Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches

Morales-Ubaldo, Ana Lizet; Rivero-Pérez, Nallely; Valladares-Carranza, Benjamín; Delgadillo-Ruiz, Lucía; Zaragoza-Bastida, Adrián

doi:10.1016/j.vas.2023.100306

Cited by 18 publications

(17 citation statements)

References 185 publications

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“…Therefore, further elucidation of the pathogenesis of mastitis is imperative for accurate diagnosis and effective disease control. Numerous studies have acknowledged the detrimental impact of mastitis on women's health and mammalian populations, prompting exploration into alternative treatments such as dietary fiber intake, geraniol, and probiotic interventions 5–8 . However, a comprehensive understanding of the risk factors, pathophysiology, and optimal treatment methods for mastitis remains incomplete; thus, it is necessary to employ multi‐omics approaches to gain profound insights into the nature of this condition 3,9 …”

Section: Introductionmentioning

confidence: 99%

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Chen,

Hu,

Ren

et al. 2024

The FASEB Journal

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Mastitis is a disease characterized by congestion, swelling, and inflammation of the mammary gland and usually caused by infection with pathogenic microorganisms. Furthermore, the development of mastitis is closely linked to the exogenous pathway of the gastrointestinal tract. However, the regulatory mechanisms governing the gut‐metabolism‐mammary axis remain incompletely understood. The present study revealed alterations in the gut microbiota of mastitis rats characterized by an increased abundance of the Proteobacteria phylum. Plasma analysis revealed significantly higher levels of L‐isoleucine and cholic acid along with 7‐ketodeoxycholic acid. Mammary tissue showed elevated levels of arachidonic acid metabolites and norlithocholic acid. Proteomic analysis showed increased levels of IFIH1, Tnfaip8l2, IRGM, and IRF5 in mastitis rats, which suggests that mastitis triggers an inflammatory response and immune stress. Follistatin (Fst) and progesterone receptor (Pgr) were significantly downregulated, raising the risk of breast cancer. Extracellular matrix (ECM) receptors and focal adhesion signaling pathways were downregulated, while blood–milk barrier integrity was disrupted. Analysis of protein‐metabolic network regulation revealed that necroptosis, protein digestion and absorption, and arachidonic acid metabolism were the principal regulatory pathways involved in the development of mastitis. In short, the onset of mastitis leads to changes in the microbiota and alterations in the metabolic profiles of various biological samples, including colonic contents, plasma, and mammary tissue. Key manifestations include disturbances in bile acid metabolism, amino acid metabolism, and arachidonic acid metabolism. At the same time, the integrity of the blood–milk barrier is compromised while inflammation is promoted, thereby reducing cell adhesion in the mammary glands. These findings contribute to a more comprehensive understanding of the metabolic status of mastitis and provide new insights into its impact on the immune system.

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Section: Introductionmentioning

confidence: 99%

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Chen,

Hu,

Ren

et al. 2024

The FASEB Journal

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Section: Introductionmentioning

confidence: 99%

“…The aetiology of cattle mastitis can be infectious or non-infectious [ 1 , 7 ]. Cell-walled bacteria are the most commonly reported mastitis-causative agents, although a variety of other microorganisms, such as mycoplasmas, chlamydia, algae, fungi, and viruses, have also been associated with the disease [ 1 , 7 , 8 ]. According to the primary reservoir and mode of transmission, mastitis pathogens have been classified, although not strictly, as contagious or environmental [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Major contagious pathogens are Staphylococcus aureus , Streptococcus agalactiae , and Mycoplasma bovis , while coagulase-negative staphylococci (CoNS) and Corynebacterium bovis are considered minor contagious pathogens. Among numerous environmental pathogens, Escherichia coli and Streptococcus uberis are the most frequently isolated from mastitis cases [ 3 , 7 ]. A recent global study on bacterial pathogens of bovine mastitis demonstrated that S. aureus, followed by CoNS, E. coli , S. agalactiae , and S. uberis , are the major causative agents [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of yeast mastitis has increased in recent years, and the frequent isolation of Candida spp. or outbreaks of Candida mastitis has been reported in several countries [ 7 , 11 , 12 ]. For algae of the genus Prototheca , it is unclear whether they are contagious or environmental pathogens [ 9 ]; nevertheless, an increasing number of mastitis cases has been observed in recent decades [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Pathogens Associated with Bovine Mastitis: The Experience of Bosnia and Herzegovina

Rifatbegović,

Nicholas,

Mutevelić

et al. 2024

Veterinary Sciences

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To obtain improved insights into the complex microbial aetiology of bovine mastitis, this study investigated the pathogens involved in cattle mastitis in Bosnia and Herzegovina. A total of 179 milk samples from cows with clinical mastitis (CM) and subclinical mastitis (SCM), as well as eight bulk tank milk (BTM) samples from 48 dairy farms, were analysed by standard bacteriological and mycological methods. Mycoplasma detection and identification were performed using culture techniques and real-time polymerase chain reaction (PCR). A total of 88 (49.2%) mastitis samples were positive for known mastitis pathogens at 32 of 47 farms (68.1%). Mycoplasma bovis was a predominant pathogen (25/187; 13.4%) in the majority of herds (14/48; 29.2%) and accounted for 48.9% of positive CM samples. Escherichia coli was the second most dominant CM pathogen (34%), followed by Streptococcus agalactiae (10.6%), whereas Staphylococcus aureus and coagulase-negative staphylococci were the most common in SCM samples (17.1%). Other mastitis pathogens included Candida spp. and Prototheca zopfii. Two BTM samples were positive for M. bovis only, and one was positive for a mixed culture of S. aureus and Streptococcus uberis. The finding of various causative agents of bovine mastitis, with M. bovis emerging as the main pathogen, emphasizes the significance of comprehensive testing that includes not only common mastitis pathogens but also mycoplasmas, fungi, and algae.

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Revealing microbial diversity in buffalo milk with high somatic cell counts: implications for mastitis diagnosis and treatment

Jiang,

Xu,

et al. 2024

Vet Res Commun

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Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches

Cited by 18 publications

References 185 publications

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Pathogens Associated with Bovine Mastitis: The Experience of Bosnia and Herzegovina

Revealing microbial diversity in buffalo milk with high somatic cell counts: implications for mastitis diagnosis and treatment

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