Effect of butyrate on immune response of a chicken macrophage cell line

Zhou, Zhixiong; Packialakshmi, Balamurugan; Makkar, Sarbjeet; Dridi, Sami; Rath, N. C.

doi:10.1016/j.vetimm.2014.09.002

Cited by 58 publications

(43 citation statements)

References 54 publications

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“…Based on the fact that immunotherapy has been employed in the treatment of glioma [16], SEB can regulate skewed immune responses [17] and increases the development of Th9 cells as shown by the present data, we inferred that SEB might be able to enhance the immunotherapeutic effects on glioma. To test the inference, we developed a glioma-carrying mouse model.…”

Section: Resultssupporting

confidence: 54%

Induction of specific T helper-9 cells to inhibit glioma cell growth

Zheng

Yang

et al. 2016

Oncotarget

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The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB. We observed that treating glioma-bearing mice with the glioma Ag and SEB induced glioma-specific Th9 cells in both glioma tissue and the spleen. Treating CD4+ CD25− T cells with SEB increased p300 phosphorylation, histone H3K4 acetylation at the interleukin (IL)-9 promoter locus, and increased the IL-9 transcriptional factor binding to the IL-9 promoter. Treating CD4+ CD25− T cells with both SEB and glioma Ag induced glioma-specific Th9 cells. The glioma-specific Th9 cells induced glioma cell apoptosis in the culture. Treating the glioma-bearing mice with SEB and glioma Ag significantly inhibited the glioma growth. In conclusion, SEB plus glioma Ag immunotherapy inhibits the experimental glioma growth, which may be a novel therapeutic remedy for the treatment of glioma.

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Section: Resultssupporting

confidence: 54%

Induction of specific T helper-9 cells to inhibit glioma cell growth

Zheng

Yang

et al. 2016

Oncotarget

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“…These cells maintain the immune system framework. The effect of butyrate on macrophage cell line was reported by Zhou et al [27]. They noted that butyrate inhibited nitric oxide production, and diminished the cytokines expression, including IL-6, IL-10, interferon gamma, and IL-1β, which controlled inflammation and maintained immune homeostasis.…”

Section: Discussionmentioning

confidence: 72%

Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Sikandar

Zaneb

Younus

et al. 2017

Asian-Australas J Anim Sci

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ObjectiveThis study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine.MethodsA total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected.ResultsCell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups.ConclusionIn conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

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“…(possibly due to the downregulation of genes in SPI1) through intestinal epithelium (Van Immerseel et al, 2003;Gantois et al, 2006). Sodium butyrate can inhibit the nitric oxide production and expression of cytokines such as IL-1β, IL-6, IFN-γ, and IL-10 in chicken macrophage cells stimulated by the presence of S. typhimurium lipopolysaccharides (Zhou et al, 2014).…”

Section: Immunitymentioning

confidence: 99%

“…It improves body weight, feed conversion ratio (FCR), beneficial bacterial populations, and reduces the colonisation of harmful bacteria in the digestive tract of broilers (Chamba et al, 2014;Zhang et al, 2011;Hu and Guo, 2007;Hernandez et al, 2013). In addition, sodium butyrate supplementation has been linked to improving immunity in broilers (Zhou et al, 2014). In this review, published data relating to the used and benefit of sodium butyrate in poultry diets is discussed.…”

Section: Introductionmentioning

confidence: 99%

Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

Ahsan

Cengiz

Raza

et al. 2016

World's Poultry Science Journal

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The effect of sodium butyrate on various bodily parameters of broilers such as performance, gut microflora, gut morphology, and immunity is reviewed in order to highlight its importance as an alternative to antibiotic growth promoters. Sodium butyrate is used as a source of butyric acid, which is known for its beneficial effects in the gut in monogastrics. Sodium butyrate is available in uncoated and entericcoated forms protected with fat or fatty acid salts. Varying results in productive performance, gut microbes, and gut morphology have been reported in the literature in response to supplementation of broiler diets with uncoated and fatcoated types of sodium butyrate. However, sodium butyrate has shown pronounced effects on immunity of chickens that are not fully understood yet. Although there are contrasting results of sodium butyrate in chicken, further research is needed using the sodium butyrate coated with the salts of fatty acids.

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Effect of butyrate on immune response of a chicken macrophage cell line

Cited by 58 publications

References 54 publications

Induction of specific T helper-9 cells to inhibit glioma cell growth

Induction of specific T helper-9 cells to inhibit glioma cell growth

Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

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