Effect of Calcium Precursors and pH on the Precipitation of Carbonated Hydroxyapatite

Othman, Radzali; Mustafa, Zaleha; Loon, Chong Wee; Noor, Ahmad Fauzi Mohd

doi:10.1016/j.proche.2016.03.050

Cited by 36 publications

(29 citation statements)

References 19 publications

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“…Mechanical properties of the bone are characterized by HAp compositions, its crystalline structure, morphology, particle size and orientation. The crystals are nanometer-sized needle like or rod-like shapes (average length -50 nm, width -25 nm and thicknesses 2-5 nm) scattered in the organic matrix and composed of OH − , Ca 2+ and PO 4 3− groups (closely packed in hexagonal arrangement; space group -P6 3 /m) [3]. Special behavior and bioactivity of biological apatites could vary with HAp dimensions, low crystallinity and presence of carbonate ions in the lattice [3].…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite with required carbonate content has much closer compositional similarity to natural bone minerals. It shows a better bioactivity and is biodegradable [4]. It is widely used as coating for metal prosthesis, orthopedic applications, bone graft, drug and antibiotics carrier in bone-implant interface without showing any cytotoxic effect [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydroxyapatite for bone related applications derived from sea shell waste by simpleprecipitation method

Kumar

Dhanaraj

Vimalathithan³

et al. 2020

Journal of Asian Ceramic Societies

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The nano-hydroxyapatite (NHAp), NHAp/PEG and NHAp/PVP have been derived from Clam shell by precipitation method. The presence of characteristic FTIR peaks and XRD planes indicates the formation of NHAp. Surface morphology of NHAp, NHAp/PEG and NHAp/PVP appeared to be flake, majorly hexagonal and rod clusters like structure, respectively. Sizes of the NHAp are in nanometer scale and size of NHAp/PVP is the lowest. The poor crystalline nature and high carbonate content presence in NHAp/PVP are assessed through crystallinity index, C/P ratio and CHNS analysis. EDX analysis shows the presence of HAp composition in NHAp. The calculated structural parameters expose that the NHAp/PVP shows favorable mechanical property. Good antibacterial activity is observed in NHAp/PVP against two bacteria strains. Hemolysis study also indicates that NHAp/PVP is non-hemolytic. Formation of complete apatite is found when NHAp/PVP immersed in SBF for 14 days. Thus, the NHAp/PVP derived from Clam shell may be useful for bone-related applications. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite for bone related applications derived from sea shell waste by simpleprecipitation method

Kumar

Dhanaraj

Vimalathithan³

et al. 2020

Journal of Asian Ceramic Societies

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“…2(b), (c) and (d) show the SEM micrograph of local hydroxyapatite sintered at 600, 800 and 1000 C. The SEM micrograph shows the agglomeration of particle increases with sintering temperature, as also founded by others [6,9]. Different crystal phases and particle morphology affected the properties of hydroxyapatite.…”

Section: Resultsmentioning

confidence: 90%

“…The mechanical properties of hydroxyapatite may investigated through the tensile test to have Young's modulus, bending strength, fracture toughness number [4], micro hardness and compression [2,5]. An addition of polymer can be used to increase the mechanical and thermal properties of HA [6]. An investigation on the effect of process parameters on the properties of hydroxiapatite made from limestone is still necessary [7].…”

Section: Introductionmentioning

confidence: 99%

The effect of sintering parameter on the properties of hydroxyapatite from local limestone for bone implant application

Sukmana

Hendriyanto

Savetlana

et al. 2018

AIP Conference Proceedings

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Rebound Hammer Test result of old repaired masonry wall using premixed mortar additive in tidal flooding prone area AIP Conference Proceedings 1977, 040012 (2018 Abstract. The damage of bone tissue may cause malfunction of human load-bearing system. To date, hydroxyapatite (HA) is one of the most potential materials to repair bone damages and to restore the load-bearing function. It has been produced from both synthetic chemical and natural resources, including limestone. In this paper, the properties of hydroxyapatite made of CaCO 3 from limestone was investigated in a function of sintering time, i.e., 2, 3 and 4 hours, and temperature, i.e., 600, 800 and 1000 C. The preparation of HA included crushing, meshing, grinding and sintering. HA powder was then characterized using X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS). The hardness of compacted hydroxyapatite powder was also characterized using microVickers testing machine. SEM micrograph shows the agglomeration of particle increase in line with sintering temperature. The highest hardness was obtained for hydroxiapatite sample sintered at the highest temperature and for the longest time, while EDS result indicates the highest ratio of calcium and phosphor was 2.33. The percentage of calcium in the observed local HA decreased as the sintering time increased. A comparison of XRD result between the commercially imported and the local HA powder produced in this study shows a similarity pattern, which indicates the potential replacement of the imported HA by our local limestone resources.

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“…ICa increase followed a similar trend with ALP activity results. ALP activity leads to orthophosphate production and cells tend to store calcium prior to mineralization (Othman, Mustafa, Loon, & Noor, ). Osteogenic commitment of hFOB was observed as an increase in ALP and ICa amounts (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Composite clinoptilolite/PCL‐PEG‐PCL scaffolds for bone regeneration: In vitro and in vivo evaluation

Pazarçeviren

Dikmen

Altunbaş

et al. 2019

J Tissue Eng Regen Med

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In this study, clinoptilolite (CLN) was employed as a reinforcement in a polymer-based composite scaffold in bone tissue engineering and evaluated in vivo for the first time.Highly porous, mechanically stable, and osteogenic CLN/PCL-PEG-PCL (CLN/PCEC) scaffolds were fabricated with modified particulate leaching/compression molding technique with varying CLN contents. We hypothesized that CLN reinforcement in a composite scaffold will improve bone regeneration and promote repair. Therefore, the scaffolds were analyzed for compressive strength, biodegradation, biocompatibility, and induction of osteogenic differentiation in vitro. CLN inclusion in PC-10 (10% w/w) and PC-20 (20% w/w) scaffolds revealed 54.7% and 53.4% porosity, higher dry (0.62 and 0.76 MPa), and wet (0.37 and 0.45 MPa) compressive strength, greater cellular adhesion, alkaline phosphatase activity (2.20 and 2.82 mg/g DNA /min), and intracellular calcium concentration (122.44 and 243.24 g Ca/mg DNA ). The scaffolds were evaluated in a unicortical bone defect at anterior aspect of proximal tibia of adult rabbits 4 and 8 weeks postimplantation. Similar to in vitro results, CLN-containing scaffolds led to efficient regeneration of bone in a dose-dependent manner. PC-20 demonstrated highest quality of bone union, cortex development,and bone-scaffold interaction at the defect site. Therefore, higher CLN content in PC-20 permitted robust remodeling whereas pure PCEC (PC-0) scaffolds displayed fibrous tissue formation. Consequently, CLN was proven to be a potent reinforcement in terms of promoting mechanical, physical, and biological properties of polymer-based scaffolds in a more economical, easy-to-handle, and reproducible approach.

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Effect of Calcium Precursors and pH on the Precipitation of Carbonated Hydroxyapatite

Cited by 36 publications

References 19 publications

Hydroxyapatite for bone related applications derived from sea shell waste by simpleprecipitation method

Hydroxyapatite for bone related applications derived from sea shell waste by simpleprecipitation method

The effect of sintering parameter on the properties of hydroxyapatite from local limestone for bone implant application

Composite clinoptilolite/PCL‐PEG‐PCL scaffolds for bone regeneration: In vitro and in vivo evaluation

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