Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise

VanDusseldorp, Trisha A.; Escobar, Kurt A.; Johnson, Kelly E.; Stratton, Matthew T.; Moriarty, Terence; Kerksick, Chad M.; Mangine, Gerald T.; Holmes, Alyssa J.; Lee, Matthew; Endito, Marvin R.; Mermier, Christine M.

doi:10.3390/nu12082246

Cited by 14 publications

(39 citation statements)

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“…This study follows VanDusseldorp et al, 2020 [ 8 ] who observed reductions in muscle damage and recovery after an acute bout of eccentric resistance exercise with 7.5 weeks of 6 g of n-3 supplementation consisting of a 2:1 ratio of EPA to DHA in resistance-trained males. Therefore, the purpose of this study was to investigate the effect of 33 days of 6 and 8 g of n-3 supplementation on markers of EIMD and muscle recovery after an acute bout of muscle-damaging eccentric resistance exercise in resistance-trained males.…”

Section: Introductionmentioning

confidence: 74%

“…1 ). Conjugated linoleic acid was chosen as the placebo, as it has been used as such in VanDusseldorp et al, 2020 [ 8 ] and is characteristically similar to the omega-3 capsules. Participants were given written and verbal instructions on supplement duration, number of capsules to be taken per day, and dietary restrictions throughout the course of the study.…”

Section: Methodsmentioning

confidence: 99%

“…On day 30, participants completed an acute bout of eccentric resistance exercise. The protocol employed has been used in previous work and has been shown to produce EIMD [ 8 , 23 ]. The exercise protocol consisted of ten sets of eight repetitions at 70% 1-RM barbell back squat with a 4-s eccentric phase followed by five sets of ten per side body weight split squat jumps upon completion of back squats.…”

Section: Methodsmentioning

confidence: 99%

“…However, the literature on n-3 supplementation and EIMD is currently inconclusive, which likely stems from variations in dose, ratios of EPA and DHA, duration of supplementation, source of supplementation, as well as training status and exercise protocols employed. Nonetheless, there are emerging data demonstrating that n-3 supplementation attenuates EIMD in response to resistance exercise, particularly at higher doses [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it is not clear if n-3 doses greater than those used in previous work (>3.6 g/day) produce more robust and consistent effects. However, VanDusseldorp et al, 2020 [ 8 ] showed ∼7.5 weeks of 6 g of n-3 supplementation with an EPA to DHA ratio of 2:1 (400:300 mg per 1000 mg pill) attenuated plasma CK and lactate dehydrogenase (LDH) levels, mitigated perceived muscle soreness (PMS), and promoted vertical jump height (VJH) recovery in resistance-trained individuals within 72-hr post-eccentric resistance exercise compared to placebo, 2 g, and 4 g of n-3 supplementation [ 8 ]. Previous work in untrained individuals demonstrates ∼4 weeks of n-3 supplementation (at lower doses) is capable of mitigating markers of EIMD [ 10 , 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of varying doses of omega-3 supplementation on muscle damage and recovery after eccentric resistance exercise

et al. 2021

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Background Exercise-induced muscle damage (EIMD) commonly occurs following intense resistance exercise and is associated with decrements in exercise performance and delayed muscle recovery. Thus, practical methods to attenuate EIMD would prove useful to both training and athletic populations. Omega-3 (n-3) supplementation has been shown to mitigate EIMD with evidence of increasing efficacy at higher doses (up to 6 g/day). However, data of its efficacy in trained individuals is limited. Therefore, this study investigated the effects of 6 and 8 g of n-3 supplementation on markers of muscle damage and muscle recovery after eccentric resistance exercise in resistance-trained males. Methods Using a double-blind, randomized, placebo-controlled design, 26 resistance trained males (23 ± 4 years; 173.6 ± 20.5 cm; 81.9 ± 9.7 kg; 14.2 ± 3.7% body fat) supplemented with 6 (n=10) or 8 g (n=7) of n-3 polyunsaturated fatty acids, or placebo (n=9) for 33 days. On day 30, participants performed a lower body muscle-damaging eccentric resistance exercise bout. Measures of muscle performance, soreness, and damage were taken pre-exercise on day 30 as well as on days 31–33, including vertical jump height (VJH), perceived muscle soreness (PMS), hip and knee range of motion (ROM), repetitions to fatigue (RTF) at 70% 1-RM, and serum creatine kinase (CK) while participants continued to supplement until day 33. Results There were significant differences in VJH, PMS, and serum CK following the muscle-damaging exercise bout compared to pre-exercise ( p <0.05). However, there were no significant ( p >0.05) differences between supplementation groups (6 g, 8 g, and placebo) at any time point post-exercise (day 31–33). There were no changes in hip and knee ROM or RTF at any time point or between groups. Vertical jump height and PMS returned to pre-exercise levels despite CK remaining elevated post-exercise. Conclusions Thirty-three days of 6 and 8 g of n-3 supplementation did not attenuate EIMD or enhance muscle recovery following muscle-damaging eccentric resistance exercise in resistance-trained males. Further research using various n-3 supplementation durations, doses, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) concentrations may be needed to establish its efficacy in attenuating EIMD, which may vary between trained and untrained individuals. Furthermore, while circulating CK is commonly used to assess muscle damage, elevated CK levels may not reflect muscle recovery status following muscle-damaging exercise.

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Section: Introductionmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 99%