Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile

Cuesta, Lucía Martinez; Lirón, Juan Pedro; Farías, María Victoria Nieto; Dolcini, Guillermina Laura; Ceriani, María Carolina

doi:10.1371/journal.pone.0234939

Cited by 6 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mycoplasma bovis is a known cause of mastitis leading to decreased milk production and significant economic losses. Further, B4GALT5 was found to be expressed in bovine mammary epithelial cells and involved in upregulating the immune system during bovine leukemia virus infection, resulting in a decrease in the incidence of mastitis [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, these genes have also been implicated in various traits in other cattle populations, indicating their potential multifunctional roles. While some of these associations involved biological functions related to adaptation traits, others were linked to specific diseases and infections [24][25][26][27][28][29][30][31][32].…”

Section: Genome-wide Association Analysismentioning

confidence: 99%

See 1 more Smart Citation

Genetic factors influencing milk and fat yields in tropically adapted dairy cattle: insights from quantitative trait loci analysis and gene associations

Laodim,

Koonawootrittriron,

Elzo

et al. 2024

Anim Biosci

View full text Add to dashboard Cite

Objective: The objective of this study was to identify genes associated with 305-day milk yield (MY) and fat yield (FY) that also influence the adaptability of the Thai multibreed dairy cattle population to tropical conditions.Methods: A total of 75,776 imputed and actual single nucleotide polymorphisms (SNPs) from 2,661 animals were used to identify genomic regions associated with MY and FY using the single-step genomic best linear unbiased predictions. Fixed effects included herd-yearseason, breed regression, heterosis regression and calving age regression effects. Random effects were animal additive genetic and residual. Individual SNPs with a p-value smaller than 0.05 were selected for gene mapping, function analysis, and quantitative trait loci (QTL) annotation analysis.Results: A substantial number of QTLs associated with MY (9,334) and FY (8,977) were identified by integrating SNP genotypes and QTL annotations. Notably, we discovered 17 annotated QTLs within the health and exterior QTL classes, corresponding to nine unique genes. Among these genes, Rho GTPase activating protein 15 (<i>ARHGAP15</i>) and catenin alpha 2 (<i>CTNNA2</i>) have previously been linked to physiological traits associated with tropical adaptation in various cattle breeds. Interestingly, these two genes also showed signs of positive selection, indicating their potential role in conferring tolerance to trypanosomiasis, a prevalent tropical disease.Conclusion: Our findings provide valuable insights into the genetic basis of MY and FY in the Thai multibreed dairy cattle population, shedding light on the underlying mechanisms of tropical adaptation. The identified genes represent promising targets for future breeding strategies aimed at improving milk and fat production while ensuring resilience to tropical challenges. This study significantly contributes to our understanding of the genetic factors influencing milk production and adaptability in dairy cattle, facilitating the development of sustainable genetic selection strategies and breeding programs in tropical environments.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Genome-wide Association Analysismentioning

confidence: 99%

Genetic factors influencing milk and fat yields in tropically adapted dairy cattle: insights from quantitative trait loci analysis and gene associations

Laodim,

Koonawootrittriron,

Elzo

et al. 2024

Anim Biosci

View full text Add to dashboard Cite

show abstract

“…It is understandable that different viruses have direct implications on the function of the innate and adaptive immune systems (4)(5)(6). Hereupon, several studies have investigated the effects of BLV infection on lymphocyte subpopulations (2,4,5,7,8), functions of neutrophils (4,6,9), mammary epithelial cells (10)(11)(12), and monocytes (13). However, to the best of our knowledge, the effects of BLV infection on the function of milk macrophages and their viability are only speculative.…”

Section: Introductionmentioning

confidence: 99%

Milk Macrophage Function in Bovine Leukemia Virus-Infected Dairy Cows

et al. 2021

View full text Add to dashboard Cite

The implications of bovine leukemia virus (BLV) on innate and adaptive immune responses have been widely investigated; however, the effects of BLV on mammary gland immunity require further investigation. The present study investigated the viability, phagocytic capacity, and intracellular production of reactive oxygen and nitrogen species (RONS) by macrophages in milk samples from dairy cows naturally infected with BLV with or without persistent lymphocytosis (PL). No effect of BLV infection in the overall number of macrophages per milliliter and in the percentage of viable macrophages among overall milk viable cells was found. Furthermore, BLV-infected dairy cows had a higher frequency of viable milk macrophages, while healthy animals had a tendency toward a higher percentage of apoptotic milk macrophages. The percentage of milk macrophages that phagocytosed Staphylococcus aureus in seronegative animals was higher than that in BLV-infected dairy cows. No effect of BLV infection on the intracellular RONS production and the intensity of phagocytosis by milk macrophages was observed. Thus, this study provides new insights into the implications of BLV infections in the bovine mammary gland.

show abstract

Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches

Morales-Ubaldo

Rivero-Pérez

Valladares-Carranza

et al. 2023

Veterinary and Animal Science

View full text Add to dashboard Cite

Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile

Cited by 6 publications

References 38 publications

Genetic factors influencing milk and fat yields in tropically adapted dairy cattle: insights from quantitative trait loci analysis and gene associations

Genetic factors influencing milk and fat yields in tropically adapted dairy cattle: insights from quantitative trait loci analysis and gene associations

Milk Macrophage Function in Bovine Leukemia Virus-Infected Dairy Cows

Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches

Contact Info

Product

Resources

About