' eggs incubated at 38 2C and 58%-60% relative humidity, were injected with the above-mentioned drugs on embryonic day 11. A significant decrease in the uric acid level of amniotic fluid was shown by embryos of cisplatin and doxorubicin-treated groups when compared to control. Embryos of the gentamicin-treated group showed significant increase in urea concentration. Alterations in uric acid, urea and creatinine levels were found in all groups. Histopathological study showed nephron degeneration. Similar results were found in a mouse model.

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Effect of Captopril on Doxorubicin-Induced Nephrotoxicity in Normal Rats

Cited by 46 publications

References 21 publications

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities

Development of a New <i>in Ovo</i> Model for the Assessment of Nephrotoxicity and its Comparison with an Existing <i>in Vivo</i> Model

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