Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Ahamed, Safeeq; Sumitra, Maryam Rachmawati; Chitra, V.

doi:10.52711/0974-360x.2021.00877

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…All the individuals were taking conventional medicines and a modi ed diet plan. However, the intervention group participants were taking 1000 mg/day of evening primrose oil for 10 weeks [30]. The participants were requested not to alter their routine physical activity and take any other nutritional supplement.…”

Section: Methodsmentioning

confidence: 99%

Effect of Evening Primrose Oil on Hyperandrogenism Markers in Women With Polycystic Ovarian Syndrome

Ali,

Javed,

Jabeen

et al. 2023

Preprint

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Objective To evaluate the effect of evening primrose oil on lipid profile, hormonal level and BMI among women suffering from polycystic ovarian syndrome. To evaluate the safety assessment of evening primrose oil among women suffering from polycystic ovarian syndrome. Methodology: The study was conducted among 48 participants with a body mass index (BMI) of 25.0–29.9 who met the inclusion and exclusion criteria. First, all the participants were divided into two groups: the control group (n = 24) and the treatment group (n = 24). The participants were selected from Shoukat Surgical Hospital Gynecology OPD Wards 1 and 2, Depalpur, District Okara. All the participants in the control and treatment groups were given conventional medicines (as per physician recommendation) and a modified diet plan for 10 weeks, but treatment group participants were also given 1000 mg of Evening primrose oil daily. It was requested that the participants not change their usual exercise routine and refrain from using any additional dietary supplements. The samples for biochemical tests of Luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, estrogen, total cholesterol, and low density lipoprotein (LDL) were collected on week 1 and after week 10 of the study. Results Both married and unmarried participants were included in the study. The average mean ages of both groups in control and treatment were 30.16 ± 7.174 and 31.36 ± 5.61 respectively. The mean significant difference in BMI pre and post-treatment in the control group was 26.77 ± 1.48 to 23.22 ± 0.87 and in the treatment group 26.95 ± 1.29 to 22.35 ± 1.30. The mean significant difference in LDL from pretreatment 134.6 ± 20.0 to post treatment 90.4 ± 15.1 and total cholesterol level from pretreatment 234.4 ± 27.1 to post treatment 179.9 ± 24.53 in treatment group was observed. A reduction in levels of the hormones FSH, LH and testosterone was observed, while the estrogen level increased after 10 weeks of study. The mean significant difference of hormones LH pre and post treatment (5.96 ± 1.11 to 4.80 ± 1.08), FSH pre and post treatment (3.74 ± 0.67 to 3.45 ± 0.60), testosterone pre and post treatment (3.64 ± 0.79 to 3.59 ± 0.50), and estrogen pre and post treatment (62.41 ± 8.4 to 76.53 ± 8.79). Conclusion Evening primrose oil (EPO) showed a significant mean difference in the reduction of BMI in overweight participants (p = 0.000). There is a significant mean difference in LDL, total cholesterol, LH, FSH, testosterone, and estrogen.

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Section: Methodsmentioning

confidence: 99%

Effect of Evening Primrose Oil on Hyperandrogenism Markers in Women With Polycystic Ovarian Syndrome

Ali,

Javed,

Jabeen

et al. 2023

Preprint

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“…This suggests that melatonin supplementation may present great therapeutic potential for women with PCOS. [119,120] One newer randomized study explored technology in helping PCOS patients. This research demonstrated that a mobile health application program based on the Transtheoretical Model can lead to long-term reductions in BMI, waist circumference, anxiety, and depression, as well as improvements in exercise and diet adherence among patients with PCOS.…”

Section: New and Emerging Treatmentsmentioning

confidence: 99%

“…This suggests that melatonin supplementation may present great therapeutic potential for women with PCOS. [ 119 , 120 ]…”

Section: Managementmentioning

confidence: 99%

Polycystic ovary syndrome and its multidimensional impacts on women’s mental health: A narrative review

Almhmoud,

Alatassi,

Baddoura

et al. 2024

Medicine

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects approximately 8% to 13% of women of reproductive age worldwide. It is characterized by a range of symptoms, including hirsutism, acne, and menstrual irregularities, and poses a significant psychological burden, including anxiety and depression. The evolving definition of PCOS, from the 1990 NIH conference to the 2003 Rotterdam conference, highlights its multifaceted nature, encompassing metabolic, reproductive, and psychological aspects. This overview aims to elucidate the complex interplay between PCOS’s physiological and psychological dimensions. It focuses on understanding the heightened risk of psychiatric disorders, including depression and anxiety, among women with PCOS and explores the contributing factors, such as obesity, body image issues, and stress. The etiology of PCOS involves a complex mixture of genetic, hormonal, and lifestyle factors that contribute to its pathophysiology and the associated mental health challenges. Stress, in various forms, including metabolic, inflammatory, oxidative, and emotional, is identified as a significant contributor to the pathogenesis of PCOS. Management strategies highlighted include lifestyle modifications, dietary and exercise interventions, and psychological therapies, underscoring the need for comprehensive and integrated care approaches that address the broad spectrum of PCOS effects. A multifaceted treatment approach that goes beyond just the physical symptoms of PCOS to also include its significant psychological effects is emphasized, reinforcing the necessity for a comprehensive, integrated care strategy to manage this complex condition effectively.

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Cerebrospinal Fluid Serotonin level as Biomarker for Neurotoxicity after 3,4-Methylenedioxymethamphetamine (MDMA)

Zakaria

Ismail

N.M.J

2022

RJPT

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A persistent 3,4-Methylenedioxymethamphetamine (MDMA) exposure may disrupt the human body serotonergic system which subsequently leads to physical and psychiatric chaos. Serotonin, a well-known monoamine neurotransmitter which is the main target of MDMA can be found in cerebrospinal (CSF) fluid. Its variation reflects the severity of neuronal damage caused by MDMA exposure. Hence, this article aimed to review the potential of serotonin as biomarker for neuronal damage posed by MDMA. Articles from main databases including PubMed, Scopus and Web of Science were analysed and its information about serotonin variation in cerebrospinal fluid in response to MDMA exposure were extracted. MDMA is affine to serotonergic system, and can represents as a change in the level of serotonin in the CSF. It provides critical information about underlying mechanisms of neuronal damage from neurotoxicity, neurodegenerative process, excitotoxicity and hallucination due to MDMA exposure. Since serotonin variation in the CSF reflects the severity of neuronal damages, serotonin is potentially be used as an early indicator to assess neural injury caused by MDMA that plays an important role in intervention purpose. Serotonin variation in the CSF reflects the severity of neuronal damages. Its variation in CSF can be used as a biomarker for assessing neuronal damage following MDMA exposure.

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Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Cited by 4 publications

References 38 publications

Effect of Evening Primrose Oil on Hyperandrogenism Markers in Women With Polycystic Ovarian Syndrome

Effect of Evening Primrose Oil on Hyperandrogenism Markers in Women With Polycystic Ovarian Syndrome

Polycystic ovary syndrome and its multidimensional impacts on women’s mental health: A narrative review

Cerebrospinal Fluid Serotonin level as Biomarker for Neurotoxicity after 3,4-Methylenedioxymethamphetamine (MDMA)

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