Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro

Borrelli, Francesca; Posadas, Inmaculada; Capasso, Raffaele; Aviello, Gabriella; Ascione, Valeria; Capasso, Francesco

doi:10.1016/j.ejphar.2005.08.032

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Several studies have reported that among the signs of indomethacin-induced gastric ulcers is increased gastric acidity 20&22 , however in our study the brown propolis extract did not affect the basal gastric acidity or the elevated gastric acidity induced by indomethacin indicating that the propolis extract is truly gastroprotective agent regardless to gastic acidity. Our results were in accord with that of Borrelli et al 23 who reported that the major components of propolis extract did not affect the basal gastric acid secretion nor the secretion stimulated by other stimulants.…”

Section: Histological Evaluation Of Gastric Mucosal Injurysupporting

confidence: 93%

Antioxidant, Lipid Peroxidation-Inhibitory and Antiulcer Activities of Brown Propolis

Mohafez

Abdel-Raheem

Nafady

2010

Bulletin of Pharmaceutical Sciences. Assiut

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The antioxidant activity of the ethanolic extract of brown propolis was determined by invitro antioxidant assays via 1,1-diphenyl-2-picryl-hydrazyl (DPPH·) free radical scavenging activity and phosphomolybdenum method. The brown propolis extract had an effective DPPH· scavenging activity at 20-200µg/ml concentrations. Moreover, the in-vivo experiments showed that brown propolis extract has a powerful antioxidant and lipid peroxidation inhibitory activity in the liver tissues challenged with CCl 4 . On the other hand, we found that pretreatment of rats with propolis extract protected gastric tissues against indomethacin-induced gastropathy as demonstrated from reduction in the ulcer index, attenuation of histopathological changes and amelioration of the altered oxidative stress biomarkers like glutathione, thiobarbituric acid reactive substance levels and superoxide dismutase activity in gastric tissues. In conclusion, total ethanolic extract of brown propolis exposed major anti-oxidant and anti-ulcer activities.

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Section: Histological Evaluation Of Gastric Mucosal Injurysupporting

confidence: 93%

Antioxidant, Lipid Peroxidation-Inhibitory and Antiulcer Activities of Brown Propolis

Mohafez

Abdel-Raheem

Nafady

2010

Bulletin of Pharmaceutical Sciences. Assiut

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“…The compound mediates the antioxidant and anti-inflammatory properties of propolis extracts (5). Several investigations reported its antitumoral activities both in vitro (6,7) and in vivo (8), its antibiotic and antiviral properties (9)(10)(11), and its ability to inhibit acetylcholinesterase activity (12). Moreover, an increasing number of in vivo studies with a systemic administration of 2 in different animal models have been reported (8,(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

In Vitro and in Vivo Stability of Caffeic Acid Phenethyl Ester, a Bioactive Compound of Propolis

Celli

Dragani

Murzilli

et al. 2007

J. Agric. Food Chem.

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The in vitro biochemical stability of caffeic acid phenethyl ester in rat and human plasma was investigated and compared with the stability of other caffeic acid esters (chlorogenic acid and rosmarinic acid). The incubation of the compounds in rat plasma for up to 6 h showed that caffeic acid phenethyl ester, but not the other compounds, was hydrolyzed, whereas human plasma did not affect the stability of all the assayed compounds. The products in rat plasma were caffeic acid and an unknown compound, which was identified by mass spectrometry as caffeic acid ethyl ester, produced by transesterification in the presence of ethanol used as vehicle for standard compounds. Specific inhibitors of different plasma esterases allowed the identification of a carboxylesterase as the enzyme involved in the metabolism of caffeic acid phenethyl ester. The oral administration in rats of caffeic acid phenethyl ester in the presence of both ethanol and 2-(2-ethoxyethoxy)ethanol gave rise to a dramatic increase of caffeic acid, as well as low levels of caffeic acid phenethyl ester, caffeic acid ethyl ester, and caffeic acid 2-(2-ethoxyethoxy)ethyl ester, in urine collected within 24 h after treatment. These results suggest that caffeic acid phenethyl ester is hydrolyzed also in vivo to caffeic acid as the major metabolite and that its biological activities should be more properly assayed and compared with those of caffeic acid, its bioactive hydrolysis product. Moreover, alcohols should be carefully used in vivo as solvents for caffeic acid phenethyl ester, since they can give rise to new bioactive caffeic acid esters.

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“…The inhibitory activity of caffeic acid against AChE and BChE is also reported (IC 50 of 32.4 and 32.2 g/mL, respectively). Previously, Borrelli et al 46 showed the ability of caffeic acid phenethyl ester (CAPE) to inhibit AChE. Luteolin and 3,5-dicaffeoylquinic acid exhibited the most promising activity against AChE with IC 50 of 25.2 and 54.5 g/mL, respectively.…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Conforti

Rigano

Formisano

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro

Cited by 9 publications

References 22 publications

Antioxidant, Lipid Peroxidation-Inhibitory and Antiulcer Activities of Brown Propolis

Antioxidant, Lipid Peroxidation-Inhibitory and Antiulcer Activities of Brown Propolis

In Vitro and in Vivo Stability of Caffeic Acid Phenethyl Ester, a Bioactive Compound of Propolis

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

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