Effect of bronchoconstrictive aerosols on pulmonary gas trapping in the A/J mouse

RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice

“…Using Archimedes’ Principle, the lungs and weight were placed in a beaker, immersed in saline, ensuring the lung remained submerged by the saline (tarring for the weight of the beaker, weight, trachea cannula and weight). Since lung tissue density is the same as that of saline, the weight displayed by the balance closely approximated the mLs of gas trapped in the lung [31–32]. …”

Insight into Pulmonary Gas Trapping as an Index of Airway Responses in Small Laboratory Animals

“…Further, we found a correlation between in vivo enhanced pause (Penh) determined by whole-body barometric plethysmography [21] and ELGV in naïve mice challenged with methacholine [22]. Finally, we showed that the rank order of methacholine-induced increases in pulmonary gas trapping of naïve male A/J, BALB/c and C3H/HeJ mice [23,24] was similar to that observed for the same mouse strains using airway pressure-time index to measure airway responsiveness to acetylcholine [25]. Thus, collectively these investigations validate the use of pulmonary gas trapping in small laboratory animals for modeling pulmonary functional aspects of human lung diseases.…”