In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications

Expression of CD163 in hereditary gingival fibromatosis: A possible association with TGF‐β1

“…In addition, a notable decrease in the count of CD163‐expressing macrophage cells in the HGF specimens was detected in the current study when compared to the total inflammatory cell count in the (H&E) stained sections (Table ). These preliminary results are in concordance with Almahrog et al, who reported that DIGO tissue samples contain certain subpopulations of macrophages and other inflammatory cells. This finding also supports that the detected type of macrophages in HGF samples, in our study, was confined mainly to M2 phenotype.…”

“…Macrophages of M2c type express high levels of cluster differentiation of (CD163), which was associated with tissue repair, wound remodeling, and promoting cell proliferation in mice . In 2016, Almahrog et al reported that CD163 expressed by M2c immunophenotyped macrophages is remarkably upregulated in GO induced by cyclosporine‐A.…”

The Effect of Local Application of Bisphosphonates in Osseointegration of Dental Implant: An Experimental Study

“…Olympus ® microscope with 1/2 X photo adaptor, using 40 X objective with Olympus ® digital camera installed on it were photographed all slide. Intel ® core I4 ® based computer using Video Test morphology software with specific built-in routine for stain quantification and area measurement were analyzed result images (17) . The mean %BIC values in the study group were approximately 2 times higher than those in the control group, showing a statistically significant difference (P < 0.001) ( Table 1).…”

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

“… 3 , 4 The multifactorial effects on the edema and fibrosis of nasal mucosal tissue and tissue remodeling result in irreversible changes in polypoid tissues. A number of studies revealed that the formation of NPs was due to the increased expression levels of Transforming Growth Factor‐β (TGF‐β), 5 Vascular Endothelial Growth Factor (VEGF), 6 Platelet Derived Growth Factor (PDGF), 7 Arginase 1 (Arg‐1), 8 and other cytokines in local tissues, leading to the excessive proliferation of fibroblasts, accumulation of extracellular matrix, and aggravation of tissue remodeling. On the contrary, the vascular permeability increases under the influence of nasal mucosal inflammation, resulting in edema of the nasal mucosa and accumulation of inflammatory transmitters.…”