Effect of calcium-channel blockers on cell proliferation, DNA synthesis and collagen synthesis of cultured gingival fibroblasts derived from human nifedipine responders and non-responders

In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications

“…Frequently, the surface epithelium has elongated rete processes. These findings are in agreement with Gurgel et al, 27 Kanno et al, 28 McKevitt and Irwni, 29 and Fujii et al 30 as they reported that CsA, PNT, and nifedipine led to phased and drug-related gene expression patterns, resulting in impaired collagen metabolism. Leask et al 31 and Chujo et al 32 found an interaction between certain fibroblasts subpopulation and collagen with PNT and its metabolite.…”

Differences of Cell Growth and Cell Cycle Regulators Induced by Basic Fibroblast Growth Factor Between Nifedipine Responders and Non-responders

“…); antiepileptics (phenytoin, sodium valproate, etc. ); and immunosuppressants (cyclosporine A) cause gingival overgrowth as a side effect (1,2). Many case reports have also implicated nifedipine, one of the dihydropyridine calcium-channel blockers, as a cause of gingival overgrowth (1,3).…”

“…Gingival overgrowth refers to a histological enlargement of the tissue caused by an increase in the number of cellular and intercellular elements (1,3). We have previously demonstrated that gingival fibroblasts derived from a nifedipine-reactive patient (nifedipine responder, NIFr) exhibited greater proliferation rates and DNA and collagen syntheses than those from a nifedipine-nonreactive patient (nifedipine non-responder, NIFn) in the presence of 1 µM of nifedipine (1).…”

Prevalence and Risk of Gingival Enlargement in Patients Treated With Nifedipine

“…12,34,35 This, in turn, changes the metabolism of connective tissue fibroblasts, causing an increase in the components of the extracellular matrix, i.e., collagen fibers and/or ground substance. 22,[36][37][38][39][40][41][42][43] Nifedipine is a calcium channel-blocking agent of the dihydropyridine group widely used as a vasodilating agent for the treatment of hypertension and ischemic heart disease. 44,45 Gingival enlargement in patients treated with this drug was originally reported in 1984 by Lederman et al 19 and Ramon et al 21 More recently, gingival enlargement also has been described in patients treated with other dihydropyridines, such as nitrendi-pine, nicardipine, felodipine, and amlodipine.…”