Effect of body temperature and hypoxia on the ventilatory CO2 response in man

Comparative Control of Respiration

“…A similar sort of displacement of the CO 2 response line without a change in slope is reported for awake humans in hyperthermia (Vejby-Christensen and Petersen, 1973). On the other hand, Cunningham and O'Riordan (1957) reported a near doubling of the slope of the CO 2 response curve, with a 1.1e2.9 C increase in body temperature in humans.…”

Ventilatory changes in heat-stressed humans with spinal-cord injury

“…Data were averaged within 1-min epochs and across subjects within each group body temperature range typically encountered by most people with a spinal-cord injury, and similar to temperatures obtained in human panting studies. [18][19][20][21] It is therefore reasonable to assume that a substantial, thermally-induced physiological adaptation, if present, should have been revealed within the current project.…”

A Respiratory Drive in Addition to the Increase in Co2 Production at Raised Body Temperature in Rats

“…This combination must be made in conjunction with any direct measure of minute ventilation at raised temperature because, without it, it is impossible to separate the effects of the increase in COµ production from other temperature-related drives. Indeed failure to consider this combination in conjunction may contribute to the difficulty in providing a coherent explanation of what happens to the linear relationship between minute ventilation and Pa,COµ at raised temperatures (Cunningham & O'Riordan, 1957;Euler et al 1970;Vejby-Christensen & Petersen, 1973;Widdicombe & Winning, 1974;Natalino et al 1977;Olievier et al 1982;Cooper & Veale, 1986;Baker et al 1986). We estimated minute ventilation from integrated EMG activity of the diaphragm muscle in 13 rats, because having to use mechanical ventilation to lower Pa,COµ made it impossible also to measure ventilation more directly.…”