Effect of Brazil Nut Supplementation on Plasma Levels of Selenium in Hemodialysis Patients: 12 Months of Follow-up

Stockler‐Pinto, Milena Barcza; Lobo, Julie Calixto; Moraes, Cristiane; Leal, Viviane O.; Farage, Najla Elias; Rocha, Ariana Vieira; Boaventura, Gilson Teles; Cozzolino, Sílvia Maria Franciscato; Malm, Olaf

doi:10.1053/j.jrn.2011.08.011

Cited by 34 publications

(20 citation statements)

References 30 publications

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“…Brazil nuts (Bertholletia excelsa, family Lecythidaceae) are the richest known food source of selenium. Our research group have shown that the supplementation of one Brazil nut per day for 3 months is effective in raising serum selenium and GPx levels, improving lipid profiles, and reducing levels of inflammatory cytokines (TNF‐α and IL‐6) . In addition, this nut seems to increase the Nrf2 expression (a factor that plays an important role in protecting cells against oxidative stress and inflammation) and reducing NFκ‐B expression (a nuclear factor that is involved in proinflammatory processes) in HD patients (unpublished data).…”

Section: Summary Of Studies Of Zinc Supplementation In Hemodialysis Pmentioning

confidence: 89%

Can Outcomes be Improved in Dialysis Patients by Optimizing Trace Mineral, Micronutrient, and Antioxidant Status?

Mafra

2015

Seminars in Dialysis

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Section: Summary Of Studies Of Zinc Supplementation In Hemodialysis Pmentioning

confidence: 89%

Can Outcomes be Improved in Dialysis Patients by Optimizing Trace Mineral, Micronutrient, and Antioxidant Status?

Mafra

2015

Seminars in Dialysis

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“…The values in the northeastern region has consubstantiated to the consumption of Brazil nuts, which contain high amounts of selenium due to the high concentration of this micronutrient in the soil. Stockler-Pinto et al [ 20 - 22 ], determined the selenium content in foods consumed in Brazil from samples taken from the retail trade in several states and showed higher levels of selenium in plasma of hemodialysis patients. Selenium contents in foods of plant origin were observed to be generally below 5.0μg/100g.…”

Section: Discussionmentioning

confidence: 99%

“…The tissue levels depend on daily intake and the form in which Se is consumed, as well as on the chemical form found and metabolism [ 18 , 19 ]. Associated with this is also the case that selenemia in people from seleniferous regions surpasses those of non-seleniferous areas, especially when observed with antitumor actions [ 20 - 22 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Inflammatory Profile on Selenium Levels in Hemodialysis Patients

Bacci

Cabral

Veiga

et al. 2020

AIAAMC

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Introduction: Hemodialysis stands out as an eligible treatment for patients with chronic kidney disease. The subsequent inflammatory process resulting from this disease and hemodialysis per se is exacerbated in this therapy. Selenium (Se) is an essential trace element that can participate in the inhibition of pro-oxidant and pro-inflammatory processes and could be considered a measurement that indicates the progression of chronic kidney disease and inflammation. Objective: The present study investigated selenemia in hemodialysis patients of the ABC region of São Paulo and aimed to establish the correlation between an inflammatory marker and selenemia in this conditions disease. Methods: This is an observational cross-sectional study of the Faculdade de Medicina do ABC in patients submitted to hemodialysis three times a week for at least six months. The eligible group composed of 21 patients, who filled out forms and underwent biochemical tests (colorimetric enzyme methods, flow cytometer, turbidimetric method and mass spectrometry). Results: The study population showed, women (70%), men (30%) with a mean age of 47 ± 17 years, Caucasians (36%) and non-Caucasian (64%), hypertensive (68%), smokers (53%) and non-smokers (64%). There was a hegemonic prevalence of systolic arterial hypertension (SAH) 68.1% in relation to diabetes mellitus (DM) (50%). Pre and post hemodialysis (HD) selenemia showed statistical significance, which did not occur with Creactive protein. There was a predominance of females in our sample; the pre- and post- HD selenemia were within the normal range of the reference values; there was a statistically significant correlation between pre and post-HD selenemia; there was no correlation with statistical significance between values of pre and post-HD C-reactive protein. Conclusion: Our data showed that there was no direct relationship between pre- and post- HD inflammation and pre- and post-HD selenemia.

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“…Our study showed that baru supplementation was able to increase GPx activity. An increase in GPx activity was also observed with a daily intake of one Brazil nut by patients on hemodialysis [9,26] and obese women [10]. Brazil nuts provide a rich natural source of selenium which increase selenium status and consequently GPx activity [10].…”

Section: Discussionmentioning

confidence: 99%

Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial

et al. 2019

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Background: Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable of improving the inflammatory and antioxidant status in overweight and obese women. Methods: In a parallel-arm, randomized placebo-controlled trial, 46 overweight and obese women (age: 40 ± 11 years; body mass index: 33.3 ± 4.3) were randomly assigned to receive advice to follow a normocaloric and isoenergetic diet with placebo (PLA, n = 22) or similar advice plus 20 g baru almonds (BARU, n = 24) for 8 wk. Malondialdehyde (MDA), adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, antioxidant enzymes activities (catalase—CAT; glutathione peroxidase—GPx; superoxide dismutase—SOD), and minerals were analyzed in plasma samples. Results: At baseline, groups were similar regarding the body composition, oxidative, and inflammatory parameters. The BARU group increased the activity of GPx (+0.08 U/mg, 95%CI + 0.05 to +0.12 vs. −0.07, 95%CI −0.12 to −0.03, p < 0.01) and plasma copper concentration (p = 0.037) when compared to the PLA group. No differences were observed between groups in CAT and SOD activity or MDA and cytokines concentrations. Conclusions: Baru almond supplementation increased the GPx activity in overweight and obese women.

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Effect of Brazil Nut Supplementation on Plasma Levels of Selenium in Hemodialysis Patients: 12 Months of Follow-up

Cited by 34 publications

References 30 publications

Can Outcomes be Improved in Dialysis Patients by Optimizing Trace Mineral, Micronutrient, and Antioxidant Status?

Can Outcomes be Improved in Dialysis Patients by Optimizing Trace Mineral, Micronutrient, and Antioxidant Status?

The Impact of Inflammatory Profile on Selenium Levels in Hemodialysis Patients

Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial

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