Effect of Canine Hyperadrenocorticism on Coagulation Parameters

Rose, Lara; Dunn, Marilyn; Bédard, Christian

doi:10.1111/jvim.12005

Cited by 40 publications

(47 citation statements)

References 7 publications

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“…Inclusion criteria included an acute onset of clinical signs (<1 month) associated with increased serum bilirubin concentration and increased serum alanine aminotransferase activity (>3 times the upper limit of normal). Dogs on medications known to affect coagulation (eg, corticosteroids, nonsteroidal anti‐inflammatory drugs, fish oil supplements, vitamin K, antiplatelet drugs, anticoagulants) or with comorbidities associated with coagulation derangements (eg, hyperadrenocorticism, protein‐losing enteropathies, protein‐losing nephropathy, immune‐mediated hemolytic anemia, immune‐mediated thrombocytopenia, infectious enteritis, or extrahepatic neoplasia) were excluded. Additionally, purebred Greyhounds were excluded because of known alterations in clotting kinetics and clot formation …”

Section: Methodsmentioning

confidence: 99%

Thromboelastographic Evaluation of Dogs with Acute Liver Disease

Kelley

Lester

Shaw

et al. 2015

Veterinary Internal Medicne

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Background: Given the liver's pivotal role in hemostasis and fibrinolysis, the coagulopathy accompanying hepatic disease is complex.Hypothesis/Objectives: To prospectively evaluate kaolin-activated thromboelastography (TEG) in dogs with acute liver disease (ALD) and compare with plasma-based coagulation tests.Animals: Twenty-one dogs with a diagnosis of ALD based on recent onset of clinical signs accompanied by increases in serum bilirubin concentration and alanine aminotransferase activity.Methods: Clinical presentation, CBC, serum biochemistry, platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), and TEG analysis were evaluated in 21 dogs with a subset also having fibrinogen, antithrombin (AT) activity, protein C (PC) activity, d-dimers, and von Willebrand's factor (vWF) activity analyzed. A PT >1.5 times the upper limit of normal defined acute liver failure (ALF).Results: Dogs with ALD had mean increases in R, K, LY30, PT, aPTT, and vWF activity, and decreases in angle, maximal amplitude (MA), G, AT activity, and PC activity. The TEG results defined dogs as hypocoagulable (11/21), normocoagulable (8/21), or hypercoagulable (2/21). Increases in LY30 defined 8/21 dogs as hyperfibrinolytic. Hypocoagulable and hyperfibrinolytic dogs had lower fibrinogen and PC activity than dogs without these abnormalities. Overall, ALF dogs had greater increases in K and LY30, and decreases in MA, G, and PC activity than dogs with less severe hepatic impairment. Results for MA and LY30 were positively correlated with serum bilirubin concentration and white blood cell count, and negatively correlated with serum cholesterol concentration.Conclusions and Clinical Importance: ALD dogs have a range of coagulation abnormalities that trend toward hypocoagulability and hyperfibrinolysis as functional impairment occurs.

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Section: Methodsmentioning

confidence: 99%

Thromboelastographic Evaluation of Dogs with Acute Liver Disease

Kelley

Lester

Shaw

et al. 2015

Veterinary Internal Medicne

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“…; Rose et al . ) and hypercoagulability (Klose et al . ) as measured by global viscoelastic testing has been reported but these studies are not specific for platelet function.…”

Section: Clinical Signs Of Thromboembolic Diseasementioning

confidence: 99%

Abnormal platelet activity in dogs and cats – impact and measurement

Gant

McBride

Humm

2020

J of Small Animal Practice

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Abnormal platelet activity can either lead to bleeding tendencies or inappropriate thrombus formation and can occur secondarily to a wide variety of disease processes, with a range of clinical consequences and severity. This article will discuss the pathophysiology of platelet function abnormalities and consider a logical diagnostic approach applicable to veterinary practice. Recent advances in platelet function testing will then be discussed, with regards to detection of platelet dysfunction and tailoring of pharmacological manipulation. Although many of these tests are still confined to research or academic institutions, techniques for indirectly assessing platelet function are starting to become more widely available. Although we still require further research to develop guidelines for the use of these tests in clinical decision‐making, the recent advances in this field are an exciting step forward in being able to detect and manage platelet dysfunction in both primary care and referral practice.

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“…[39][40][41] Thromboembolism as a postoperative event appears to be overrepresented in patients with hyperadrenocorticism or in those treated with corticosteroids, and may be indicative of this exaggerated response. 42,43 Neoplasia has also been identified as a risk factor for thrombosis in veterinary medicine. 44,45 Thrombosis occurs in 20% of human cancer patients and results in decreased survival and an increased risk of recurrent VTE.…”

Section: Comorbidities That Can Exacerbate Surgical Stressmentioning

confidence: 98%