Effect of blackberry juice (<i>Rubus fruticosus L.</i>) on anxiety-like behaviour in Wistar rats

Fernández-Demeneghi, Rafael; Rodríguez‐Landa, Juan Francisco; Guzmán-Gerónimo, Rosa-Isela; Acosta-Mesa, Héctor-Gabriel; Meza-Alvarado, Enrique; Vargas-Moreno, Isidro; Herrera‐Meza, Socorro

doi:10.1080/09637486.2019.1580680

Cited by 17 publications

(13 citation statements)

References 70 publications

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“…These ANTs inhibit metallo-proteinases 2 and 9, which are associated with the metastasis of cancerous cells, and cisplatin-induced renal pathophysiology [16,17,18,19]. The in vitro effect of ANTs on metabolic syndrome-related enzymes and anxiety has also been reported [20,21].…”

Section: Introductionmentioning

confidence: 99%

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

2019

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Anthocyanins (ANTs) are plant pigments that belong to a flavanol class of polyphenols and have diverse pharmacological properties. These compounds are primarily found in fruits and vegetables, with an average daily intake of 180 mgd−1 of these compounds in the developed world. ANTs are potent antioxidants that might regulate the free radical-mediated generation of amyloid peptides (Abeta-amyloids) in the brain, which causes Alzheimer’s disease (AD). This study presents a literature review of ANTs from different berries and their potential therapeutic value, with particular emphasis on neurodegenerative AD, which owing to oxidative stress. This review also highlights reactive oxygen species (ROS) generation through energy metabolism, nitrogen reactive species, the role of transition metals in generating ROS, and the radical-quenching mechanisms of natural antioxidants, including ANTs. The current status of the bioavailability, solubility, and structure activity relationship of ANTs is discussed herein.

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Section: Introductionmentioning

confidence: 99%

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

2019

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“…This suggests that Aronia supplement may increase not only lifespan, but healthspan also. However, in several other works, berry supplements had no effect on locomotor activity in rats (Eftimov and Valcheva-Kuzmanova 2018; Fernández-Demeneghi et al 2019; Janšakova et al 2016; Valcheva-Kuzmanova et al 2014; Valcheva-Kuzmanova and Zhelyazkova-Savova 2009) (Pomatto et al 2017). So the question has been raised, what exactly is the mechanism of influence on locomotor activity by berries?…”

Section: Resultsmentioning

confidence: 87%

Geroprotective effects of Aronia melanocarpa fruit extract on Drosophila melanogaster

Zemskaya

Shaposhnikov

et al. 2021

Preprint

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Aging and its consequences is one of the main problems of humanity. Phytochemicals such as polyphenols, flavonoids, anthocyanins have great potential as geroprotectors. Plants including Aronia used as dietary supplements are an excellent source of these compounds. We have studied the effects of the ethanol extract from Aronia fruits on Drosophila melanogaster lifespan, locomotor activity, stress resistance (oxidative stress, heat shock and starvation). And also, in order to reveal the influence of Aronia extract applied to different life cycles of Drosophila melanogaster, we selected different dietary schemes for imago: throughout life, during the first two weeks (1 - 2) and during average age (4 - 6 weeks). It was revealed that the ethanol extract of chokeberry increases the median life expectancy in males and females by 5% when Drosophila melanogaster is added to the diet for 4 - 6 weeks of life. This suggests that intervention even in old age is sufficient to increase lifespan. In addition, no harmful effects of ABE on locomotor activity were found as an indicator of fly health. We showed that Aronia extract increased stress resistance to hyperthermia and oxidative stress. At the same time, Aronia extract did not significantly affect the resistance of flies to starvation. ABE supplementation has increased the expression of heat shock proteins (Hsp27, Hsp68, Hsp83), oxidative stress resistance genes (Keap1, NRF, Sod1), some circadian clock genes (Clk, per), and gene of longevity Sirt1.

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“…Our working group [4] recently reported the anxiolytic effect from blackberry juice (doses intermediate: 5.83 mg/kg anthocyanins, 27.10 mg/kg polyphenols) on EPM in male Wistar rats, and the design was accompanied by the forced swim test (6 min). A decrease in the anxiety index was observed, without alterations in locomotor activity.…”

Section: Anxietymentioning

confidence: 99%

“…These compounds could be a supplementation alternative because they are able to cross the blood-brain barrier and accumulate in various structures [2,3] related to learning, memory, cognition process, and modification of behavior. In addition, their anti-neurodegenerative properties have been observed in diseases such as anxiety associated with stressful events [4] and reduction of depression, AD, and PD symptoms. Additionally, an association has been observed between the consumption of berries and increase in dendritic spine density in some brain structures and hippocampal neurogenesis [5].…”

Section: Introductionmentioning

confidence: 99%

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

Fernández-Demeneghi¹,

Isidro²,

Acosta-Mesa³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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This chapter is based in the compilation and analysis of different in vitro, preclinical, and clinical studies, which explored the potential beneficial bioactivity of supplementation with berries on some alterations in the central nervous system (CNS). The last section of the chapter describes the possible mechanisms of action of polyphenols, anthocyanins, and other compounds present in berries as well as their relationship with anxiety, depression, and Alzheimer's (AD) and Parkinson's diseases (PD) and their implication in the prevention of cognitive decline and senescence motor functions. Electronic databases as Springer, PubMed, Scopus, and Elsevier were used. Papers were selected by topic specially those related with berries, year of publication, and authors. The present chapter evidenced the potential health effect as neuroprotector of different berries and their bioactive compounds mainly flavonoids, polyphenols, and anthocyanins, on diseases such as anxiety, depression, and Alzheimer's and Parkinson's diseases. In conclusion, for human nutrition berry fruit supplementation might be an excellent source of antioxidant and alternative for prevention and reduction of symptoms in diseases such as anxiety, depression, Alzheimer's, and Parkinson's.

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Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats

Cited by 17 publications

References 70 publications

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

Geroprotective effects of Aronia melanocarpa fruit extract on Drosophila melanogaster

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

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