Effect of calcium and vitamin D supplements as an adjuvant therapy to metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome patients: A Randomized, Placebo-Controlled Clinical Trial

Objective: To study the prevalence of 25-hydroxyvitamin D deficiency pattern during three year (2017-2020) and severity correlation among individuals with acute traumatic brain injury (TBI). Methodology: Subjects with acute TBI admitted from June 1st, 2017 through June 30th, 2020 were recruited. 280 out of 445 met inclusion criteria. The demographic injury related details, assessment of 25 OH vitamin D and Glasgow Comma (GCS) score were done at the time of admission. Results: The year wise enrolled subjects were young with mean age of 28.39±0.86 years with males (73.3%) and female (23.7%), in first year, 27.77±5.35 years with males (81.67%) and female (18.33%), in second year and 23.04±7.10 years with males (88.57%) and female (11.42%), in third years. Mean value of 25(OH) vitamin D in subjects during three years were 23.78±11.79ng/mL, 21.65±12.53 ng/mL and 25.18±18.58ng/mL. The vitamin D deficiency levels in this study were tabulated as: deficient (level <20 ng/mL), insufficient (level 20–29.9ng/mL), and sufficient (level ≥30ng/mL). Which were found during three years as: In First year, Deficient (64.44%), Sufficient (11.11%), insufficient (24.44%), in second years, Deficient (88.33%), Sufficient (2.66%), insufficient (10.00%) and in third year Deficient (88.57%), Sufficient (1.42%), insufficient (10.00%). In which sufficient level were found to be decreased statistically significant with years with P value= 0.0001. The severity assessment through GCS score were found to be statistically increased with deficient levels with P values=0.0447, but found no significance, when comparison were done between years wise GCS score and levels of vitamin D. Conclusion: The study found decreased prevalence of vitamin D deficiency levels with increased severity. Therefore it should be routinely screened and treated as indicated.

show abstract

Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study

Choudhary

Sharma

Kumar

et al. 2021

RJPT

View full text Add to dashboard Cite

show abstract

Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Ahamed

Sumitra

Chitra

2021

RJPT

View full text Add to dashboard Cite

The polycystic ovarian syndrome is a convoluted endocrine disorder of the reproductive system which influences several girls with puberty and 6-8% of germinating women in endemic populations and displays a wide spectrum of clinical phenomenon. This disorder was first reported in 1935 as a synthetic clinical error for its associations with high androgen levels, hyperinsulinemia, and PCOS. The pineal hormone melatonin is known to regulate a mixture of central and peripheral actions related to circadian rhythms. It is a pleiotropic fragment, which plays a vital role in female reproduction as a capable free radical hunter and involves many gynecological and obstetrical pathology. PCOS is a compound condition for which the symptoms are irregular, and the cause is anonymous. Herbal products like Yastimadhu (Glycyrrhiza glabra), Kumari (Aloe vera), Tvaka (Cinnamomum Zeylanicum), Mostly the Ayurvedic drugs used for the PCOS, all are Vata-kapha shamaka. Neurological associated in pcos is still in the platform of research, no drugs melatonin an important modulator in pcos can be concentrated to cure pcos. Melatonin might be effective against neurological associate pcos. In ayurvedic way of treatment it can be cured with several natural drugs.

show abstract

Effect of Vitamin D Supplementation in patients with Cardiometabolic disorders- A Clinical Study in Ahmedabad population

Basu

Mehta

2022

RJPT

View full text Add to dashboard Cite

Vitamin D deficiency and cardiometabolic disorders are very much widespread in worldwide, India and Ahmedabad region of Gujarat. It was the first study conducted among Gujarati ethnic group of Ahmedabad region, India. The aim of the study was to assess the effects of vitamin D supplementation on cardiometabolic disorders with vitamin D deficiency. The study was performed as an open labeled, randomized, parallel-group, single centric and prospective design at Tej Hospital, Ahmedabad, Gujarat. The dosage regimen of vitamin D supplementation was 60,000 IU/ week for 4 weeks and then 60,000IU once a month for 12 months. Our results showed that vitamin D supplementation causes significant decrease in systolic blood pressure (SBP) at 6 and 12 months as well as significant decrease in triglycerides (TG),very low density lipoprotein (VLDL), fasting blood glucose (FBG), post prandial blood glucose (PPBG) and glycosylated haemoglobin ( HbA1c) with significant increase in 25(OH)D level in vitamin D group at 12 months as compared with non-vitamin D group .Our findings supported that vitamin D deficiency may be a potential risk factor for cardiometabolic disorders and the dosage regimen of vitamin D supplementation is enough to achieve sufficiency and maintain 25(OH)D level which ultimately causes improvement in cardiometabolic disorders.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of calcium and vitamin D supplements as an adjuvant therapy to metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome patients: A Randomized, Placebo-Controlled Clinical Trial

Cited by 3 publications

References 0 publications

Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study

Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study

Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Effect of Vitamin D Supplementation in patients with Cardiometabolic disorders- A Clinical Study in Ahmedabad population

Contact Info

Product

Resources

About