Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise

VanDusseldorp, Trisha A.; Escobar, Kurt A.; Johnson, Kelly E.; Stratton, Matthew T.; Moriarty, Terence; Cole, Nathan; McCormick, James J.; Kerksick, Chad M.; Vaughan, Roger A.; Dokładny, Karol; Kravitz, Len; Mermier, Christine M.

doi:10.3390/nu10101389

Cited by 59 publications

(66 citation statements)

References 54 publications

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“…This is the second study with which our research group has utilized lower body eccentric resistance exercise to induce skeletal muscle damage in order to study recovery. Like a previous investigation [47], it appears from the significant time effects and magnitude of responses that the exercise protocol adequately induced skeletal muscle damage, as indirectly assessed by the post-exercise increases in participants' CK and LDH concentrations, reductions in muscular performance, and increases in perceived soreness. Thus, we are confident that we were able to adequately examine the impact of different FO dosages on recovery.…”

Section: Discussionmentioning

confidence: 85%

Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise

et al. 2020

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Fish oils (FOs) are rich in omega-3 long-chain polyunsaturated fatty acids, which have been purported to enhance recovery of muscular performance and reduce soreness post-exercise. However, the most effective FO dose for optimizing recovery remains unclear. The purpose of this investigation was to examine the effect of FO supplementation dosing on the recovery of measures of muscular performance, perceived soreness, and markers of muscle damage following a rigorous bout of eccentric exercise. Thirty-two college-aged resistance-trained males (~23.6 years, 71.6 kg, 172.1 cm) were supplemented with 2, 4, 6 g/day (G) FO or placebo (PL) for ~7.5 weeks. Following 7 weeks of supplementation, pre-exercise (PRE) performance assessments of vertical jump (VJ), knee extensor strength, 40-yard sprint, T-test agility, and perceived soreness were completed prior to a bout of muscle-damaging exercise and were repeated immediately post (IP), 1-, 2-, 4-, 24-, 48-, and 72-h (H) post-exercise. Repeated measures analysis of variance indicated a treatment × time interaction (p < 0.001) for VJ and perceived soreness, but no group differences were observed at any time point. VJ returned to PRE (54.8 ± 7.9 cm) by 1H (51.8 ± 6.5 cm, p = 0.112) for 6G, while no other groups returned to baseline until 48H. Lower soreness scores were observed in 6G compared to PL at 2H (mean difference [MD] = 2.74, p = 0.046), at 24H (MD: 3.45, p < 0.001), at 48H (MD = 4.45, p < 0.001), and at 72H (MD = 3.00, p = 0.003). Supplementation with 6G of FO optimized the recovery of jump performance and muscle soreness following a damaging bout of exercise.

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Section: Discussionmentioning

confidence: 85%

Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise

et al. 2020

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“…However, the strategy of using protein and BCAA supplements to alleviate post-exercise DOMS, muscle damage, performance decrements, and inflammation does not have strong literature support. Interpretation has been hampered by weaknesses in study designs [ 27 , 28 , 29 , 30 , 31 , 32 , 36 , 41 , 42 , 43 , 44 , 45 ]. Study limitations in this area often include small sample sizes, providing low statistical power to evaluate the large interindividual variance typically found for surrogate biomarkers of muscle damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial

et al. 2020

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This randomized trial compared pea protein, whey protein, and water-only supplementation on muscle damage, inflammation, delayed onset of muscle soreness (DOMS), and physical fitness test performance during a 5-day period after a 90-min eccentric exercise bout in non-athletic non-obese males (n = 92, ages 18–55 years). The two protein sources (0.9 g protein/kg divided into three doses/day) were administered under double blind procedures. The eccentric exercise protocol induced significant muscle damage and soreness, and reduced bench press and 30-s Wingate performance. Whey protein supplementation significantly attenuated post-exercise blood levels for biomarkers of muscle damage compared to water-only, with large effect sizes for creatine kinase and myoglobin during the fourth and fifth days of recovery (Cohen’s d > 0.80); pea protein versus water supplementation had an intermediate non-significant effect (Cohen’s d < 0.50); and no significant differences between whey and pea protein were found. Whey and pea protein compared to water supplementation had no significant effects on post-exercise DOMS and the fitness tests. In conclusion, high intake of whey protein for 5 days after intensive eccentric exercise mitigated the efflux of muscle damage biomarkers, with the intake of pea protein having an intermediate effect.

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“…Elevation of serum blood CK within 24/72 h postexercise is recognized as a marker of muscle damage caused by intense eccentric and resistance training [71,72], and its severity also depends on exercise intensity [73]. BCAA supplementation, under specific circumstances (high dosage,.…”

Section: Discussionmentioning

confidence: 99%

Effects of a commercially available branched-chain amino acid-alanine-carbohydrate-based sports supplement on perceived exertion and performance in high intensity endurance cycling tests

Gervasi

Sisti

Amatori

et al. 2020

Journal of the International Society of Sports Nutrition

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Background: Sports nutritional supplements containing branched-chain amino acids (BCAA) have been widely reported to improve psychological and biological aspects connected to central fatigue and performance in endurance exercise, although the topic is still open to debate. The aim of the present study was to determine whether the intake of a commercially available BCAA-based supplement, taken according to the manufacturer's recommendations, could affect the rating of perceived exertion (RPE) and performance indexes at the beginning (1d) and end of a 9-week (9w) scheduled high intensity interval training program, with an experimental approach integrating the determination of psychometric, performance, metabolic and blood biochemical parameters. Methods: This was a randomized double-blind placebo-controlled study. Thirty-two untrained, healthy young adults (20 males and 12 female) were enrolled. A high-intensity endurance cycling (HIEC) test was used to induce fatigue in the participants: HIEC consisted in ten 90 s sprints interspersed by ten 3 min recovery phases and followed by a final step time to exhaustion was used. In parallel with RPE, haematological values (creatine kinase, alanine, BCAA, tryptophan, ammonia and glucose levels), and performance indexes (maximal oxygen consumption-VO 2max , power associated with lactate thresholds-W LT1 , W LT2 and time to exhaustion-TTE) were assessed. All subject took the supplement (13.2 g of carbohydrates; 3.2 g of BCAA and 1.6 g of L-alanine per dose) or placebo before each test and training session. Dietary habits and training load were monitored during the entire training period. Results: The administration of the supplement (SU) at 1d reduced RPE by 9% during the recovery phase, as compared to the placebo (PL); at 9w the RPE scores were reduced by 13 and 21% during the sprint and recovery phase, respectively; at 9w, prolonged supplement intake also improved TTE and TRIMP. SU intake invariably promoted a rapid increase (within 1 h) of BCAA serum blood levels and prevented the post-HIEC tryptophan: BCAA ratio increase found in the PL group, at both 1d and 9w. There was no difference in dietary habits between groups and those habits did not change over time; no difference in glycemia was found between SU and PL. VO 2max , W LT1 and W LT2 values improved over time, but were unaffected by supplement intake.

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Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise

Cited by 59 publications

References 54 publications

Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise

Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise

Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial

Effects of a commercially available branched-chain amino acid-alanine-carbohydrate-based sports supplement on perceived exertion and performance in high intensity endurance cycling tests

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