Effect of Caffeine on Circulating Theophylline Levels in Beagle Dogs

Tse, Francis L. S.; Valia, K. H.; Szeto, Daniel W.; Raimondo, Tiziana; Koplowitz, Barry

doi:10.1002/jps.2600700414

Cited by 14 publications

(3 citation statements)

References 21 publications

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“…The most common pDFIs were found between theophylline and caffeine (coffee/tea) with a frequency of 120 (43.16%) ( Table 9), followed by theophyllineprotein-rich foods (fish, milk, and egg) with a frequency of 55 (19.78%). Tse et al conducted a study that suggested that interactions between theophylline and caffeine may be attributed to changes in drug distribution and drug elimination characteristics [20].…”

Section: Ramalingam Et Almentioning

confidence: 99%

Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

Ramalingam

Rajagopal²,

Kandasamy

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to assess the potential drug interactions among hospitalized patients in cardiac and pulmonary wards in three tertiary care hospitals. Methods:A prospective, observational study was carried out for 12 months. A sample of 1150 patients were assessed for potential drug-drug interactions (pDDIs) using Micromedex ® -2.7 and Drugs.com. Results:A total of 1150 patients were analyzed, and it was found that 685 were cardiac and 465 were pulmonary patients. The study identified 524 (76.49%) cardiac patients and 345 (74.19%) pulmonary patients, with pDDIs higher in male cardiac (298 [56.87%]) and male pulmonary (199 [57.68%]) patients, compared to females. Incidences of pDDIs were found to be higher in the age group of 60-70 years in cardiac (193 [36.83%]) and pulmonary (146 [42.31%]) patients and incidences of interactions based on duration of 4-6 days' hospital stays in cardiac were 380 (72.53%) and 215 (62.31%) in pulmonary patients, respectively. Moreover, 51.90% of cardiac patients and 56.52% of pulmonary patients were found to be prescribed with more number of drugs (cardiac 7 drugs and pulmonary 5-6 drugs) causing higher incidences of pDDIs. Some of the most common drug interacting pair was aspirin and clopidogrel combination observed in 245 cardiac patients, whereas in the pulmonary department, it was ranitidine-theophylline combination with a frequency of 195 pDDIs. Drug-food interactions were found with atorvastatin-citrus fruits in cardiac and theophylline-caffeine in pulmonary patients. The most common drug-disease interaction was found to be isosorbide dinitrate-myocardial infarction in cardiac and diazepam-COPD in pulmonary, respectively. Conclusion:Pharmacists must take responsibility in the monitoring of drug interactions and notifying the physician and patient about potential problems. With their detailed knowledge of drugs, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible adverse effects of their drug therapy.

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Section: Ramalingam Et Almentioning

confidence: 99%

Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

Ramalingam

Rajagopal²,

Kandasamy

et al. 2018

Asian J Pharm Clin Res

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show abstract

“…Caffeine is a methylxanthine, similar in structure to theobromine and the commonly quoted acute LD 50 in dogs is 140 to 150 mg/kg (Dolder 2013). Caffeine is rapidly absorbed in dogs with peak plasma concentrations occurring after one to two hours (Tse and others 1981). Caffeine is often present in slimming products for its supposed effects on appetite suppression and the resting metabolic rate (Acheson and others 1980, Liu and others 2015).…”

Section: Breed Quantity Ingested Signs Outcomementioning

confidence: 99%

Raspberry ketone ingestion in dogs

MacCallum

Bates²,

Edwards³

2017

Veterinary Record

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“…Despite plasma concentration monitoring of TP to prevent adverse effects, unexpected adverse effects such as seizures, arrhythmias, and neurologic toxicities have frequently occurred (Hurwitz 1969;Carney 1982;Jonkman et al 1991;Lieberman and Nelson 1993;Benowitz et al 1995). Concurrent use of foods or drugs that are substrates, inhibitors, and/or inducers of CY-P1A2 can result in unwanted changes in plasma concentration of TP, as has been observed in many cases (Conrad and Nyman 1980;Jackson et al 1981;Tse et al 1981;Jonkman and Upton 1984;Sarkar et al 1992;Goasduff et al 1996;Navid et al 2016;Britz et al 2019). Shown in Fig.…”

Section: Introductionmentioning

confidence: 98%

CYP1A2-Mediated Pharmacokinetic Interaction of Caffeine and Theophylline in Mice

Choi,

Yu,

Bae

2023

DTT

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Theophylline (TP) is used to treat chronic obstructive pulmonary diseases, but its narrow therapeutic range limits its use. Changes in cytochrome (CYP)1A2-mediated metabolism can lead to unwanted TP concentration. Caffeine (CA) is frequently used with drugs and is a well-known CYP1A2 substrate, metabolized to paraxanthine (PA), theobromine (TB), and TP. Since CA and TP share overlapping metabolic pathway through CYP1A2, this study investigated how CA and TP pharmacokinetically interact with each other after oral administration of CA, TP, or CA plus TP (CA+TP) in mice. In the CA+TP group, co-administered CA resulted in a 1.61-fold increase in AUC with a 0.63-fold decrease in CL/F of TP compared to the TP group. This may be due to the inhibition of CYP1A2-mediated TP metabolism by CA. Co-administered TP also resulted in a 1.57-fold increase in AUC and a 0.64-fold decrease in CL/F of CA compared to the CA group. This could be due to TP activity to inhibit metabolic pathways, including CYP1A2, involved in CA metabolism. Moreover, the ratios of AUC PA /AUC CA , an indicator of CYP1A2 inhibition, and AUC TB /AUC CA were decreased in the CA+TP group compared to the CA group. These results suggest that the interaction between CA and TP is due to their overlapping CYP1A2-mediated metabolism being inhibited by their co-administration.

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Effect of Caffeine on Circulating Theophylline Levels in Beagle Dogs

Cited by 14 publications

References 21 publications

Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

Raspberry ketone ingestion in dogs

CYP1A2-Mediated Pharmacokinetic Interaction of Caffeine and Theophylline in Mice

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