Effects of nebivolol on skin flap survival: A randomized experimental study in rats

Gideroğlu, Kaan; Alagöz, Şahin; Uygur, Fatih; Evinc, Rahmi; Çeli̇köz, Bahatti̇n; Buğdaycı, Güler

doi:10.1016/j.curtheres.2008.10.001

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…In our work, pre-treatment with nebivolol before INDO resulted in significant decreases in gastric MDA levels and significant increases in gastric GSH levels relative to those in the INDO only rats. Nebivolol is thought to possess anti-oxidant activity, possibly by inhibiting NADPH oxidase-induced free radical formation (Morsy et al 2012), direct scavenging of ROS (Goel et al 2009), decreasing free radicals pool (Gideroglu et al 2008) and/or up-regulating hemoxygenase-1 (HO-1) enzyme expression (which augments GSH levels) (Morsy et al 2012). Omeprazole pre-treatment, before INDO, here had the same impact as the nebivolol on MDA and GSH.…”

Section: Discussionmentioning

confidence: 95%

Nebivolol prevents indomethacin-induced gastric ulcer in rats

El-Ashmawy

Khedr

El-Bahrawy

et al. 2016

Journal of Immunotoxicology

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Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (INDO only), omeprazole before INDO and nebivolol before INDO. Each rat to receive nebivolol and omeprazole was given the agent orally (by gavage) daily for 10 days prior to induction of ulcer by oral dosing with INDO. Four hours after INDO treatment, all rats were euthanized and their stomachs obtained for measures of gastric acidity, oxidative stress and inflammatory markers, as well as cytoprotective mediators. The results showed that a single oral dose of INDO (100 mg/kg) induced gastric acidity, an ulcer index of 2900 and significantly increased levels of gastric tumor necrosis factor (TNF)-α and malondialdehyde (MDA) and significantly decreased levels of gastric prostaglandin E2 (PGE2), glutathione (GSH) and nitric oxide (NO), compared to in normal control counterpart stomachs. Giving nebivolol before INDO corrected the gastric acidity and resulted in a significant increase in GSH, PGE2 and NO and a significant decrease in TNFα and MDA gastric levels, compared to ulcer control values. Results obtained with nebivolol were comparable to those with omeprazole; the preventive index in the nebivolol group was 90.7% compared to 94.5% in rats in the omeprazole group. These studies showed that nebivolol provided a valuable role in preventing gastric ulcers induced by INDO and provided a promise for potentially protecting hypertensive patients from experiencing gastric ulcer. Thus, it is possible that, pending further studies, nebivolol could be used for pre-exposure prophylaxis from gastric ulcer in these patients.

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Section: Discussionmentioning

confidence: 95%

Nebivolol prevents indomethacin-induced gastric ulcer in rats

El-Ashmawy

Khedr

El-Bahrawy

et al. 2016

Journal of Immunotoxicology

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“…In the literature, several studies analyze the effect of drugs on the evolution of randomized non-degloving flaps [19][20][21] . Studies evaluating the influence of substances on the development of degloving injuries are scarce.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of cilostazol in experimental model of degloving injuries in rat limbs

Pazio¹,

Santos

Salles

2018

Acta Cir. Bras.

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“…Numerous experimental studies have been performed to increase flap viability, using different pharmacological agents such as nebivolol , sildenafil , taurin and capsaicin with promising results. Carnitine is one of these agents increasing flap viability .…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum fibronectin levels and carnitine administration: an experimental study in rats

Özkan

Kömürcü

Arik

et al. 2013

International Wound Journal

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We aimed to investigate the relationship between dorsal flap viability and serum fibronectin levels in carnitine-administered rats. A total of 24 rats were equally divided into three groups and operated on. Group 1 (sham group n = 8): following surgery, no agent was given. Group 2 (control group, n = 8): following surgery, sterile saline solution at 0·9% with a dose of 100 mg/kg per day for 7 days was administered intraperitoneally. Group 3 (study group, n = 8): following surgery, carnitine with a dose of 100 mg/kg per day for 7 days was administered intraperitoneally. The flap model used was a 10 × 3 cm dorsal flap extending from the tip of the scapula to the hip joint. This was elevated, and then sutured back to its original site. At the end of postoperative day 8, the animals were anaesthetised and blood samples were collected from intracardiac space. Then, the animals were euthanised. Flap viability was then evaluated measuring the surviving area, using a transparent graph paper. Finally, excised tissue was examined histopathologically. The percentages of viable areas in groups 1, 2 and 3 were 64·68 ± 3·37%, 67·35 ± 5·82% and 75·15 ± 3·56%, respectively. The mean value of fibronectin levels in groups 1, 2 and 3 were 22·3 ± 3·5, 23·1 ± 3·5 and 31 ± 6·8 mg/dl, respectively. The results of this study demonstrated that 100 mg/kg carnitine administration led to an increase in flap viability, and increased serum fibronectin levels might have a role in this process.

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Effects of nebivolol on skin flap survival: A randomized experimental study in rats

Abstract: This small, experimental, in vivo animal study found that nebivolol was associated with reduced necrotic random pattern skin flap area. Further studies are needed to clarify these findings.

Cited by 8 publications

References 37 publications

Nebivolol prevents indomethacin-induced gastric ulcer in rats

Nebivolol prevents indomethacin-induced gastric ulcer in rats

Effect of cilostazol in experimental model of degloving injuries in rat limbs

Relationship between serum fibronectin levels and carnitine administration: an experimental study in rats

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