Effect of buckwheat extract on free radical generation in rabbits administered high‐fat diet

Wójcicki, J; Samochowiec, L; Gonet, B; Juźwiak, S.; Dabrowska‐Zamojcin, E.; Katdońska, M.; Tustanowski, S

doi:10.1002/ptr.2650090503

Cited by 17 publications

(6 citation statements)

References 10 publications

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“…The antioxidant activity and MDA content in the duodenum had a similar trend in the liver. When following a HFD, the vigorous intestinal energy metabolism could produce a large amount of ATP, accompanied by the production of a large number of free radicals (Sudhakara et al., ; Wójcicki et al., ). The formation of superoxide anion and other reactive oxygen species can cause oxidative stress and amplify the toxic effects of the bile acids (Jiang, Zhang, Wang, Liu, & Xu, ; Zhou, Wang, & Ying, ).…”

Section: Resultsmentioning

confidence: 99%

Regulatory Function of Buckwheat‐Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High‐Fat Diet

Zhou¹,

Zhao

Yue

et al. 2019

Journal of Food Science

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Buckwheat‐resistant starch (BRS) has shown to be a nutrient capable of lowering cholesterol and reducing obesity. In this study, the regulatory effects of tartary buckwheat starch on blood lipid level and gut microbiota (Lactobacillus, Bifidobacterium, Enterococcus, and Escherichia coli) in mice fed with a high‐fat diet was investigated. Male C57BL/6 mice were separately fed with a normal diet (CON), a high‐fat diet (HFD), and high‐fat diet supplemented with buckwheat‐resistant starch (HFD+BRS) for 6 weeks. After the feedings, lipid profile, blood glucose, plasma levels of cytokines, short‐chain fatty acid content in the colon and intestinal flora of fecal were measured. Furthermore, the antioxidant indices of the liver and duodenum tissues were measured to evaluate the antioxidant capacity of mice. Significantly reduced plasma levels of total cholesterol (TC), triglyceride (TG), glucose, and cytokines were observed in the HFD+BRS group, accompanied by an increased antioxidant capacity in the liver and duodenum. In addition, supplementation with BRS significantly inhibited the increase in plasma lipopolysaccharide, tumor necrosis factor‐α, and interleukin‐6 levels. Gut microbiota composition was regulated by the supplement of BRS, which promoted the growth of Lactobacillus, Bifidobacterium, and Enterococcus, as well as inhibited the growth of Escherichia coli. In contrast to the HFD group, the content of short‐chain fatty acids in mice colon increased in the BRS group. In conclusion, BRS benefited the cholesterol and glucose metabolism, as well as optimized gut microbiota composition in mice fed with a high‐fat diet. Practical Application This study identified the beneficial effects of tartary buckwheat‐resistant starch on the regulation of blood lipids and intestinal flora in mice fed a high‐fat diet. The result of this study will provide a basis for the development of probiotic products supplemented with tartary buckwheat‐resistant starch and direction for further research.

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Section: Resultsmentioning

confidence: 99%

Regulatory Function of Buckwheat‐Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High‐Fat Diet

Zhou¹,

Zhao

Yue

et al. 2019

Journal of Food Science

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“…Apart from glutathione, γ‐tocopherol and ascorbic acids are important free‐radical scavengers, which protect cell membrane against toxic agents. Vitamins C and E have been shown to exhibit synergistic action in scavenging oxygen‐derived free radicals (Wojcicki, et al, ). Ascorbic acid is a potent scavenger of reactive oxygen species in serum and liver (Inoue, ).…”

Section: Discussionmentioning

confidence: 99%

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Senthilkumar¹,

Thangam

Murugan

et al. 2018

J Food Biochem

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The present investigation evaluates the hepato‐protective potential of R‐phycoerythrin (R‐PE)‐rich protein extract obtained from Portieria hornemannii (Lyngbye) Silva against H2O2‐induced hepatotoxicity using HepG2 cells (in vitro) and male Wistar albino Hepatocellular carcinoma (HCC) rats (in vivo). H2O2 treatment led to dose‐dependent decreases in cell viability of HepG2, which was ameliorated by the treatment with R‐PE‐rich extract. In vivo studies showed that all the vital parameters including enzymatic and nonenzymatic antioxidants as well as liver marker enzymes were affected in the experimentally induced HCC male Wistar rats upon exposure to the N‐diethylnitrosamine (DEN), a carcinogen. However, there was moderate to better restoration of such parameters in the carcinoma rats treated with R‐PE‐rich protein extract. Practical applications Therapeutic alternatives originating from food or food supplements are gaining popularity as “nutritional therapy” and they are well studied for their chemo‐preventive effects. Investigations of several food‐derived bioactive compounds revealed their ability to antagonize dysregulated targets in cellular signaling pathways to exhibit antineoplastic activities. Isolation of bioactive molecules present in marine food products and determination of their broad range pharmaceutical activity by means of deducing specific molecular targets as well as establishing minimal toxicity to normal tissues could aid in treatment of cancer. Phycobiliproteins are an important group of pigment molecules extracted from the red and blue green algae. A study was envisaged to evaluate the anticancer potential of RPERPE (R‐PE‐rich protein extract) obtained from P. hornemannii (Lyngbye) Silva against HCC using male Wistar albino rats as models. This study offers the scope of using the R‐PE‐rich protein extract of P.hornemannii for developing therapeutic anticancer formulation.

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“…In reference to that, quercetin and quercetin glycoside, such as rutin and iso-quercetin, have been identified as the major flavonoids in buckwheat, which provide several pharmacological advantages. Many polyphenolics exhibit antioxidative properties, especially oxygen species scavenging [27][28][29][30]. Buckwheat proteins have a high biological value, with a high lysine content, approximately 6 mg/100 g of proteins [31].…”

Section: Introductionmentioning

confidence: 99%

Total and Partial Fat Replacement by Gelled Emulsion (Hemp Oil and Buckwheat Flour) and Its Impact on the Chemical, Technological and Sensory Properties of Frankfurters

Botella‐Martínez

Viuda‐Martos

Pérez‐Álvarez

et al. 2021

Foods

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A gelled emulsion (GE) prepared with hemp oil and buckwheat flour was used to replace pork back fat in frankfurters. Five different formulations were prepared: control (with 35% pork back fat—SC), and the following four to achieve 25%, 50%, 75%, and 100% pork back fat substitution by GE (S1, S2, S3, and S4, respectively). Nutritional, technological, and sensorial characteristics of frankfurters were evaluated. Sausages containing GE presented a lower total fat content with a higher amount of polyunsaturated fatty acids, increased omega 3 content, and reduced saturated fat by up to 55%. The incorporation of GE did not significantly modify technological properties such as emulsion stability or lipid oxidation in spite of using vegetable oils highly susceptible to oxidation. The reformulation of the frankfurters presented a greater effect on the texture and sensory properties when GE was used as total substitution for the pork back fat (S4). When GE was used only as partial substitution for the pork back fat, sausages similar to control frankfurter were obtained. So this study demonstrated that the use of GE could be a promising strategy in the reformulation of healthier meat products.

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Effect of buckwheat extract on free radical generation in rabbits administered high‐fat diet

Cited by 17 publications

References 10 publications

Regulatory Function of Buckwheat‐Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High‐Fat Diet

Regulatory Function of Buckwheat‐Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High‐Fat Diet

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Total and Partial Fat Replacement by Gelled Emulsion (Hemp Oil and Buckwheat Flour) and Its Impact on the Chemical, Technological and Sensory Properties of Frankfurters

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