Effect of calcium on anxiolytic activity of diazepam and verapamil in rats

Hiremath, Sharanabasayyaswamy B.; Anand, Sohit; Ld, Srinivas; Rashed, Mohammad

doi:10.4103/0253-7613.71889

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In India, the prevalence rate of anxiety disorders is 18.5 per 1000 population. (Hiremath et al, 2010) Anxiety issue need aid the practically normal for mental wellbeing issues. It is assessed that they in luence more or less 1 by 10 individuals.…”

Section: Introductionmentioning

confidence: 99%

Extract of zingiber officinale roscoe rhizomes for pharmacological screening anxiolytic activity in rats

Subbarao

Kayalvizhi

et al. 2020

ijrps

View full text Add to dashboard Cite

This project work study was carried out the pharmacological screening of anxiolytic activity of methanolic extract of Zingiber officinale (ginger) rhizomes in the rat. Ginger is an antique therapeutic plant fitting to Zingiberoside family that is formally called as Zingiber officinale Rosc. The behavioral test was measuring by using the two anxiolytics represent actionlike raised plus maze (EPM) and light-dark arena model. The extraction of ginger is approved out by Soxhlet apparatus utilizing methanol as solvent. The ginger extract dose was administered in two groups as 200 mg/kg, p.o. which is compared with control (received vehicle) and standard groups (diazepam 1 mg/kg, i.p.) for its anxiolytic action for 7 days. The dose at 200 mg /kg and 400 mg/kg administered verbally which increase the time spent and no of entry in raised plus maze and growth time consumed inbox and no of crossing between light dark compartment boxes. The consequences of the training work exposed by extracts exhibit anxiolytic activity. Those female-to-male proportion to At whatever lifetime tension issue may be 3:2. The majority uneasiness issue start over childhood, youthfulness What's more initial adulthood. Frenzy issue exhibits a bimodal period about onset in the age gatherings for 15-24 a considerable length of time. Furthermore, 45- 54 a considerable length of time.

show abstract

Section: Introductionmentioning

confidence: 99%

Extract of zingiber officinale roscoe rhizomes for pharmacological screening anxiolytic activity in rats

Subbarao

Kayalvizhi

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…Several studies have demonstrated that acute and chronic administration of Mg reduces immobility time in the forced swimming test (FST) in mice and rats, and enhances the anti-immobility activity of imipramine in this model [11]- [13]. Effects of other bivalent cationic metals such as calcium [14] and zinc [15] on anxiety have been also investigated, although their results showed preliminary anxiolytic effects. However, magnesium has been among the most predominant metal in central nervous system to affect neurotransmission.…”

Section: Introductionmentioning

confidence: 99%

Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice

Jahromy¹,

Golbaghi²,

Mohajer³

et al. 2014

View full text Add to dashboard Cite

Anxiolytic-like activity of magnesium chloride has been exhibited in the elevated plus-maze test in mice, in several studies. Buspirone is an anxiolytic psychoactive drug of the azapirone chemical class that is not related to benzodiazepines, unlike most drugs predominately used. The purpose of the present study was to examine interaction between magnesium (Mg) and buspirone as a partial agonist of 5-HT1A receptors in producing anxiolytic-like activity in the elevated plus maze. The anxiolytic-like effect of Mg (50, 100 and 200 mg/kg, orally), buspirone (5 mg/kg, i.p) and its interaction with Mg (50 mg/kg) was evaluated after ten days treatment. Mg given at all doses (50, 100 and 200 mg/kg) and buspirone (5 mg/kg) induced an anxiolytic-like effect significantly increasing the percentage of the time spent in the open arms (%OAT), the percentage of the open arm entries (%OAE) and number of total entries. Percent time spend in open arms was reduced when buspirone coadministered with Mg (50 mg/kg) compared to Mg alone. However, the number of entries did not change significantly. No synergistic interaction (increased time in open arms and number of open arm entries) between Mg and buspirone was observed, in this test, on the contrary, %OAT preserved about buspirone effects and %OAE remained around Mg effect. The obtained data indicate that Mg may act partly via serotonergic receptors due to buspirone's inhibitory action as a partial agonist of serotonin receptor.

show abstract

Effect of calcium on anxiolytic activity of diazepam and verapamil in rats

Cited by 2 publications

References 9 publications

Extract of zingiber officinale roscoe rhizomes for pharmacological screening anxiolytic activity in rats

Extract of zingiber officinale roscoe rhizomes for pharmacological screening anxiolytic activity in rats

Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice

Contact Info

Product

Resources

About