Effect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia–reperfusion injuries

Abstract

Oxygen-derived free radicals have been implicated in the pathogenesis of tissue injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active ingredient of honeybee propolis, has been identified as having potent antioxidant and anti-inflammatory properties. We evaluated the ability of CAPE applied intraperitoneally in reducing tissue injury after ischaemia-reperfusion. To investigate whether treatment with CAPE modifies the concentrations of the endogenous indices of oxidant stress, we examined its effects on a model of flap ischaemia-reperfusion injury in rats. CAPE (10 micromol/kg) was given through the peritoneum before reperfusion. CAPE given intraperitoneally had an inhibitory effect on tissue injury after ischaemia-reperfusion comparable to that of a control group. The anti-inflammatory and antioxidant properties of CAPE may contribute to its suppression of tissue injury.

Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

“…CAPE is a major component of honey bee propolis which is commonly used in Chinese traditional medicine. CAPE was also investigated in various organs such as intestine, lung, and spinal cord in a number of animal models and it has been reported that it has anti-inflammatory, radical scavenging and, therefore, antioxidant activities [ 10 , 11 , 33 – 37 ]. It also has immunomodulatory actions such as inhibition of ROS production and it is also demonstrated to exhibit cytostatic, antiviral, antibacterial, and antifungal properties [ 10 , 11 , 38 – 45 ].…”

Caffeic Acid Phenethyl Ester Decreases Oxidative Stress Index in Blunt Spinal Cord Injury in Rats

“…Group 2 underwent laminectomy followed by SCI and received CAPE 10 µmol/kg by intraperitoneal injection. 4 Group 3 underwent laminectomy followed by SCI and received MP (Prednol-L, Mustafa Nevzat Ilac Sanayi Anonim Sirketi, Istanbul, Turkey) by intraperitoneal injection at a single dose of 30 mg/kg. Following the surgical procedure, the rats were placed in a warming chamber and their body temperatures were maintained at approximately 37 o C until they were completely awake.…”

“…2,3 Caffeic acid phenethyl ester (CAPE), one of the major components of honeybee propolis, was recently found to be a potent free radical scavenger and antioxidant, and is used in folk medicine. [4][5][6] CAPE inhibits 5-lipooxygenase-catalysed oxygenation of linoleic acid and arachidonic acid in the micromolar concentration range. At a concentration of 10 µM, it completely blocks production of reactive oxygen species (ROS) in human neutrophils and the xanthine/xanthine oxidase system.…”