Comparative Control of Respiration

Hazari, Mehdi S.; Farraj, Aimen K.

doi:10.1016/b978-0-12-404577-4.00015-1

Cited by 4 publications

(2 citation statements)

References 301 publications

(308 reference statements)

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“…Most studies on homeostatic control of breathing have been done in rodent models, in which the experiments are mostly performed during the day, rodent's normal inactive period. Since, in general, rodents have relatively reduced chemosensitivities compared with primates (Hazari and Farraj 2015), the use of non-human primates (NHPs) has been proposed to fill the gap and translate rodent breathing data to humans (Sheikhbahaei 2020). The common marmoset (Callithrix jacchus) is a New World nonhuman primate (NHP) with a small body size (250 -600 g) similar to that of a rat.…”

Section: Introductionmentioning

confidence: 99%

An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

Bishop

Weinhold

Turk

et al. 2022

eLife

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The respiratory system maintains homeostatic levels of oxygen (O2) and carbon dioxide (CO2) in the body through rapid and efficient regulation of breathing frequency and depth (tidal volume). The commonly used methods of analysing breathing data in behaving experimental animals are usually subjective, laborious, and time-consuming. To overcome these hurdles, we optimized an analysis toolkit for the unsupervised study of respiratory activities in animal subjects. Using this tool, we analyzed breathing behaviors of the common marmoset (Callithrix jacchus), a New World non-human primate model. Using Whole-body Plethysmography in room air as well as acute hypoxic (10% O2) and hypercapnic (6% CO2) conditions, we describe breathing behaviors in awake, freely behaving marmosets. Our data indicate that marmosets' exposure to acute hypoxia decreased metabolic rate and increased sigh rate. However, the hypoxic condition did not augment ventilation. Hypercapnia, on the other hand, increased both the frequency and depth (i.e., tidal volume) of breathing.

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Section: Introductionmentioning

confidence: 99%

An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

Bishop

Weinhold

Turk

et al. 2022

eLife

View full text Add to dashboard Cite

show abstract

“…Studies on homeostatic control of breathing have been done mainly on rodent models, in which the experiments are mostly performed during the day i.e., rodent's normal inactive period. Since, in general, rodents have relatively reduced chemosensitivities compared with primates (Hazari and Farraj 2015), there is little assurance on if these results can effectively be extrapolated to humans. Therefore, use of non-human primates (NHPs) has been proposed to fill this gap and translate rodent data to humans (Sheikhbahaei 2020).…”

Section: Introductionmentioning

confidence: 99%

Breathing Behaviors in Common Marmoset (Callithrix jacchus)

Bishop

Turk

Adeck

et al. 2020

Preprint

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The respiratory system maintains homeostatic levels of oxygen (O2) and carbon dioxide (CO2) in the body through rapid and efficient regulation of frequency and dept (tidal volume) of breathing. The use of common marmoset (Callithrix jacchus), a New World non-human primate (NHP) model, in neuroscience is increasing, however, the data on their breathing is limited and their respiratory behaviors have yet to be characterized. Using Whole-body Plethysmography in room air as well as in hypoxic (low O2) and hypercapnic (high CO2) conditions, we sought to define breathing behaviors in an awake, freely behaving marmosets. Additionally, we instituted and optimized an analysis toolkit for unsupervised analysis of the respiratory activities in common marmoset. Our findings indicate that marmoset’s exposure to hypoxia decreased metabolic rate and increased sigh rate. However, the hypoxic condition did not augment the ventilatory response as reported in other animals. Hypercapnia, on the other hand, increased both the frequency and tidal volume as expected. In this study, we shed light on the breathing behaviors of common marmosets in a variety of O2 and CO2 conditions to further understand the breathing behaviors in NHPs.

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Anesthetic Management for Inflammatory or Infectious Respiratory Diseases

Lascola¹,

Clark‐Price²

2022

Equine Anesthesia and Co‐Existing Disease

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Comparative Control of Respiration

Cited by 4 publications

References 301 publications

An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

Breathing Behaviors in Common Marmoset (Callithrix jacchus)

Anesthetic Management for Inflammatory or Infectious Respiratory Diseases

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